PI3K Akt pathway
The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism
... caspase-3, AKT and ERK1/2 and of their respective phosphorylated forms are ...by PI3K/AKT and HDAC in mutant KRAS lung adenocarcinoma ...Ras/Raf/MAPK pathway activation by mutant ...active ...
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UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway
... signaling pathway is an essential signaling pathway regulating cell survival and growth, proliferation, metabolism and genomic stability in eukaryotes cells [4, ...The PI3K/Akt pathway ...
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Low-Molecular-Weight Fucoidan Induces Endothelial Cell Migration via the PI3K/AKT Pathway and Modulates the Transcription of Genes Involved in Angiogenesis
... the PI3K/AKT pathway, which plays a crucial role in angiogenesis and ...were PI3K/AKT-dependent and that LMWF modulated the expression of genes involved at different levels of the ...
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Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
... IGF-1/insulin/FOXO pathway is implicated in improved healthspan, we then sought to determine whether CR modifies this pathway in human skeletal ...FOXO pathway were altered by CR. The PI3K and ...
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Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: Its potential use in the treatment of bladder cancers.
... the PI3K/AKT/mTOR pathwaywhich explains why PTEN negative tumors showed better responses to mTOR inhibitors, a rationale that have been used to test these derivatives in bladder cancers (Neshat, et ...with ...
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Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway
... the PI3K/Akt signaling pathway is involved in multiple cellular functions, including cell proliferation, apoptosis and inva- sion [21-23] ...the PI3K/Akt pathway is usually ...
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Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway.
... with our “one-two punch” strategy, in which, after transcription initia- tion, RNA elongation and protein translation should follow. In this light it is not surprising that TCR stimulation, which can trig- ger ...
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Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways
... to PI3K/AKT activation. FLX induces PI3K/AKT activa- ...activates PI3K/AKT 26 . So we hypothesized the implication of the PI3K/AKT ...of AKT, the downstream ...
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The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents.
... cells, Akt regulates the activity of the ankyrin-repeat domain–containing protein Kank, a central pro- tein involved in RhoA-dependent formation of actin stress fibers and cell migration ...that Akt ...
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Constitutive AKT activation in follicular lymphoma.
... the PI3K/AKT signaling pathway in MCL occurs most frequently by loss of PTEN expression and/or PIK3CA gene amplification, whereas the PIK3CA gene was found unmutated ...frequent AKT activating ...
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Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells
... of PI3K, stimulating the kinase activity (Chen et ...the PI3K pathway in CRC cells (Qi et ...the PI3K/AKT pathway activation, downregulation of p21, likely medi- ated by the ...
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Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies
... mTORC1 pathway and consequently stim- ulate MPS ...mTORC1 pathway in the skeletal ...mTORC1 pathway, they did not observe any effect of CIT (in combination with whey protein) between the two groups ...
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Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.
... both Akt and PI3K, suggesting a critical role for Nef as an adaptor protein in the PI3K/Akt pathway ...and PI3K has been shown 10 ...with Akt in PBLs treated with rNef ...
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Role of akt activation in PARP inhibitor resistance in cancer
... cytoprotective PI3K-Akt pathway is activated by PARP1 inhibition, and via multiple mechanisms, its activation induce apoptosis resistance and mitochondrial protection that limit cytostatic efficacy ...
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Akt signaling pathway: a target for radiosensitizing human malignant glioma
... that Akt intercept node could be a more relevant therapeutic target than STAT3 for radiosensitizing human malignant ...The PI3K/Akt pathway could be activated by numerous cytokines or growth ...
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The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCd-dependent inhibition of the AKT pathway
... the PI3K/ AKT pathway for their survival (Groszer et al, 2006; Yan et al, ...in AKT phosphorylation was observed in NSCs following prazosin ...
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JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways
... the PI3K-Akt signaling pathway has been suggested to be a critical regulator mediating resistance to MAPK inhibitors [26, ...the PI3K-Akt pathway as the putative target of JTC- ...
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Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila
... Ras/MAPK pathway in basal extrusion has only been described through the use of Ras V12 as an oncogenic hit, and role of PI3K/AKT/mTOR pathway has never been ...
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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
... of PI3K/mTOR inhibit osteosarcoma ...the PI3K/mTOR pathway were ...phosphorylated AKT (Ser473), AKT, phosphorylated S6 (Ser235/236), S6, PARP, and GAPDH (loading ...
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Activation anormale de la tyrosine kinase Lyn et de la voie PI3K/Akt dans les Leucémies Aiguës Myéloïdes (LAM) et ciblage pharmacologique
... of Akt may also contribute to the regulation of Thr308 ...of Akt. Indeed, the engagement of the Akt PH domain on the membrane by binding D3-polyphosphoinositides relieves autoinhibition of the active ...
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