Lung carcinoma
The sVEGFR1-i13 splice variant regulates a β1 integrin/VEGFR autocrine loop involved in the progression and the response to anti-angiogenic therapies of squamous cell lung carcinoma
... cell lung carcinoma patients are not eligible for bevacizumab treatment because it often leads to fatal haemorra- gies, which are not observed in lung ADC patients treated with the same ...
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Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma: E2F1 expression in human lung tumours
... human lung tumours E2F1 protein expression was studied on a panel of 58 lung tumour tissue samples by western-blotting using two monoclonal antibodies (Table 1, Figure ...normal lung tissues studied ...
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Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice
... 18 We next investigated if these in vitro antiangiogenic effects could be translated in vivo using Lewis lung carcinoma bearing mice. Fisetin was found to cause significant tumour growth inhibition when ...
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Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice.
... We next investigated if these in vitro antiangiogenic effects could be translated in vivo using Lewis lung carcinoma bearing mice. Fisetin was found to cause significant tumour growth inhibition when used ...
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A VEGF-A/SOX2/SRSF2 network controls VEGFR1 pre-mRNA alternative splicing in lung carcinoma cells
... mous lung carcinoma cells for 24 hours with various recombinant splice variants of VEGF-A, namely rhVEGF 121 , rhVEGF 165 and rhVEGF 189 ...in lung tumor ...Cell Lung Carcinoma (NSCLC) ...
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Abnormal Expression of the Pre-mRNA Splicing Regulators SRSF1, SRSF2, SRPK1 and SRPK2 in Non Small Cell Lung Carcinoma
... human lung carcinoma cell ...of lung adenocarcinoma (ADC) as well as in 68% and 91% of squamous cell lung carcinoma (SCC), respectively, compared to normal lung epithelial ...
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Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma
... human lung tumours E2F1 protein expression was studied on a panel of 58 lung tumour tissue samples by western-blotting using two monoclonal antibodies (Table 1, Figure ...normal lung tissues studied ...
24
Characterisation of gut, lung, and upper airways microbiota in patients with non-small cell lung carcinoma Study protocol for case-control observational trial Study Protocol Clinical Trial
... change in the gut and, to a lesser extent, the airway microbiota. [6] The study also reported an increase in blood levels of circulating short-chain fatty acids (SCFAs), one of the major products of bacterial ...
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Combination of tissue and liquid biopsy molecular profiling to detect transformation to small cell lung carcinoma during osimertinib treatment
... LC3 patient. This 77-year-old man, former smoker, with a T2N3M0 NSCLC harboring the EGFR L858R mutation, and p63-negative/TTF- positive by immunohistochemistry (diagnosis made in an external center) (Figure 1), received ...
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Nrf2-heme oxygenase-1 axis in mucoepidermoid carcinoma of the lung: Antitumoral effects associated with down-regulation of matrix metalloproteinases
... In lung cancers, the neoplasms causing the largest number of cancer-related deaths worldwide, Nrf2 gain-of-function and/or Keap1 loss-of-function mutations often occur [6] ...of lung tumors [7 , 8] ...
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Comprehensive molecular profiling of lung adenocarcinoma
... resequencing at a rate of 99% and 100%, respectively (Supplementary Fig. 3a, Supplementary Table 5). Tumour purity was not associated with the presence of false negatives identified in the validation data (P =0.31; ...
22
IGF2 promotes growth of adrenocortical carcinoma cells, but its overexpression does not modify phenotypic and molecular features of adrenocortical carcinoma.
... Supporting Information Figure S1 Cellular models of IGF2 knock-down in adrenal carcinoma. A: Transient extinction of IGF2 expres- sion by siRNA in H295R cells. Cells were transfected twice at day 1 and 2 after ...
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HLA-E(⁎)01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence.
... Pulmonary function tests (PFTs) were routinely con- ducted at our center on a monthly basis for the first 12 postoperative months, at 2-month intervals in the second year, and at 3-month intervals thereafter. In ...
10
IGF2 Promotes Growth of Adrenocortical Carcinoma Cells, but Its Overexpression Does Not Modify Phenotypic and Molecular Features of Adrenocortical Carcinoma
... Finally, we explored the molecular mechanism, which may explain differences in IGF2 expression amongst ACC. The IGF2 gene lies on an imprinted region of chromosome 11p15, which is a region with a complex epigenetic ...
14
Compressive stress enhances coordinated migration of mammary carcinoma cells
... mammary carcinoma cell lines MCF-7, MDA-MB-231 were obtained from American Type Culture Collection (ATCC) while the murine 4T1 and 67NR were kindly provided by ...renal carcinoma cell lines SN12C and SN12L1 ...
247
The heterogeneity of plasma miRNA profiles in hepatocellular carcinoma patients and the exploration of diagnostic circulating miRNAs for hepatocellular carcinoma
... Liver cancer is the fifth most common cancer worldwide, but it was the second most fre- quent cause of cancer-related death worldwide for men in 2013 [ 15 ]. Hepatocellular carcinoma (HCC) is the major type of ...
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Comprehensive molecular characterization of clear cell renal cell carcinoma
... cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for example, ...
8
Computational Modelling of Metastasis Development in Renal Cell Carcinoma
... In this context, mathematical models provide powerful tools to potentiate data analysis, infer hidden information, test biological hypotheses against the empirical data and simulate a range of conditions that may be ...
24
Biomimetic Culture Reactor for Whole-Lung Engineering
... The predominant commercially available apparatus designed to work with human lungs are ex vivo lung per- fusion (EVLP) systems, used in the pioneering clinical work of the Lund group 12–16 and the Toronto group. ...
14
The Role of Stroma in Breast Carcinoma Growth in Vivo
... 16. K. Henning, H. Kosmehl, A. Berndt, P. Rousselle, and D. Gabier Katenkamp (1995). Differential expression of laminin chains is benign and malignant lesions of the breast. Pathol. Res. Pract. 191:175. 17. A. ...
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