JAK/STAT pathway
Jak-Stat pathway induces Drosophila follicle elongation by a gradient of apical contractility
... A JAK-STAT gradient from the poles is the cue for early elongation Once the follicle is formed, polar cells are important for the differentiation of the surrounding ...the JAK-STAT ...
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Loss-of-Function Mutation in PTPN2 Causes Aberrant Activation of JAK Signaling Via STAT and Very Early Onset Intestinal Inflammation
... Keywords: Autoimmunity; Immune Regulation; PTPN2; VEO- IBD. G enome-wide association studies have linked non- coding single-nucleotide polymorphisms in the PTPN2 locus to several immuno-mediated diseases, including ...
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Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression
... of JAK/STAT signaling inhibition in Treg at the molecular level In order to determine whether inhibiting JAK/STAT signaling pathway in Treg might impact other genes than Foxp3 in the ...
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Estimation de la répétabilité et de la reproductibilité des mesures expérimentales. Utilisation des procédures VARCOMP et NESTED du logiciel SAS/STAT (version 6.12)
... Introduction Ce document a pour but de montrer comment estimer des variances de répétabilité et de reproductibilité des mesures expérimentales en se plaçant dans le contexte du modèle de l’analyse de la variance. Il a ...
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Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway
... Discussion The hexosamine biosynthetic pathway is involved in the post-translational addition of O-GlcNAc onto proteins that regulates gene transcription and cell signalling 4 . Remarkably, the HBP flux increases ...
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Stress hormone secretion and gut signal transducer (STAT) proteins after burn injury in rats.
... intracellular pathway leading to a dimerization of phosphorylated STAT5, entry of the dimer in the nucleus, and binding of the dimer to GAS (gamma activation sites) response elements triggering specific gene ...
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A journey through the exocytic pathway
... Journal of Cell Science 115, 1779-1780 (2002) © The Company of Biologists Ltd The poster is composed of three panels, which represent the three major protein families required for the journey of cargo through the ...
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Programme d’amélioration de la qualité de la surveillance de la thérapie anticoagulante orale en fibrillation auriculaire en pharmacie : une étude pilote intégrée au Réseau STAT
... 1. Introduction Depuis quelques années, il y a eu une augmentation de la création de réseaux étant définis comme des groupes ou des systèmes interconnectés ayant un but commun. 1 Les réseaux de recherche basée sur la ...
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On the Diagnostic of Road Pathway Visibility
... francois.goulette@mines-paristech.fr Abstract Sight distance along the highway plays a significant role in road safety and in particular, has a clear impact on the choice of speed limits. Visibility distance is thus of ...
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Tolérance et efficacité des inhibiteurs de JAK dans la polyarthrite rhumatoïde en comparaison aux DMARDs biologiques : une étude monocentrique
... of STAT proteins, which then migrate into the nucleus, causing the transcription of their targeted genes responsible for the production of pro- inflammatory elements involved in RA ...this pathway, led to ...
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Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway
... biosynthetic pathway, and that augmentation of O-GlcNAcylated proteins occurs in the context of glucose deprivation and during amino acid shortage as well ...
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Bladder cancer and the Notch pathway
... Notch pathway Pablo ...Notch pathway in cancer has been known since it was found hyperactivated in acute T-cell lymphoblastic leukemias (T-ALL) one decade ...Notch pathway and cancer has been ...
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Les inhibiteurs de la voie JAK : nouvelle classe pharmacologique dans la prise en charge de la polyarthrite rhumatoïde
... de JAK par une action de type ...unités JAK. Il y a alors une phosphorylation des JAK qui permet leur ...de STAT au niveau de la tyrosine phosphorylée. Les molécules JAK vont alors ...
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Régulation moléculaire et pharmacologique de la voie JAK/STAT3 : implication dans l'inflammation et dans l'angiogenèse tumorale
... Mis à part ces facteurs intrinsèques à l ' activation de STAT3, plusieurs autres facteurs extrinsèques environnementaux sont aussi connus pour induire les diver s types[r] ...
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JAK/STAT : de l’inflammation à la mémoire
... Notre étude s’est limitée à la phase d’in- duction de la NMDAR-LTD. Nous ne pou- vons exclure que ce transfert de STAT3 dans le noyau, que nous avons observé, n’a pas un rôle dans la maintenance de la LTD. En effet STAT3 ...
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The LKB1 complex-AMPK pathway: the tree that hides the forest.: The LKB1 complex-AMPK pathway
... AMPK/mTOR pathway connecting cellular metabolism, cell growth and tumorigenesis has been extensively studied probably to the detriment of other functions of equal ...
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The hedgehog pathway and ocular developmental anomalies
... from the very first stages of specification of the neural epi- thelium, to determining the eye fields, to the maintenance of healthy functional ocular tissues in the adult organism. Over the last 25 years, the number of ...
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NOTCH pathway inactivation promotes bladder cancer progression
... Previous studies on mouse and human keratinocytes have proposed a mechanism for the tumor-suppressive activity of the NOTCH pathway in skin that relies in part on its role in terminal differentiation (42, 43). ...
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Electric vehicle as a pathway for deep decarbonization
... General conclusions and future perspectives The main goal of this PhD thesis is to obtain the maximum penetration of electric vehicles as a pa- thway for deep decarbonization pathway project. In order to reach ...
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Amazonian Triatomine Biodiversity and the Transmission of Chagas Disease in French Guiana: In Medio Stat Sanitas
... As this condition typically hold for intrusive vectors such as those present in French Guyana, we focused on the FOI to assess how the observed variations in vector diversity, abundance,[r] ...
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