ERK pathway
Role of the ERK pathway in psychostimulant-induced locomotor sensitization.
... intense ERK activation in a subset of medium size spiny neurons in the NAcc as well as in the dorsal striatum ...the ERK pathway is the main factor responsible for the induction of Fos family genes ...
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A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway
... Methods: The primary objective is to determine the objective response rate of trametinib as a single agent for treatment of progressing/refractory tumors with MAPK/ERK pathway activation. The TRAM-01 study ...
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HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway
... MAPK/ERK pathway inhibitor ...MAPK/ERK pathway inhibition reduced the synergistic effects of HGF upon migration induced by both LM-111 and FN ...
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Inhibition de l'angiogenèse tumorale : criblage d'une chimiothèque et caractérisation d'un nouveau composé agissant sur la voie de signalisation Ras-ERK
... In this work, we screened the recently built-up library of the Department of Molecular Chemistry from the University of Grenoble (France) for compounds that can efficiently inter- fere with the angiogenic process. Such ...
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en fr Fucoidan Stimulates Monocyte Migration via ERK/p38 Signaling Pathways and MMP9 Secretion Le fucoidane stimule la migration des monocytes via la voie de signalisation ERK/P38 et la sécrétion de MMP9
... of ERK 1/2 and p38, two signaling pathways involved in monocyte migration and transmigration ...the ERK pathway is involved in monocyte adhesion, while the p38 pathway would be involved in ...
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Rôle des voies de signalisation de deux protéines kinases, Erk et Akt, dans l'effet anti-œdémateux de l'érythropoïétine
... of ERK phosphorylation, although it increased Akt phosphorylation at ...the ERK-1/-2 inhibitor, U0126, or the Akt inhibitor, LY294002, before injury showed that ERK was required for brain edema ...
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Fonctions antitumorales de la voie ERK/MAPK et développement rationnel de nouvelles stratégies thérapeutiques
... down-regulate ERK levels/activity to avoid senescence and other anti-proliferative consequences of high ERK ...high ERK levels had better survival and responded better to treatment (482), suggesting ...
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Bridging the Gap: A Theoretical Model of Mechanotransduction Through ERK Signalling
... Introduction Integrins play a crucial role in the mechanotransduction of anchorage- dependent cells. They transmit the mechanical signals and initiate signalling pathways which ultimately alters transcription in the ...
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TIMP-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells
... MEK/ERK pathway and cell migration - We used HT-MT1 cells, which overexpressed MT1-MMP, to recapitulate the effects we observed in siRNAscr cells, which produce MT1-MMP ...
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Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
... Tyrosine kinase A (TrkA) is a membrane receptor which, upon ligand binding, activates several pathways including MAPK/ERK signaling, implicated in a spectrum of human pathologies; thus, TrkA is an emerging ...
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Anomalies moléculaires de la voie MAPK et cancer papillaire de la thyroïde : étude de deux phosphatases spécifiques de ERK, DUSP5 et DUSP6
... 3. L’oncogène B-RAF. B-RAF fait partie de la cascade de signalisation RAF-MEK-ERK qui régule la croissance cellulaire, la prolifération et la différentiation en réponse à une stimulation par des facteurs de ...
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The LKB1 complex-AMPK pathway: the tree that hides the forest.: The LKB1 complex-AMPK pathway
... AMPK/mTOR pathway connecting cellular metabolism, cell growth and tumorigenesis has been extensively studied probably to the detriment of other functions of equal ...
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Signaling pathway switch in breast cancer.
... signaling pathway plays a role in the early G1 subphase, where the cell may be induced into quiescence, senescence or committed to differentiation, depending on the presence of external factors ...
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Régulation de l'expression génique et de la sécrétion des cytokines chez le neutrophile humain : implication de la voie des MAPK MEK/ERK et son découplage
... Hydrogen peroxide induces murine macrophage chemokines gene transcription via extracellular signal-regulated kinase- and cyclic adenosine 5' -mono phosphate ( cAMP)-dependant pathways:[r] ...
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Bladder cancer and the Notch pathway
... signaling pathway is not generally considered a potent activator of the MAPK ...Notch pathway transcriptionally activates several members of the dual- specificity phosphatases (DUSPs), including DUSP1, by ...
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A journey through the exocytic pathway
... GTPases are likely to play critical role in the ordered assembly of these tethering- fusion complexes. Therefore, the sequential assembly of vesicle coats that direct cargo selection (left panel) and recruitment of the ...
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Inhibition de l’angiogenèse tumorale : criblage d’une chimiothèque et caractérisation d’un nouveau composé agissant sur la voie de signalisation Ras-ERK
... Focal Adhesion Kinase (FAK) are affected downstream of Ras inhibition (25). More detailed studies will be required to elucidate these mechanisms. Intraperitoneal administration of COB223 to LLC/2 tumor- bearing mice ...
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Phospho-ERK and sex steroids in the mPOA: involvement in male mouse sexual behaviour
... behaviour, locomotor activity, olfactory preference and ERK phosphorylation in the mPOA of sexually 634. experienced males[r] ...
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On the Diagnostic of Road Pathway Visibility
... francois.goulette@mines-paristech.fr Abstract Sight distance along the highway plays a significant role in road safety and in particular, has a clear impact on the choice of speed limits. Visibility distance is thus of ...
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NOTCH pathway inactivation promotes bladder cancer progression
... NOTCH pathway accelerated bladder tumorigenesis and promoted the formation of squamous cell carcinomas, with areas of mesenchymal ...NOTCH pathway stabilizes the epithelial phenotype through its effector ...
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