Endothelin receptor
Iontophoresis of endothelin receptor antagonists in rats and men.
... 1 Clinical Pharmacology Unit, Inserm CIC03, Grenoble University Hospital, Grenoble, France, 2 Laboratoire HP2 - U1042, Inserm, Grenoble, France, 3 Joseph Fourier University, Grenoble, France, 4 Vascular Medicine ...
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Randomized Dose-Response Study of the New Dual Endothelin Receptor Antagonist Aprocitentan in Hypertension
... Summary Aprocitentan, a dual endothelin receptor antagonist, was evalu- ated in a dose-response study examining its effects on BP in 490 patients with mild-to-moderate hypertension. Changes in BP were ...
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Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism
... the endothelin receptor antagonist macitentan was added to test the hypothesis that the cardiac effects of sunitinib were, in part, mediated by the endothelin pathway (Figure ...
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Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma
... alterations in gene expression were not due to the therapeutic regimen used to treat the mice from which the brain-metastatic variants were derived (i.e. metronomic chemotherapeutic using the combination of vinblastine ...
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Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension
... secrete endothelin (ET-1) in vessels that lead to a potent and long-lasting vasoconstrictive effect in pulmonary arterial smooth muscle ...of endothelin receptor antagonists (ERA) used in the ...
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Therapeutic potential of endothelin receptor type A and bradykinin receptor B1 dual antagonism in osteoarthritis treatment
... Methods: Osteoarthritis was surgically induced in rats by transection of the right anterior cruciate ligament. Animals were subsequently treated with weekly intra- articular injections of specific peptide antagonists of ...
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Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca2+ in adult cardiac myocytes
... of endothelin receptors has been demonstrated in rat liver [56], rat cardiomyocytes [12], and mouse spiral ganglion neurons ...the endothelin receptor subtype on nuclear membranes in ventricular ...
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Source-receptor matrix calculation with a Source-receptor matrix calculation with a backward mode
... ship. The length of each square is 1 ¹ . The parameter shown is the s–r relationship [s], calculated with the mode represented by green squares in Figure 2. ward calculations modes for the s–r relationship in general. In ...
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Hyperfunction of Muscarinic Receptor Maintains Long-Term Memory in 5-HT4 Receptor Knock-Out Mice
... 4 Receptor Knock-Out Mice Luis Segu 1{ , Marie-Jose´ Lecomte 2 , Mathieu Wolff 1 , Julie Santamaria 2 , Rene´ Hen 3 , Aline Dumuis 4 , Sylvie Berrard 2 , Joe¨l Bockaert 4 , Marie-Christine Buhot 1 , Vale´rie ...
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Development of pure prolactin receptor antagonists
... Prolactin Receptor Antagonists* Received for publication, May 30, 2003, and in revised form, June 23, 2003 Published, JBC Papers in Press, June 24, 2003, DOI ...
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System modeling of receptor-induced apoptosis
... However, while cell fate is almost fully determined by cell state at treatment time when protein synthesis is blocked, it is only partially the case in normal treatment conditions, in which survival of a fraction of the ...
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Modified Receptor Internalization upon Co-expression of 5-HT1B Receptor and 5-HT2B Receptors.
... Quantitative internalization kinetics of the GFP-tagged receptors was assessed by measuring the fluorescence intensity disappearance at the membrane compared with the intensity increase in the cytoplasm of about ten ROI ...
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The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.: The Mineralocorticoid Receptor
... A brief history In the late 1960’s, evidence for the presence of specific receptors mediating corticosteroid action in the toad bladder was initially proposed by the group of Edelman [Porter and Edelman, 1964]. ...
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Progesterone receptor, obesity and prognosis in women diagnosed with estrogen receptor positive breast cancer
... its receptor can result in the repression of progesterone receptor (PR) gene transcription in ER+ cells through the phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway ...
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Impact of receptor clustering on ligand binding.
... homogeneous receptor spacing and receptor ...the receptor occupation in function of the dose decreased, but still reached the same saturation ...a receptor to another than fast diffusing ...
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A trilogy of glucocorticoid receptor actions
... glucocorticoid receptor actions Chek Kun Tan a and Walter Wahli a,b,c,1 Glucocorticoids (GCs) belong to a class of endoge- nous, stress-stimulated steroid hormones found in vertebrates ...GC receptor (GR), ...
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Hypoglycaemia revealing heterozygous insulin receptor mutations.
... insulin receptor mutations Vanessa Preumont 1 , Christine Feincoeur 1 , Olivier Lascols 2,3 ,CarineCourtillot 3,4 ,Philippe Touraine 3,4 , DominiqueMaiter 1 ,CorinneVigouroux 2,3 1 Department of Endocrinology and ...
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The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies
... the receptor as baits, in line with previous work that identified these domains as critical sites for the recruitment of GPCR interacting proteins and their coupling to G proteins, ...the receptor recruits ...
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Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications
... In a small randomized controlled pilot study in OSA patients (n=16) with mild untreated hypertension (clinical BD of 142/85 mmHg), we recently showed that a 4-‐week bosentan treatment resulted in a 3 mmHg greater ...
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Receptor-interacting protein 140 is a repressor of the androgen receptor activity.: AR repression by RIP140
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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