double strand breaks (DSBs)
en fr Role of chromatin remodeling enzymes in the repair of DNA double strand breaks and genetic instability Rôle des modifications de la chromatine dans la réparation des cassures double-brin de l'ADN et la stabilité génétique
... SUMMARY The human genome is constantly targeted by DNA damaging agents. These damages are many and varied, such as single and double strand breaks (DSBs). The DSB are highly toxic lesions whose ...
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Selective mitochondrial DNA degradation following double-strand breaks
... undergo double-strand breaks (DSBs), caused by defec- tive replication, or by various endogenous or exogenous sources, such as reactive oxygen species, chemotherapeutic agents or ionizing ...
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ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
... DNA double strand breaks (DSBs): non-homologous end-joining (NHEJ), that requires two adjacent DNA ends for ligation, and homologous recombination (HR), that resects one DNA strand for ...
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BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
... DNA double-strand breaks (DSBs) along the genome is instrumental to understanding genomic fragility, but current methods are limited in versatility, sensitivity or ...present Breaks Labeling ...
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AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells
... DNA double-strand breaks in colorectal cancer cells Nina Seiwert 1,6 , Carina Neitzel 1,6 , Svenja Stroh 1 , Teresa Frisan 2 , Marc Audebert 3 , Mahmoud Toulany 4,5 , Bernd Kaina 1 and Jörg Fahrer* ...
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Signaling of double strand breaks and deprotected telomeres in Arabidopsis
... sensing, double strand breaks, telomere, DNA repair DSBs REPAIR PATHWAYS IN ARABIDOPSIS THALIANA Double strand breaks (DSB) repair pathways are classed as either homologous ...
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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
... DNA double-strand breaks (DSBs) is ...single- strand breaks (SSBs) on opposing DNA strands: one SSB from the removal of transcription-blocking TOP1ccs by the TDP1 pathway and the other ...
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Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?
... Mireille Be´termier, 1 , * Vale´rie Borde, 2 , * and Jean-Pierre de Villartay 3 , * DNA double-strand breaks (DSBs) are the most toxic DNA lesions given their oncogenic poten- tial. Nevertheless, ...
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Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
... Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a putative RNA:DNA helicase involved in ...
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Physical interaction between the histone acetyl transferase Tip60 and the DNA double strand breaks sensor MRN complex
... Synopsis Chromatin modifications and chromatin modifying enzymes are believed to play a major role in the process of DNA repair. The Tip60 histone acetyl transferase is physically recruited to DNA double ...
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XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition
... ABSTRACT Unrepaired O 6 -methylguanine lesions induced by the alkylating chemotherapy agent temozolomide lead to replication-associated single-ended DNA double-strand breaks (seDSBs) that are ...
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C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.
... Received July 19, 2015; Revised February 26, 2016; Accepted February 29, 2016 ABSTRACT Non-homologous end joining is a ligation process re- pairing DNA double strand breaks in eukaryotes and many ...
23
en fr Signalization and repair of the DNA double-strand breaks of in the cerebral tumors: Modulation of the radiation response with the chemotherapy treatments. Signalisation et réparation des cassures double-brin de l'ADN dans les gliomes : Modulation de la réponse aux traitements chimio-radiothérapeutiques.
... DNA double-strand breaks of in the cerebral tumors: Modulation of the radiation response with the chemotherapy ...DNA double-strand breaks repair pathway depending on the MRE11 ...
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Ku counteracts mobilization of PARP1 and MRN inchromatin damaged with DNA double-strand breaks
... INTRODUCTION Double-strand break (DSB) is toxic DNA damage that, if improperly repaired, can lead to cell death or cancer fol- lowing genomic rearrangement ...
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Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
... DNA double strand breaks, recruiting and activating the catalytic sub-unit, DNA-PKcs ...DNA double-strand breaks by the NHEJ pathway ...DNA double strand ...
11
Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4
... Programmed formation of DNA double-strand breaks (DSBs) initiates the meiotic homologous recombination pathway. This pathway is essential for proper chromosome segregation at the first meiotic ...
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The Secret Life of Chromosome Loops upon DNA Double-Strand Break
... DNA Double Strand Break response and repair DNA Double Strand Breaks (DSBs) represent challenging lesions for cells, as they can lead to major genome rearrangement such as ...
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De novo telomere addition at chromosome breaks: Dangerous Liaisons
... DNA strand synthesized by the lagging strand replication machinery or accidental collapse of the replication ...DNA double strand breaks (DSBs) and may occasionally add telomeric re- ...
4
[Bacterial infections as seen from the eukaryotic genome: DNA double strand breaks, inflammation and cancer].
... (cassures double-brin, simple-brin, ...cassures double-brin de l’ADN se produisent dans un contexte d’inflammation chronique, un état où l’organisme est déjà ...cassures double-brin pourraient être ...
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Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation
... preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted Fe[r] ...
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