cyclic-nucleotide binding domain
A Novel Dimerization Interface of Cyclic Nucleotide Binding Domain, which is Disrupted in Presence of cAMP: Implications for CNG Channels Gating
... CNBD domain R307W mutant with hampered cAMP binding, PDB ID 3CO2 [8], and the other one is of Epac2, PDB IDs 1O7F [15] and 2BYV ...cAMP binding, and thus the CNBD monomerization upon binding ...
18
Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.
... yclic nucleotide-modulated ion channels play a crucial role in signal transduction and pacemaking in eukaryotes by coupling changes in the levels of the intracellular signalling molecules, cyclic AMP or ...
11
Ion channels: new tools to track cyclic nucleotide changes in living cells
... Hyperpolarization-activated, cyclic nucleotide-gated channels: a novel sensor to monitor cytosolic cAMP in living cells Hyperpolarization-activated, cyclic nucleotide-gated cation channels ...
21
The gating mechanism in cyclic nucleotide-gated ion channels
... the binding of CNs to the conformational changes in the transmembrane domain occurs following these key steps: i- the binding of CNs is followed by rearrangements in the C-linker with the A’ helices ...
16
Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum
... cGMP binding domain of the bovine PKG ...its binding site would be saturated. We therefore replaced the CNB-A binding site within the sensor with a copy of the structurally very similar CNB-B ...
49
en fr Cyclic nucleotide phosphodiesterases in heart and vessels: A therapeutic perspective Phosphodiestérases des nucléotides cycliques dans le coeur et les vaisseaux : une perspective thérapeutique
... two binding sites for the Ca 2+ -binding protein calmodulin in the N-domain, which are responsible for enzyme stimulation by Ca 2+ ...by cyclic nucleotides. In particular, for PDE2 and PDE5, ...
37
Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel
... Cap domain (residues 1-26) in hERG3-eag is mostly unresolved in our ...Cap domain, which contains a flexibly-linked, but stable amphipathic helix, is already known to affect channel activity ...heme ...
17
THE N-TERMINAL DOMAIN OF ANNEXIN 2 SERVES AS A SECONDARY BINDING SITE DURING MEMBRANE BRIDGING
... N-terminal domain in the free soluble form of the protein at acidic pH in the absence of calcium and the conformational and environment changes of this domain that may occur during membrane bridging, using ...
19
Mercury Trithiolate Binding (HgS3) to a de Novo Designed Cyclic Decapeptide with Three Preoriented Cysteine Side Chains
... Abstract. Mercury (II) is an unphysiological soft ion with high binding affinity for thiolate ligands. Its toxicity lies in the interactions with low molecular weight thiols including glutathione and ...
32
The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain.
... AMIN domain and the C-terminal catalytic ...amidase_3 domain clearly shows the obstruction of the active site by an α-helix confirming the observation made with the septal amidase AmiB from ...as ...
11
Dissociation of the Dimer of the Intrinsically Disordered Domain of RNase Y upon Antibody Binding
... non-catalytic domain of Bacillus subtilis RNase Y (BsRNaseY) that is predicted to be intrinsically ...this domain can be produced as a stand-alone protein called Nter-BsRNaseY that undergoes conformational ...
46
A rational engineering strategy for designing protein a-binding camelid single-domain antibodies
... SpA binding ( Fig 3 and Table 5 ...Ab:antigen binding affinities relative to various individual methods when applied to over 200 single-point antibody mutants of the SiPMAB database curated from the ...
19
Structural Insights into the Nucleotide-Binding Domains of the P1B-type ATPases HMA6 and HMA8 from Arabidopsis thaliana
... the nucleotide binding domain of HMA6 and HMA8, the former at the highest resolution, obtained for any P-type ATPase ...isolated domain to bind ATP and can be a way of regulating the ...
17
Human Dicer helicase domain recruits PKR and dsRNA binding proteins during viral infection
... Human Dicer helicase domain recruits PKR and dsRNA binding proteins during viral infection... Abstract 20.[r] ...
60
Cisplatin in yeast--repair of DNA adducts and binding of HMG domain proteins
... Cisplatin cytotoxicity assays performed on the excision repair deficient strains rad4 IXR1, rad14 IXR1, rad4 ixrl, and radl4.. ixrl ...[r] ...
343
Dissociation of the dimer of the intrinsically disordered domain of RNase Y upon antibody binding
... disordered domain (IDD) (Figure 1), a catalytic domain with KH (residues 210-280) (15) and HD motifs (residues 330- 430) (16) and a C-terminal region of unknown ...
46
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor.
... facilitates binding to sites of suboptimal ...DNA binding of LFY TERE is probably partially explained by its capacity to bind as a monomer and scatter over the numerous monomeric sites of the ...in ...
13
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
... P DZ domains are among the most common interaction modules in the human proteome, with B270 domains imbedded in 4150 proteins 1 . Their name is derived from the first three proteins in which these domains were found, ...
14
Oligomeric status and nucleotide binding properties of the plastid ATP/ADP transporter 1: toward a molecular understanding of the transport mechanism.
... ADP binding properties were determined, and Pi, a co-substrate of ADP, was confirmed to be essential for nucleotide steady-state ...transport. Nucleotide binding studies and analysis of NTT1 ...
11
PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice
... * mducdodo@ens-lyon.fr Abstract Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leuke- mia/lymphoma (ATLL), an aggressive malignant proliferation of activated CD4+ T lympho- cytes. ...
24