Antiretroviral drug
Solubility of a new antiretroviral drug (CRS 74) in aqueous ethanol mixtures
... Keywords: antiretroviral drug, solubility, UNIQUAC, aqueous ethanol mixture. INTRODUCTION This study concerns a new compound, (2S, 3S, 5S)-2, -5 bis- [N-[N-[[N- methyl- N-[(2- isopropyl- 4- thiazolyl) ...
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The Senegalese Antiretroviral Drug Access Initiative
... ■ In 1998, Senegal became the first country in sub-Saharan Africa to establish a public antiretroviral treatment programme, the Senegalese Antiretroviral Access Initiative (ISAARV). Introducing such a ...
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Liquid anti-solvent recrystallization to enhance dissolution of CRS 74, a new antiretroviral drug
... the drug dissolution rate, due to the increase of wetting properties attributable by specific interactions between the drug surface and the ...avoid drug adsorption onto stainless steel T- ...of ...
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Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4 + T cell recovery can harbor replication-competent HIV despite viral suppression
... Longitudinal CD4 + T-cell count and plasma viral load measurements around the date of sampling in patients with sustained controlled viremia below LOD and platelets positive for HIV an[r] ...
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Improvement of dissolution rate of a new antiretroviral drug using an anti-solvent crystallization technology
... A continuous and highly effective static mixing process for antisolvent precipitation of nanoparticles of poorly water-soluble drugs, International Journal of Pharmaceutics.. Controlled [r] ...
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Does short-term virologic failure translate to clinical events in antiretroviral-naïve patients initiating antiretroviral therapy in clinical practice?: VF & Clinical Events by ART Regimen
... IAS-USA drug resistance mutations and resistance to more antiretroviral drug classes when compared to patients initiating therapy with ritonavir-boosted PI containing regimens [ 45 ] ...of ...
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Access to antiretroviral drugs and AIDS management in Senegal
... to antiretroviral drugs in ...whom antiretroviral treatment was medically indicated had access to the programmes, for reasons relating both to AIDS itself (diagnostic errors, difficult access to screening, ...
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Optimization of Drug-Eluting Stents
... of drug distribution and its average concentration in the arterial wall [140, ...DES drug de- livery strategies, which are determined by the release kinetics (elution process) in the polymer coating and the ...
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Managing drug-drug interactions with new direct-acting antiviral agents in chronic hepatitis C.
... Drug Administration classification states that a drug is a powerful inhibitor (or inducer) of CYP if it increases (or decreases) substrate exposure by a factor of at least five ...
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Computer-Aided Drug Target Search
... Computer-Aided Drug Target Search ...of drug toxicity and side effect, and (3) analysis of protein-mediated pharmacokinetic properties of ...computer-aided drug target search method and its ...
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Analytics for financing drug development
... on methodology. ‡ includes both successful and failed trials. * confirmed with author to include NDA filing times. 2.3.3 Duration A similar body of work has been done to estimate clinical durations by stage of ...
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Drug Calculation : Do Calculators Make a Difference on Drug Calculations Outcomes for Nursing Students?
... the drug calculation which involves understanding the components of a prescription, drug label and medication sheet as well as being able to identify the information required to solve the drug ...
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Effect of drug loading and plasticizer on drug release from poly lactic acid film
... When the solubility of drug molecules in the polymer is very slow, the drug is uniformly dispersed throughout the polymer, exhibiting a release that is controlled by the diffusion ot the[r] ...
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Prevention of postnatal HIV infection: infant feeding and antiretroviral interventions
... peri-partum antiretroviral therapy reduces the risk of mother-to-child transmission of HIV around delivery [2], but the subsequent risk of postnatal HIV transmission results in a great number of paediatric HIV ...
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View of Antiretroviral therapy in the intensive care unit
... Abstract Antiretroviral drugs have dramatically improved the prognosis of human immunodeficiency virus (HIV) infection over the recent ...manage antiretroviral drugs besides the regular intensive care ...of ...
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Fixing Transnational Drug Policy Drug Prohibition in the Eyes of Comparative Law
... the drug control ...UN drug control treaties on national ...of drug policy research. Reciprocally, the study of drug prohibition from the perspective of comparative law can inform the ongoing ...
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Impact of antiretroviral treatment on height evolution of HIV infected children
... ART: Antiretroviral treatment; BIC: Bayesian information criterion; BSV: Between-subject variability; CDC: Centers for Disease Control and Prevention; HAZ: Height-for-age z-score; IQR: Interquartile range; LRT : ...
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Boceprevir (BOC) and Telaprevir (TPV) therapeutic drug monitoring in HCV and HIV-HCV infected patients treated with triple therapy Ribavirine/Peg-interferon/Boceprevir or Telaprevir: impact of the antiretroviral (ARV) treatment
... by drug interactions with some ARV. Hence, therapeutic drug monitoring is useful to manage these interactions and evaluate the risk-benefit balance of using non recom- mended ARV in coinfected patients with ...
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ERK2: a logical AND gate critical for drug-induced plasticity?: ERK2 and drug-induced plasticity
... receptors including mGluR5 (see Fig. 1). Thus, the ERK2 pathway operates as a logical AND gate, which detects the coincident activation of glutamate inputs, presumably encoding contextual information related to ...
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Advances in Biomaterials for Drug Delivery
... Controlled Drug Delivery The need for materials for controlled drug release arose from the general problems associated with conventional dose delivery ...Generally, drug administration required ...
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