Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and

The effects of exogenous insulin on somatostatin secretion from the isolated perfused rat pancreas have been investigated in the presence of 5.6 mM glucose and when

Supplementary Table S3: Quantitative data related to the transcriptomic profiles of the electron transport chain machinery and related mitochondrial carriers in human islets

Lipotoxic, glucotoxic, and glucolipotoxic conditions applied to human islets induced specific expression changes in solute mitochondrial carriers and associated genes, TOM/TIM

F IG. Induction of WT-HNF1␣ and DN-HNF1␣ regulates the HNF1␣ mRNA expression and HNF1␣ promoter luciferase activity through altered HNF4 ␣ binding. A, for EMSA, the

Conclusion—Foxa2 exerts the following functions in pancre- atic endocrine cells: 1) maintaining the high affinity hexoki- nase expression at a minimal level to limit insulin

To this end isolated human pancreatic islets, exposed to chronically elevated palmitate concentrations for 0, 2 and 7 days, were functionally characterized and their levels of

(A) Pancreatic endocrine cells were analysed by confocal microscopy after double labelling with an antibody against insulin, glucagon, somatostatin or pancreatic polypeptide (green)

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice... Buhler