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Receptor activator of nuclear factor-kappa B ligand (RANKL) stimulates bone-associated tumors through functional RANK expressed on bone-associated cancer cells?

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Academic year: 2021

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Figure

Fig. 1. Representative RANK immunostaining in human osteosarcoma samples. RANK can be localized in the nucleus (A), cytoplasm (B) or concomitantly in both cytoplasmic and nuclear compartments (C) of tumor cells
Fig. 2. Schematic presentation of the downstream signal transduction pathways activated by RANKL in RANK-positive cells.
Fig. 3. Schematic presentation of the tumor bone environment. RANKL induces  RANK-positive secondary bone tumor cells migration, but not in RANK-positive primary bone tumor cells

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