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A Bayesian framework for high-throughput T cell receptor pairing

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Academic year: 2021

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Figure

Figure S1. Robustness on varying degrees of simulated noise. Simulations were performed using the default simulated repertoire and sample (1000 clonotypes, 96 wells, 100 cells/well, power-law distribution, α = 2).
Figure S2. Performance of MAD-HYPE over clonal populations with varying dual clone probability
Figure S3. Performance of MAD-HYPE over clonal populations with varying skew in the distribution of clonal frequencies
Figure S4. Performance on constant frequency distributions and sensitivity to priors. To demonstrate the algorithm is insensitive to distribution type, we simulated repertoires with a constant clonal frequency, and used MAD-HYPE to deconvolute samples with
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