Hormone Therapy and Venous Thromboembolism: Early Results from the E3N Prospective Study

Download (0)

Full text

(1)Hormone Therapy and Venous Thromboembolism: Early Results from the E3N Prospective Study Marianne Canonico, Agnès Fournier, Laure Carcaillon, Valérie Olié, Geneviève Plu-Bureau, Emmanuel Oger, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Pierre-Yves Scarabin, Françoise Clavel-Chapelon. To cite this version: Marianne Canonico, Agnès Fournier, Laure Carcaillon, Valérie Olié, Geneviève Plu-Bureau, et al.. Hormone Therapy and Venous Thromboembolism: Early Results from the E3N Prospective Study. Nutrition, Physical Activity, Metabolism Conference 2008, Mar 2008, Colorado Spring, United States. �inserm-00289239�. HAL Id: inserm-00289239 https://www.hal.inserm.fr/inserm-00289239 Submitted on 20 Jun 2008. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2) 

(3)       !#"%$&')(+*,"-/. 0 "213546, 17 

(4) *98:<;90 =>16$@? BA+17 CED0FHGIDKJ0J,L5M DKJONPJOGIQ6NPRSTJ>UTL6FWVYXZ\[K]0R^_GI`a`bLdcde>Ggf2RhFHDKJiQHL7jlknmoJ>p6U_hlNKe>FHJOGbL6FWRSTJOUTL6FqVYrsSdt3]PR^_GI`g`uLvcweiGgf2R hlFWDoJ>QWL3jxDKe,FWLyMzDPF6QWDPGg`I`INPJ>R'^_DP`I{|FWGgLy}_`IGb{~R>~LWJ,L€>GIpd€>L‚l`ge0ƒ@„zeiFHL|DKe>R'STJOUTLqFHV X†ZK[P]PR'^GI`I`ILTc&e>Ggf%R0hlFHDPJOQWLKj r‡V5VˆDKJ'e>L6`0}~mPL|FWRP_r‰#„z}yR\M DŠ€>DK`bLz„`‹DKJ>Q6ŒOL~NKUdŽ>R7„‡F6L6UdRKhlFWDKJ,QWL3j,‘K’0`a€>GILzC“L6UTFHGIJOLqRKCED'FWGILHƒwMzŒ>FWG‹U&2G‹J>L „NKe02FHNPJ'ƒseODKeO`bwR0SdJ,U”L7FWV)r•snS%tP]0R'^Gg`–`‹L”cdeOGIfwROhlFWDKJ,QWL3j,‚#GIL|FHFWLHƒ—z€0L6U ‘OQWDPFWDP˜OGgJ>ROSdJ>UTL6F6V™XZK[P]PRP^nGg`I`ILTc&eiGgf2R hlFWDoJ>QWL3j3hlF6DKJOšqNPGaUdL‡Mz`‹D7€oL6`aƒwMzŒ>D0ŽOLH`bNKJjPS”J,UdL6FqV›rsSdtP]0R6^_GI`a`bLdcde>Ggf2R7hlFWDoJ>Q6L ¿¬Âœžµz ®£aªoŸT©\ Ÿd¤H¯d¡W´|£O¢@¦6£g¤6©ˆ¥²,¤|¦6£a@©\¡T¡d¯”¡§¨¡d@§6£I¤6©|£l´6¡dÀ\£b2¡Ÿ&Ÿ&£@ªq¤6Ÿ«­²,©\¡W¬®Ÿ&§|¢±£I³\¯d¡y¤6¡W¦|ŸT¢@¡&©K¢w§n¡T¤W¢½žŸdÀ6£I§ˆ©|µ ¡£I¬·©\§Š2Ÿd¬I¬I£¢±¢±£I°5£IŸdŸd¤6£b§\¬·²¤6¢-§n³|À|¡&¡%¬a§\@¢µ¤H§\´3Ÿd¤H¢ £,¡T£a²g©|´Š¢-¥£a a¤Š ®«_¤qµ‡¦7¡T¶\¡%¢-§ˆ¤6£¥Ÿ&¡dµ¶Kµz –Ÿ%¬I¶\¢±«¨¤|©\ ·¡d¶P¬u¢2ÀK¡yµ!¾\¢wÃa§yŸT¸g¹‡²‹¡ŸTºOÀ6½À|»O¬Â¬·¼£‹£I¬–©ˆ¤HŸd§\µ @ÁK¡W¤H¢±À|§\ª3Ÿd¦¨¡d£bŸ¯dª\£¤6¤|£I§¤¨¢-£I£·µ ©\£I©6¡¡&§Š¤W@¤Š¤|µzª7 ®¡z¶PŸ¤W´\¤6£‹¢2²,¬®Ÿd¯¯T ¤H2½¬Iµ‡¢±¤6°3¶\µÁ'¬·§P£I¡&©K¡”§>À ¡ ¾ ª|ª\¤|¤6¢±¦6£Iµ+¡W¢@¡&£‹§\¤q¤H¦7ª\¡%§3Ÿd´\¢­¢%ŸdŸ& 7¡

(5) ½#¤H¢wµ¯TŸd¡d@§z¯T¡W¶\¾¤HÄŝ@§‡¡Æ¶\¡d´\£g½#¢w¡”¡dÀÇ¡d§£I©|Ҕ¡ÐHÓ\À|Ï Ÿd£¥Ÿ&Ÿ9§KÀy²‹Ò%¤HÐ|µÈÏ6ԇ£g©ŠŸÕ§\¡Àz»,²b¤|ÉW gÊÌ ®¤7½#Ë7¡d£a´\ÀÀT¶|«\« Á ¶KŸ¬uŸ&ÍK§7§q¡d´\§|Ÿv¯% ®©Ç Â«֊ª\´Š@¤\¡T¢¥¢-ª\£b¬·¡T¤6¯%§6£‹§\¬®³|ŸT¡¬·¥¡W¯”¢¤Š¢-©Š¡d¤H§6@£0£y²g¤6¤6²5µ×Î6ÏqҔÐ7ЊъÐqÉÔ ¸aŸ&µ §\À ¡WŸ&Ú|§ ÎWφÀ6´6À|2¡”Ÿ&¡d£b¬aª¤W§0³|Ø'¡T¬ÂҔ§ ÔK£I¾ Ñ©6«K¤H¡Tµ‡Ÿ&2¶P¢w¤|¼¢w¾v¬–ÄÙ¢Õ¼¾|¡º'¬·À|©|¡%¡§6@£@¡T¬a²@ –¬–Ÿd¡d£IÀ¬·³|ÐK¡ÎT@Ñz¬I¢±°3½#¢¤Š¸‹µ+Û¡&Û§ ¼½‡Ÿd§|¬Â£gÀ ©†Ð6ŸžÏ|²@ܬ2¢±£0¯T¤HÀ6§\¤|²b¯&¬a´|À6µ ¡d§|¡d¯W§q¡£‹¡”¬ÂÀz§7£u¹‡¡vbºO³P»ˆŸd u¢¸%Òd¸@ÐqÝÞЕÃb¼iªK½•´Š ·¡&µ ¡¤H§3¡TŸ&¢-£bb¬·« µ¡dŸdµz£I¡T¶3Àz¤6´\ a¬–¢w¢Õ¬aµ†§|¦ ¢ ª\ŸzÒT¡d¾ äµz@¬–¤6´|¸IÀPÐ| ®£‹Ï6¾W¬Â³3ÜÈ ÝŸ&¤6w¬–µzÝŸd£Iª3Ã-¡؇Ÿ&ÝÞÒH¡d¾¤WÀzÉHß~å|½Ó'ª|¬Â¾£IÔ7©z¤T¼ªP§|¤HŸ&¤6§\@§\£uÀE¬aãg¤H´7§3ÒH¢ÕŸd¡d¾ Ô

(6)  '2¢2©3Áq¸‹Ð6Ÿd£–©KàWÏ|Ÿ&¡#ÜyÛÀ|Ý¢žÛ9ÐØlµ ²‹Ô3¤6¤|0¾®À6Ψ¹‡¡T –åºO¢ÒT»¨Ÿv¾ Ó|²I¬·£‹¼§¡dÁ杯TŸd´6¡Àw¢2@á-ª\@¡d´3¡”§q¢±¯d£I£K£‹µ ¬Â´3³\¡%¢-¡d¡d§7 ®«'£¢¾,²b¤|¤Š¿²0lµ ¤6¤W¤6¶PŸT§|¡T P¦Å¢wŸ&¬Â£I§\«\¤HÀ2Á'ŸT£aªP2 ŸdŸd¡§\@¬®¢2¢-£®£–«PÀ|¤6Á'¡%@¦|¡Tµ¡&ÀH§\´ŠŸd¢ P¯WŸ&¡T´3£‹¢-¬–¢-£a¤H¡d§ˆ¤q¢”¦7 aÁæ¡%¡%§z³|£I©|¡W£I¡d©| ,¥¡d¡çŸ±§ŠŸ½•Àâªq«†ŸW£b¢n¬·µ+½§ŠŸH¡W¤ ¢ã ½¢-¸IÛ¬–¦H¬®£aÛ§\©Åë\¬·²ÔK¡d¬a¯T¬®¾Â£gÐKŸd©Š§6ì#¡v£æ‡Ð6À7Ï6µ¬®Üy²@²@¬·¯d¡dݝ@Ã-¤H¡dØl§Š§\¯H¬IÔP¢¡¾¡TäíÀ­¬è§éåª|¹‡ÒT¾¤6É7ºê¦|Ál»9¡TÛ¢±£bÛ¡d¬I¢@@ë\°5¤6ÔK§|ŸT¾ ¡éÐK¯&ì#¤H¤|Ð7z¢%Ï6¢ª\Üy@Ÿd¡T aÝ O¦HÃ2§3ª|ØlŸ&¤6§|Ô3¦|¡é¾ ÚH¡Tå,À|¢-£IÒT¡&¤6¾I¦6҈¬Â³P¡dŸ&Ÿ&§ç£b§\¬·³Š¢±À9´6¡T¶\¢†Ûl¦HÛ꽇¤Hë,ŸT´qÒW¢ ªP¾ ÔP§|¢dì¾3¤6º'£‡Ðq2Ï7¢-Ÿ&¬aÜȧP¦6§|¢@À6¬aݲb¡d¬aÃ2@¯T؞µ†Ÿd§6ÔKŸd£b¾ êÚv Â«

(7) å¡W¢@ÒTŸH£g¾¢2É7¤q¢ÕÁ¦6¤q¡d¯T¡T§5¬aŸd¢-£Iª\Ÿd¡T¡T aÀ­¤W¯&§K£b½¬è¡³\¬®¡”£a¤H ·©9#«|¼¯T¹‡¤H½lºOµz©\»Ç¶\¡d¬·w§Š¡¬–¡T¢-ŸH°À ¢ £a¬Â§\2Ÿ&¯&§32¡T¢-À|ŸW¢-¡%¡T@µÀŸd¹‡ ,ºO¡T»­¢-£a¤6¬–¢-¦|°é¡%§¨¸gÛ¯”Û¤7µ‡ë,ÒT¶K¾ ¬®ÑP§|ì0¡TÐ6À~Ï|½#Üy¬·£aÝ©éÐØ¡W¬èÒT£I©|¾‹Ò¡då,ÒH§|¾ÂΤ|‹Ÿ&ª\§Š@À_¡T¦HÛ§\ÛêŸ&§Šë\¡ ÉP¾À7ÔP¡%ìPwÐ6¬Â³3Ï|Ÿ&Ü_£b¬·³|Ý¡TТؤHÒT¾ ÉH§\åP¤HÚK@¾ É|£I¡WÁ7¢±£b¡T¤|¢-¢-ª\£I¡d¡T¥¯&¤6£b§|¬·³Š¡ ¡d ®À|«7¡&¼w2¾\¬è³3˧yŸ&£b¯”¬·³|¤Š¡§Š¢¯H Â¢w´3¬a¦W¢-¬a§K¤H¬–§o²-¬®Á7¯W£gŸ©Š§|¡T£I¢&  « ¡ À|À6¡dŸd£u£u¡dŸ~‹µ¯T¤H¬·§|§\²@Ÿd¬®§6@µ!£¥¢ž¤6£–©P²Ÿ&£–£l©K¡£I©|¹‡¡_ºO¤H»­´|@£I¬u¡y¢2°~¤|²Ÿ&µ ¡¢-¤6£g§|¥¤|¦ ¦6ªK¡&§í¤\¢±£IŸvµ+ÀWµ¡&§\¬·§|¤Hª3¬I¢±Ÿ&£I2´\Ÿ&¢w£bŸd¬®¤7 '§í½#¤6ŸTµ ¢+¡d½#§y¡H ®½l ©|ŸT¤¢z´3£I©|¢-¡¡_©\£a«6¤Hª\µ ¡y¤W¤7§|²¡ª|£I©|¤6¡d¦|2¡TŸ&¢-ªq£I«'¤|¾\¦6º'¡%§­2Ÿ&µ†§3¢-Ÿ&À|«­¡&@¶\µ†¡yŸd '¬aµz¡W¢±ª\£I¤6¤6‹£b¦|Ÿ&¡%§|§ £ ¥Ÿd¬I a¢-¤W°P§K¾ ¡l¤H>¯T¤6µz¶P¬Â§\¡dÀz½#¬·£I© ¡T¬·£I©|¡%,µ¬·¯d¥¤Š§\¬I¢¡TÀª|¤6¦|¡T¢-£I¡d¥¤Š§Š¡¤6'ª|¡d¦6§\Ÿd§|¡lÀ|¡&¬Â³PŸ&£b¬Â³\¡T¢iµnŸ%«z¶\¡¢wŸT²‹¡½¬·£I©z¥¡W¢±ªP¡”¯d£K£b¤¹‡ºO».

(8)

Figure

Updating...

References