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Multimodal Neuroimaging in Alzheimer's Disease: Early Diagnosis, Physiopathological Mechanisms, and Impact of Lifestyle

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Academic year: 2021

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Fig. 2. Hypothetical model illustrating the links between the main AD biomarkers and the underlying neuropathological processes
Fig. 3. Schematic representation of the graded effect of APOE4 on structural MRI (atrophy), FDG-PET (metabolism), and molecular (A ␤ deposition) cortical changes
Fig. 4. Comparison of the rate of atrophy over two years between cognitively intact older adults with (PIB+) and without (PIB-) A ␤ deposition in their brain (as measured with PIB-PET) (Left)
Fig. 5. Regional variation in the degree of biomarkers. Some regions show predominant atrophy (left panel), others have higher hypometabolism than atrophy (middle panel), and A ␤ deposition predominates in other areas (right panel)
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