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Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells

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Academic year: 2021

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Fig. 1 Structure and composition of SAHF. a Fluorescent microscopy visualization of proliferating (empty) or senescent human diploid  fibro-blasts induced into senescence with H-RasV12 overexpression (Ras).
Fig. 2 SAHF formation and PML-NBs dynamics. In proliferating cells, two pathways regulate H3.3 deposition into chromatin independently of DNA synthesis
Fig. 3 Model for the role of lamin B1 (LMNB1) in SAHF formation. In proliferating cells, LMNB1 forms a filamentous structure beneath the inner nuclear membrane (INM), which is implicated in the integrity of nuclear structure and regulation of gene expressi
Fig. 4 Altered epigenome in senescent cells. This figure presents a model for how the altered epigenome in senescent cells may contribute to the senescent phenotype

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