An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.

Keywords: insulin receptor, transmembrane domain, dimerization, free energy of helix-helix association, protein-protein interactions in membrane, dimer structure

- Identifier quelques interactions des êtres vivants entre eux et avec leur milieu.. - Développement

To further investigate the mechanisms for the defective TLR4-induced NF␬B transcriptional activation in casp8 ⫺/⫺ B cells, nuclear translocation of the NF␬B-p65 subunit was

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in

To examine if undifferentiated MDSC could differentiate in vivo into functional beta cells, MDSC were isolated from a donor mouse expressing mCherry under the control of the rat

Overexpression of a dominant-negative IGF-IR impairs both IGF-I and insulin signaling in skeletal muscle To determine the functional effect of overexpression of the

Although ablation of Pten appears dispensable for Sertoli cell proliferation and spermatogenesis, inactivation of Pten in the absence of Insr and Igf1r rescued the Sertoli

In individuals with a family history of type 2 diabetes, mitochondrial respiratory function may be sufficient during a normal workload, but may deteriorate under condi- tions that