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At the beginning of implementation, or immediately prior to it, those responsible for carrying out a programme should review the plan of action and confirm or refine

Most of the evidence available supports a concept where ER stress signaling is involved in the adaptation and survival of cancer cells to stress conditions [6];

Chop is a transcription factor of the CAAT Enhancer Binding Protein (C/EBP) family. It has a dual role, acting either as a dominant negative inhibitor of C/EBPs or as a

In particular, when homeostasis cannot be restored, p53 (1) transactivates several genes coding for cell cycle-arresting factors (e.g., CDKN1A) and proapoptotic proteins (e.g.,

At the cellular level, lipid-induced skeletal muscle insulin resistance has been associated with ceramide accumulation, DiAcylGlycerol (DAG) generation and Protein Kinase C

In contrast to the non-catalytic amylase-like triads, structures of this second category have to bear a triad composed of a His residue in its protease-like

Unfolding of the S2 strand is promoted by F508del and correlates with NBD1 stability

Hepatocarcinoma induces a tumor necrosis factor-dependent Kupffer cell death pathway that favors its proliferation upon partial hepatectomy .... Complementary