• Aucun résultat trouvé

YeastMed: an XML-Based System for Biological Data Integration of Yeast

N/A
N/A
Protected

Academic year: 2022

Partager "YeastMed: an XML-Based System for Biological Data Integration of Yeast"

Copied!
15
0
0

Texte intégral

(1)

!"#$%&"'()#*)+&,-.#$"')/0$%"1)234).5363758#6)9#%#) :*%"74#%53*)32)!"#$%))

!"#$%&&%'()*'&+,$-.(/&0&*(1&**&2+,'-.(!0'3$(/$*4&4'5.(670&$%89&:&78;$%<&#=5.(

>=7?(@A(!%#&3&81=3B$75.()&#*(;A(C=77'(D&77&3'-(&3#(/,&%'#(E&'*'3'-((

-;$F&*B0$3B(=G()'=%=<H.(@&+I%BH(=G(J+'$3+$7(&3#(K$+,3'LI$7.()MN(O-P(8(Q3':$*7'BH((

!"#$%0&%$2(R77&S#'.(K&3<'$*A(1=*=++=A(

5;$F&*B0$3B(=G(T=0FIB$*(E&3<I&<$7(&3#(T=0FIB'3<(J+'$3+$.(D'<,$*(K$+,3'+&%(J+,==%(=G(

T=0FIB$*(J+'$3+$(R3<'3$$*'3<(Q3':$*7'BH(=G(1U%&<&.(5VWX-.(1&%&<&.(JF&'3.(

Y&Z"*'&+,$.(02&0&*.(2$*4&4'.('70&$%.([G&0\]%++AI0&A$7(

"&#**=77']<0&'%A+=0.(/,&%'#%&'*'3']H&,==A+=0(

;<$%4#8%=( !( 2$H( <=&%( =G( "'='3G=*0&B'+7( '7( B=( +*$&B$( #&B&"&7$( 7H7B$07( &3#(

7=GB^&*$( F%&BG=*07( +&F&"%$( =G( 7B=*'3<( &3#( &3&%H7'3<( %&*<$( 7$B7( =G( "'=%=<'+&%(

#&B&A(DI3#*$#7(=G("'=%=<'+&%(#&B&"&7$7(&*$(3=^(&:&'%&"%$(&3#(F*=:'#$(&++$77(B=(

,I<$( &0=I3B( =G( "'=%=<'+&%( #&B&A(( J_;.( `$&7B*&+B.( T`_;816MJ.()'=_*'#( &3#(

M,=7F,=_*'#( &*$( G':$( =G( B,$( 0=7B( :'7'B$#( #&B&"&7$7( "H( B,$( H$&7B( +=00I3'BHA(

K,$7$(7=I*+$7(F*=:'#$(+=0F%$0$3B&*H(#&B&(=3("'=%=<'+&%($3B'B'$7A()'=%=<'7B7(&*$(

"*=I<,B(7H7B$0&B'+&%%H(B=(LI$*H(B,$7$(#&B&(7=I*+$7('3(=*#$*(B=(&3&%H7$(B,$(*$7I%B7(

=G( B,$'*( $aF$*'0$3B7A( )$+&I7$( =G( B,$( ,$B$*=<$3$'BH( =G( B,$7$( 7=I*+$7.( LI$*H'3<(

B,$0(7$F&*&B$%H(&3#(B,$3(0&3I&%%H(+=0"'3'3<(B,$(*$BI*3$#(*$7I%B('7(&(+=0F%$a(

&3#( %&"=*'=I7( B&72A( K=( F*=:'#$( B*&37F&*$3B( &3#( 7'0I%B&3$=I7( &++$77( B=( B,$7$(

7=I*+$7.(^$(,&:$(#$:$%=F$#(&(0$#'&B=*8"&7$#(7H7B$0(+&%%$#(!"#$%&"'A(63(B,'7(

F&F$*.(^$(F*$7$3B(!"#$%&"'(G=+I7'3<(=3('B7(&*+,'B$+BI*$A(((

>"0?34'$()J$0&3B'+( b$".( `$&7B1$#.( J)8/c1.( `$&7B.( b$"( J$*:'+$7.( ;&B&(

63B$<*&B'=3A(

@))):*%43'A8%53*)

K,$(0=7B(^$%%823=^3(&3#(+=00$*+'&%%H(7'<3'G'+&3B(H$&7B7(&*$(B,$(*$%&B$#(7F$+'$7(&3#(

7B*&'37(=G(J&++,&*=0H+$7(+$*$:'7'&$A(9=^&#&H7.(B,$(^=*#(H$&7B('7(^'#$%H(<':$3(B=(B,$(

7F$+'$7( J&++,&*=0H+$7( +$*$:'7'&$( "$+&I7$( =G( B,$( F%&+$( 'B( B&2$7( '3( E'G$( J+'$3+$A(

J&++,&*=0H+$7(+$*$:'7'&$('7(3=^(*$+=<3'4$#(&7(&(0=#$%(7H7B$0(*$F*$7$3B'3<(&(7'0F%$(

$I2&*H=B$(^,=7$(<$3=0$(+&3("$($&7'%H(0&3'FI%&B$#A(E'G$(J+'$3+$('7(<$3$*&B'3<(%&*<$(

&0=I3B7( =G( #&B&( +=3+$*3'3<( J&++,&*=0H+$7( +$*$:'7'&$( B,&B( ,&:$( "$$3( 7B=*$#( '3(

0I%B'F%$( #&B&"&7$7A( )'=%=<'7B7( &*$( "*=I<,B( 7H7B$0&B'+&%%H( B=( LI$*H( B,$7$( 7=I*+$7( '3(

=*#$*( B=( &3&%H7$( B,$( *$7I%B7( =G( B,$'*( $aF$*'0$3B7A( K,$H( 0I7B( F$*G=*0( &B( %$&7B( B,$(

G=%%=^'3<( B&727( #I*'3<( LI$*H( G=*0I%&B'=3( &3#( $a$+IB'=3N( d'e( '#$3B'GH( &FF*=F*'&B$(

7=I*+$7( &3#( B,$'*( %=+&B'=3.( d''e( '#$3B'GH( B,$( G=+I7( =G( $&+,( 7=I*+$.( d'''e( LI$*H( $&+,(

+=3:$3'$3B(7=I*+$('3#$F$3#$3B%H(I7'3<('B7(7F$+'G'+(&++$77(0$B,=#(&3#(LI$*H(%&3<I&<$.(

d':e( 3&:'<&B$( B,*=I<,( B,$( 7=I*+$7( B=( ="B&'3( +=0F%$0$3B&*H( #&B&.( &3#( d:'e( 0&3I&%%H(

(2)

!"#$"%&'"%#"()*&(%+,&-./"0%1#+!%0.11"#"/&%(+)#2"(3%4'.(%5*-2"(%-%,)#0"/%+/%,.+*+$.(&(6%

!+(&%+1%7'+!%-#"%/+&%,.+./1+#!-&.2(%"85"#&(6%-/0%*.!.&(%&'"%)("%&'-&%2-/%,"%!-0"%+1%

&'"%-9-.*-,*"%./1+#!-&.+/3%%

4'"% 2'-**"/$"(% +1% !+0"#/% ,.+./1+#!-&.2(% #"("-#2'% .(% /+&% +/*:% (&+#./$% 0-&-% ./%

#"5+(.&+#."(6%,)&%-*(+%5#+2"((./$%-/0%./&"$#-&./$%&'"!3%;)*&.5*"%(+*)&.+/(%&+%,.+*+$.2-*%

0-&-% ./&"$#-&.+/% '-9"% ,""/% 0"9"*+5"03% <"("-#2'"#(% '-9"% 2+!"% )5% 7.&'% (+!"%

-55#+-2'"(% &'-&% ./&"$#-&"% 0.9"#("% ,.+*+$.2-*% 0-&-% (+)#2"(3% 4'"#"% -#"% !-./*:% &7+%

./&"$#-&.+/% -55#+-2'"(% ,"./$% )("0% ./% -00#"((./$% &'"% .(()"% +1% &'"% ./&"#+5"#-,.*.&:%

,"&7""/% ,.+*+$.2-*% 0-&-,-("(=% 0-&-% 7-#"'+)(./$% -55#+-2'% >?@% -/0% !"0.-&+#A,-("0%

-55#+-2'%>B@3%

4'"% 0-&-% 7-#"'+)(./$% -55#+-2'% .(% -0+5&"0% ,:% /)!"#+)(% ./&"$#-&.+/% (:(&"!(% *.C"%

DEF%>G@%-/0%H.(2+9"#:I./C%>J@3%4'.(%-55#+-2'%)("(%-%0-&-%7-#"'+)("%#"5+(.&+#:%&'-&%

5#+9.0"(% -% (./$*"% -22"((% 5+./&% &+% -% 2+**"2&.+/% +1% 0-&-6% +,&-./"0% 1#+!% -% ("&% +1%

0.(&#.,)&"06%'"&"#+$"/"+)(%(+)#2"(3%H-&-%1#+!%&'"%#"!+&"%'"&"#+$"/"+)(%0-&-,-("(%-#"%

2+5."0%+/%-%*+2-*%("#9"#%-/0%&'"%)("#%7.**%)("%-%)/.K)"%./&"#1-2"%7.&'./%&'"%(:(&"!%&+%

-**+7%!)*&.A0-&-,-("%K)"#."(%&+%,"%.(()"0%&+%&'.(%(./$*"%./&"#1-2"3%%

L%!"0.-&+#%0+"(%/+&%(&+#"%-/:%0-&-6%,)&%.&%5#+9.0"(%-%9.#&)-*%9."7%+1%&'"%./&"$#-&"0%

(+)#2"(3%4'"% !"0.-&+#%-55#+-2'%,-(.2-**:%&#-/(*-&"(%&'"% )("#%K)"#:6%./&+%K)"#."(%&'-&%

-#"% )/0"#(&++0% ,:% &'"% ./&"$#-&"0% (+)#2"(3% M&% !-5(% &'"% #"*-&.+/('.5% ,"&7""/% (+)#2"%

0"(2#.5&.+/(%-/0%&'"%!"0.-&+#%-/0%&')(%-**+7(%K)"#."(%+/%&'"%!"0.-&+#%&+%,"%&#-/(*-&"0%

&+%K)"#."(%+/%&'"%0-&-%(+)#2"3%%

4'"%!"0.-&+#A,-("0%-55#+-2'%'-(%("9"#-*%(&#"/$&'(%2+!5-#"0%&+%0-&-%7-#"'+)("3%M&%

0+"(%/+&%'-9"%&'"%)50-&./$%5#+,*"!%-(%&'"%K)"#:%$+"(%0.#"2&*:%&+%&'"%+#.$./-*%(+)#2"3%

;"0.-&+#(% 2-/% ,"% (""/% -(% -% 2'"-5"#% -/0% !+#"% "11"2&.9"% -55#+-2'% (./2"% &'":% )("%

(2'"!-%+#%9."7%./&"$#-&.+/6%#-&'"#%&'-/%'-9./$%&+%'-9"%')$"%(&+#-$"%2-5-2.&:%&+%(&+#"%

2+5."0%0-&-%1#+!%-**%&'"%0-&-%(+)#2"(%./9+*9"03%

4'.(%5-5"#%5#"("/&(%-%!"0.-&+#A,-("0%(:(&"!%2-**"0%!"#$%&"'%&'-&%-.!(%&+%5#+9.0"%

&#-/(5-#"/&% -22"((% &+% 0.(5-#-&"% ,.+*+$.2-*% 0-&-,-("(% +1% :"-(&3% M&% 5#+9.0"(% -% )/.K)"%

./&"#1-2"% ,"&7""/% &'"% )("#% 7'+% (),!.&(% -% K)"#:6% -/0% -% ("&% +1% 1.9"% 0-&-% (+)#2"(%

-22"((.,*"%9.-%7",%5#+&+2+*(3%!"#$%&"'%#"*."(%+/%FNAOP;%>?Q@%&+%5"#1+#!%&'"%K)"#:%

&#-/(1+#!-&.+/%/""0"0%&+%#"-2'%&'"%./&"$#-&"0%0-&-%(+)#2"(3%4'"("%(+)#2"(%-#"%&'"%!+(&%

9.(.&"0%0-&-,-("(%,:%&'"%:"-(&%2+!!)/.&:=%()*+>R@6%!"#$%,#-%+>S@6%.!)*/&01(+>T@6%

234),3'+>U@% -/0%154$654),3'+>V@3% 4'":% 5#+9.0"% 2+!5*"!"/&-#:% 0-&-% +/% ,.+*+$.2-*%

"/&.&."(% W2"**)*-#% ./&"#-2&.+/6% !"&-,+*.2% 5-&'7-:(6% &#-/(2#.5&.+/% 1-2&+#(6% -//+&-&.+/%

0-&-333X3% Y.&'%!"#$%&"'6% 7"% -.!% &+% '"*5% ,.+*+$.(&(% &+% )/0"#(&-/0% -/0% "85*-./% &'"%

,.+*+$.2-*%5#+2"(("(%+1%./&"#"(&%,:%)(./$%-/%./&"$#-&.9"%(:(&"!3%%

4'.(% 5-5"#% .(% +#$-/.Z"0% -(% 1+**+7(=% -/% +9"#9."7% +/% (+!"% ,.+*+$.2-*% 0-&-%

./&"$#-&.+/%(:(&"!(%.(%$.9"/%./%&'"% /"8&%("2&.+/3%M/%F"2&.+/%B6%-%$"/"#-*%+9"#9."7%+1%

&'"% (:(&"!% -/0% &'"% #"(+)#2"(% )("0% ./%!"#$%&"'% -#"% 0"(2#.,"03% M/% F"2&.+/% J6% &'"%

./&"$#-&.+/% 5#+2"((% -*+/$% 7.&'% (+!"% "85*-/-&+#:% (2'"!-(% .(% 5#"("/&"03% 4'"% 0-&-%

!-55./$% #)*"(% &'-&% '-9"% ,""/% 0"1./"0% 1+#% ./(&-/2"(% #"2+/2.*.-&.+/% 0)#./$% &'"%

./&"$#-&.+/%5#+2"((%-#"%-*(+%5#"("/&"03%L%0"&-.*"0%)("%2-("%.(%&'"/%$.9"/%./%F"2&.+/%R%

&+% 0"(2#.,"% '+7%!"#$%&"'% 5#+2""0(% 7'"/% -% )("#% K)"#:% .(% (),!.&&"03% F"2&.+/% S%

2+/2*)0"(%&'"%5-5"#3%

(3)

!"""#$%&'$(")*+,"

!"#$ #%&'()*&+$ &,$ -*&'&.*/0'$ 10)0$ *+)#.20)*&+$ "03$ .*%#+$ -*2)"$ )&$ 3#%#20'$ 343)#53$ )"0)$

2#.2&(6$ 0+1$ *+)#.20)#$ 0$ 3#)$ &,$ "#)#2&.#+#&(3$ 10)0-03#37$ 8()$ *+$ )"#$ /&+)#9)$ &,$ 4#03)$

343)#53:$ )"#$ 02#0$ "03$ +&)$ 4#)$ "01$ 0$ 2#502;0-'#$ #%&'()*&+7$ <#$ /0+$ /*)#$ =#''$ =4/'#$

>0)0-03#$?@AB$0+1$C#03)D(-$?@@B7$$

ƒ =#''$=4/'#$>0)0-03#$?@AB$*3$0+$*+)#.20)#1$10)0$ E02#"&(3#$,&2$343)#53$-*&'&.4$

5&1#'*+.$ 0+1$ /#''$ /4/'#$ 0+0'43*3$ -03#1$ &+$ 4#03)$ 0+1$ 50550'*0+$ &2.0+*3537$

!"#$343)#5$*+)#.20)#3$*+,&250)*&+$0-&()$.#+#3$0+1$62&)#*+3$*+%&'%#1$*+$)"#$/#''$

/4/'#$62&/#337$F)$3)&2#3$/&56'#)#$5&1#'3$&,$*+)#20/)*&+$+#)E&2;3$0+1$0''&E3$)"#$

50)"#50)*/0'$ 3*5('0)*&+$ &%#2$ )*5#$ &,$ G(0+)*)0)*%#$ -#"0%*&(2$ &,$ #0/"$

/&56&+#+)7$ !"#$ 10)0-03#$ *+)#.20)*&+$ 343)#5$ /&+3*3)3$ &,$ 0$ 3#2*#3$ &,$ 62&.2053$

(3#1$ )&$ 2#)2*#%#$ )"#$ 10)0$ ,2&5$ 3#%#20'$ 1*,,#2#+)$ #9)#2+0'$ 10)0-03#3:$ )20+3,&25$

0+1$'&01$)"#5$*+)&$)"#$E02#"&(3#$10)0$5&1#'H$*)$0'3&$/&+3*3)3$&,$0$3#2*#3$&,$'*+;3$

E*)"$ #9)#2+0'$ 2#3&(2/#3$ E"*/"$ 0''&E3$ 0$ E*1#2$ #96'&20)*&+$ &,$ 0%0*'0-'#$

*+,&250)*&+$0-&()$/#''$/4/'#$/&56&+#+)37$$

ƒ C#03)D(-$ *3$ 0$ 62&)&)46#$ 066'*/0)*&+$ *+$ E"*/"$ 0$ 10)0$ E02#"&(3#$ "03$ -##+$

/&+3)2(/)#1$ *+$ &21#2$ )&$ 3)&2#$ 0+1$ G(#24$ 1*,,#2#+)$ )46#3$ &,$ 4#03)$ .#+&5#$ 10)0$

62&%*1#1$ -4$ 1*,,#2#+)$ 2#3&(2/#3$ *+$ 1*,,#2#+)$ ,&250)3$ *+/'(1*+.$ )"#$ )0-('02$ 0+1$

I>J$ ,&250)37$ K+/#$ )"#$ 10)0$ 02#$ '&01#1$ *+)&$ )"#$ 10)0$ E02#"&(3#:$ I>JL-03#1$

G(#2*#3$ /0+$ -#$ ,&25('0)#1$ )&$ 2#)2*#%#$ 0+1$ G(#24$ )"#$ 10)0$ *+$ 0+$ *+)#.20)#1$

,03"*&+7$ C#03)D(-$ *3$ *56'#5#+)#1$ (3*+.$ M#305#$ @7@$ 0+1$ (3#3$ !&5/0)$ 03$ )"#$

E#-$ 3#2%#27$ !"#$ E#-$ *+)#2,0/#$ *3$ E2*))#+$ (3*+.$ N0%0$ 3#2%'#)37$ !"#$ )0-('02L)&L I>J$ /&+%#23*&+$ *3$ E2*))#+$ (3*+.$ N0%07$ !&$ 0//#33$ 0+1$ G(#24$ )"#$ 2#6&3*)&24$

62&.20550)*/0''4:$*)$(3#3$6HVDPH¶V6DLO$3,WKDWLV-DYDL-03#17$F)$(3#3$O4MPQ$

03$ )"#$ 10)0-03#$ 3#2%#2$ R%#23*&+$ S7AS7TUV$ )&$ 3)&2#$ *+,&250)*&+$ 0-&()$ )"#$

/&22#36&+1#+/#3$-#)E##+$)"#$2#3&(2/#$62&6#2)*#3$0+1$)"#$G(#24$,&25$,*#'137$

$

!"#3#$ )E&$ 343)#53$ 62#3#+)$ 3&5#$ '*5*)0)*&+3W$ )"#$ ,*23)$ &+#$ *3$ )"0)$ )"#4$ 3)&2#$ )"#$

#9)20/)#1$ 10)0$ '&/0''4$ *+$ 0$ 10)0$ E02#"&(3#$ &2$ 10)0-03#$ E"*/"$ 2#+1#2$ )"#$ (610)*+.$

62&/#33$ 0$ )#1*&(3$ )03;7$ C#03)D(-$ 62#3#+)3$ 0+&)"#2$ 62&-'#5$ E"#2#$ M#305#$ 1&#3$ +&)$

"0%#$0$E04$)&$*1#+)*,4$)"#$3&(2/#$&,$)"#$)2*6'#3$R3)0)#5#+)3V$&+/#$)"#4$02#$'&01#1$*+)&$

)"#$2#6&3*)&247$

-""".$&/'0$("*1$+12$)"

!"#$%&"'$*3$0$5#1*0)&2L-03#1$343)#5$)"0)$/&+3*3)3$&,$3#%#20'$/&56&+#+)3$/&+)2*-()*+.$

)&$)"#$10)0$*+)#.20)*&+$62&/#33$*+$1*,,#2#+)$E0437$F+$)"*3$3#/)*&+$E#$3#))'#$,&2$0+$*+3*.")$

*+)&$*)3$02/"*)#/)(2#$0+1$0'3&$)"#$3#)$&,$)"#$10)0$3&(2/#3$*)$*+)#.20)#3:$E"*'#$*+$)"#$+#9)$

3#/)*&+$ E#$ )0';$ *+$ 1#)0*'$ 0-&()$ *)3$ /&56&+#+)3$ 0+1$ )"#$ 2&'#$ &,$ #0/"$ &,$ )"#5$ *+$ )"#$

343)#57$

(4)

!"#$ %&'&()*$+(,-./&,/0(&$

!"#$%#&#'()$('*"+,#*,-'#$./$,"#$!"#$%&"'$010,#2$+0$0".3&$+&$4+%-'#$56$7,$*.&0+0,0$./$($

0#,$./$*.28.&#&,0$,"(,$"(9#$:##&$+28)#2#&,#;$+&;#8#&;#&,)1$(&;$8)(1$;+//#'#&,$'.)#06$

!"#$(**#00$8.+&,$,.$,"#$010,#2$+0$($3#:$+&,#'/(*#$,"(,$+&*.'8.'(,#0$,3.$0#('*"$/.'20<$($

=-+*>$0#('*"$/.'2$(&;$(&$(;9(&*#;$0#('*"$/.'26$?*+#&,+0,0$-0#$,"#$/.'2#'$,.$=-+*>)1$

0-:2+,$,"#+'$'#=-#0,0$:(0#;$.&$0.2#$>#13.';0$@A#&#$.'$B'.,#+&$&(2#0C$AD$,#'20$.'$

(&1$.,"#'$3.';0$,"(,$*(&$(88#('$+&$,"#$0#('*"$/+#);0$./$,"#$+&,#''.%(,#;$;(,($0.-'*#0E6$

!"#$)(,,#'$+0$(&$.&,.).%1F:(0#;$/.'26$G0+&%$+,C$:+.).%+0,0$*(&$#H8'#00$,"#+'$'#=-#0,0$+&$

,#'20$./$,"#$!"#$%&"'$D&,.).%16$$

!"#$%&"'$ '#)+#0$ .&$ ?IFJDK$ L5MN$ @(&$ .&,.).%1F:(0#;$ 2#;+(,.'$ ;#9#).8#;$ :1$

J"(.0$ %'.-8$ ./$ ,"#$ G&+9#'0+,1$ ./$ K()(%(E$ ,.$ 8#'/.'2$ =-#'1$ ,'(&0/.'2(,+.&$ (,$

#H#*-,+.&$ ,+2#6$ D&*#$ ,"#$ -0#'$ 0-:2+,0$ ($ '#=-#0,$ /'.2$ ,"#$ 3#:$ +&,#'/(*#C$!"#$%&"'$

%#&#'(,#0$ ($ *.&O-&*,+9#$ =-#'16$ ?IFJDK$ ;#*.28.0#0$ ,"+0$ =-#'1$ +&,.$ 0-+,(:)#$ 0-:F

=-#'+#0$,.$+&;+9+;-()$0.-'*#0$:(0#;$.&$($0#,$./$2(88+&%$'-)#06$!"#0#$0-:F=-#'+#0$('#$

#H8'#00#;$+&$PQ-#'16$

!"#$%&"'$"(9#$($0#,$./$3#:$0#'9+*#0$@R(,($0#'9+*#0$/.'$-0E<$.&#$/.'$#(*"$+&,#%'(,#;$

0.-'*#6$ !"#0#$ *.28.&#&,0$ '#*#+9#$ PQ-#'+#0$ /'.2$ ?IFJDK$ (&;$ '#,-'&$ PKS$

;.*-2#&,06$ !"#$ '.)#$ ./$ ,"#$ 3#:$ 0#'9+*#0$ +0$ ,.$ ()).3$!"#$%&"'$ ,.$ -0#$ 3'(88#'$

/-&*,+.&()+,+#0$ ,.$ /+&;$ (&;$ #H,'(*,$ 0.)+*+,#;$ +&/.'2(,+.&$ /'.2$ ;(,($ 0.-'*#0$ ,"'.-%"$

,"#+'$3#:$8(%#0$.'$4!B$2#*"(&+0206$T&03#'0C$2(,#'+()+U#;$:1$PKS$;.*-2#&,0C$,.$

PQ-#'+#0$ ('#$ 0#&,$ ,.$ ,"#$ 2#;+(,.'$ 3"+*"$ *.2:+&#0$ ,"#2$ +&,.$ ($ V#(0,K#;$ .&,.).%1$

+&0,(&*#$#H8'#00#;$+&$WR46$!"#$/+&()$'#0-),$+0$8'.9+;#;$,.$,"#$-0#'$+&$;+//#'#&,$/.'2(,0$

@WR4C$PKS$.'$X!KSE6$

R(,($ 0.-'*#0$ ('#$ ()0.$ (&$ +28.',(&,$ *.28.&#&,$ +&$ ,"#$!"#$%&"'$ ('*"+,#*,-'#$

:#*(-0#$,"#1$('#$,"#$8'.9+;#'0$./$,"#$:+.).%+*()$+&/.'2(,+.&6$

$ 1.2"$#"$A#&#'()$T'*"+,#*,-'#$./$!"#$%&"'$?10,#26$

(5)

!"#$$$%&'()*+'(,$-+'+$./0*1(2$

!"# $%&# '())*"%# +*)&$,"-#!"#$%&"'# $"%*.)/%*&# 0$+*# 1*/&%# 2/%/3/&*&4# 56*7# 6/+*# 3**"#

&*8*'%*2# 0,)# 6/+$".# %6*# 9,&%# /::),:)$/%*# :),:*)%$*&# 0,)# &%(27$".# ;/''6/),97'*&#

'*)*+$&$/*4#56*&*#&,()'*&#:),+$2*#',9:8*9*"%/)7#2/%/#',"'*)"$".#.*",9*-#:),%*,9*-#

9*%/3,8,9*#/"2#)*/'%,9*#,0#;/''6/),97'*&#'*)*+$&$/*<#

ƒ ;=>#>/%/3/&*#?@A#B6%%:<CCDDD47*/&%.*",9*4,).CE<#!%#',"%/$"&#%6*#&*F(*"'*&#

,0# 7*/&%# .*"*&# /"2# :),%*$"&-# 2*&')$:%$,"&# /"2# '8/&&$0$'/%$,"&# ,0# %6*$)#

3$,8,.$'/8# ),8*&-# 9,8*'(8/)# 0("'%$,"&-# &(3'*88(8/)# 8,'/8$&/%$,"&-# 8$"G&# %,#

8$%*)/%()*#$"0,)9/%$,"#/"2#%,,8&#0,)#/"/87&$&#/"2#',9:/)$&,"#,0#&*F(*"'*&4##

ƒ 1HI;5JIK5#>/%/3/&*#?LA#B6%%:<CCDDD47*/&%)/'%4',9E<#!%#$&#/#)*:,&$%,)7#,0#

)*.(8/%,)7#/&&,'$/%$,"&#3*%D**"#%)/"&')$:%$,"#0/'%,)&#/"2#%/).*%#.*"*&-#3/&*2#

,"# *M:*)$9*"%/8# *+$2*"'*# D6$'6# D/&# &:)*/2# %6),(.6,(%# 3$38$,.)/:6$'#

)*0*)*"'*&4#H/'6#)*.(8/%$,"#6/&#3**"#/"",%/%*2#9/"(/887-#/0%*)#*M/9$"/%$,"#

,0# %6*# )*8*+/"%# )*0*)*"'*&4# 56*# 2/%/3/&*# /8&,# ',"%/$"&# %6*# 2*&')$:%$,"# ,0#

&:*'$0$'#>NI#3$"2$".#&$%*&#0,)#/#&(3O.),(:#,0#%)/"&')$:%$,"#0/'%,)&4##

ƒ P!Q;OK1=># ?RA# B6%%:<CC9$:&46*896,8%SO9(*"'6*"42*C.*")*C:),TC7*/&%CE<#

/$9&# $"# .*"*)/8# %,# :)*&*"%# $"0,)9/%$,"# ,"# %6*# 9,8*'(8/)# &%)('%()*# /"2#

0("'%$,"/8# "*%D,)G# ,0# ;/''6/),97'*&# '*)*+$&$/*4# !"# /22$%$,"-# %6*# 2/%/# ,0#

+/)$,(&#:),T*'%&#,"#)*8/%*2#7*/&%&#/)*#/8&,#(&*2#0,)#',9:/)/%$+*#/"/87&$&4##

ƒ U$,=J!># ?VA# B6%%:<CC%6*3$,.)$24,).CE<# !%# $&# /"# ,"8$"*# $"%*)/'%$,"# )*:,&$%,)7#

D$%6# 2/%/# ',9:$8*2# %6),(.6# ',9:)*6*"&$+*# '()/%$,"# *00,)%&4# I88# $"%*)/'%$,"#

2/%/#/)*#0)**87#:),+$2*2#%6),(.6#%6*#&*/)'6#$"2*M#/"2#/+/$8/38*#+$/#2,D"8,/2#

$"#/#D$2*#+/)$*%7#,0#&%/"2/)2$S*2#0,)9/%&4#

ƒ Q6,&:6,=J!>#?WA#BDDD4:6,&:6,.)$24,).E<#)*',)2&#%6*#:,&$%$,"&#,0#&:*'$0$'#

:6,&:6,)78/%*2#)*&$2(*&#,"#.*"*#:),2('%&4#X6*)*#/+/$8/38*#0,)#&:*'$0$'#&$%*&-#

Q6,&:6,=J!># 6/&# /8&,# ",%*2# %6*# )*8*+/"%# :),%*$"# G$"/&*&# /"2C,)#

:6,&:6/%/&*&-#%6*#&:*'$0$'#',"2$%$,"B&E#("2*)#D6$'6#:6,&:6,)78/%$,"#,''()&-#

/"2#%6*#*00*'%B&E#%6/%#:6,&:6,)78/%$,"#6/&#,"#:),%*$"#0("'%$,"4##

3$ 4/56/&(&'2$/7$89/:/)91+:$,+'+$9&'()*+'9/&$9&$;(+2'<(,$

!"#$%&"'#6/&#/#&*%#,0#9,2(8*&#%6/%#2*:*"2#6*/+$87#,"#YPZ#%*'6",8,.7#%,#$"%*.)/%*#

&7"%/'%$'/887# /"2# &*9/"%$'/887# 3$,8,.$'/8# 2/%/4# !"# D6/%# 0,88,D&-# D*# .$+*# 2*%/$8*2#

$"0,)9/%$,"#,"#%6*&*#',9:,"*"%&4##

3"=$ ./0*1($.1>(5+2$

56*# G",D8*2.*# 9,2*8$".# ,0# %6*# /::8$'/%$,"# 2,9/$"# ,0#!"#$%&"'# ',"&%$%(%*&# %6*#

',)"*)# &%,"*# %,D/)2&# /"# *00$'$*"%# $"%*.)/%$,"4# 5,# %6/%# *"2-# /# 2*%/$8*2# &%(27# ,0# %6*#

&,()'*&#6/&#3**"#'/))$*2#,(%#D$%6#%6*#.,/8#,0#*&%/38$&6$".#/#&%/"2/)2#%*)9$",8,.7#%,#

2*&')$3*#%6*#2/%/4#H/'6#2/%/#&,()'*#6/&#3**"#9,2*8*2#37#/"#*M:,)%*2#YPZ# &'6*9/#

B&**#/"#*M/9:8*#$"#[$.()*#\E4#I"#*M:,)%*2#&'6*9/#)*0*)&#%,#%)/"&8/%*2#&,()'*#&'6*9/#

$"#%6*#!"#$%&"'#]"%,8,.74#56*&*#&'6*9/&#/)*#',"&$2*)*2#/&#9,2*8&#2*&')$3$".#2/%/#

/"2#%6*$)#,)./"$S/%$,"#$"#2/%/#&,()'*&#/"2#2*0$"*#/#&%)('%()*#("2*)#D6$'6#)*&(8%&#D$88#

3*#)*%()"*2#37#D*3#&*)+$'*&4##

(6)

!

!"#$%&'%"!#$"%&'()!*#!)+'!,'"-)$".)!/.+'&"0%

($&% )*+*%,-./"0-1%

!"#$%&"'!1-'-!"!-')!*#!2'3!-'$45.'-!6."77'8!5(!*1$!."-'!9")"!/'$45.'-:!)*!"..'--!8")"!

-*1$.'-0!;'!+"4'!8'4'7*<'8!*('!9")"!/'$45.'!#*$!'".+!5()'%$")'8!='"-)!-*1$.'0!>+'-'!

.*&<*('()-! +58'! )'.+(5."7! "(8! 8")"! &*8'7! 8')"57-! *#! )+'! 8")"! -*1$.'! #$*&! )+'!

&'85")*$0! >+'=! $'.'54'! ?@1'$5'-! #$*&! /ABCDE! "(8! $')1$(! ?EF! 8*.1&'()-! 5(!

"885)5*(!)*!*)+'$!&')"8")"0!!>+'!$*7'!*#!!"#$%&"'!9")"!/'$45.'-!5-!8*137'G!!

ƒ H77*25(%!!"#$%&"'! )*! 1-'! )+'! 2$"<<'$! #1(.)5*("75)5'-! )*! #5(8! "(8! 'I)$".)!

-*75.5)'8! 5(#*$&")5*(! #$*&! 8")"! -*1$.'-! 1-5(%! J>EF! <$*)*.*7-! *$! K>L!

&'.+"(5-&-0! >+5-! &'"(-! <$*4585(%! )+'! "3575)=! )*! -*74'! ?@1'$5'-! "(8! $')1$(!

"(-2'$-!5(!?EF!#*$&")0!

ƒ MI<*$)5(%!-'&"()5.!5(#*$&")5*(!"3*1)!8")"!-.+'&"-!"(8!8")"!<$*4'("(.'0!>+5-!

"77*2-! &"5(7=!!"#$%&"'! )*! N''<! )$".N! *#! )+'! $')1$('8! 5(#*$&")5*(! 2+'(!

.*&35(5(%!)+'&!"(8!2+5.+!-*1$.'!5-!3'5(%!5()'$$*%")'80!

!

O)!5-!.*&&*(7=!N(*2(!)+")!"!2$"<<'$!5-!"(!5()'$#".'!)*!"!8")"!-*1$.'!)+")!)$"(-7")'-!

8")"!5()*!)+'!.*&&*(!8")"!&*8'7!1-'8!3=!&'85")*$-!PQRS0!/5(.'!)+'!%*"7!*#!,'"-)E'8!

5-!)*!5()'%$")'!8")"3"-'-!"..'--537'!45"!;'3!<$*)*.*7-T!5)!5-!.*&<7')'7=!(*$&"7!)+")!"!

2$"<<'$! 5-! .*(-58'$'8! "-! )+'! &*-)! 5&<*$)"()! .*&<*('()! *#! )+'! "$.+5)'.)1$'! *#!

!"#$%&"'! 9")"! /'$45.'-0!O)!5-!"(!5()'$#".'! )+")! $'.'54'-!?@1'$5'-! %'('$")'8!3=!/AB CDET! "..'--'-! "! -<'.5#5.! 8")"! -*1$.'T! 'I)$".)-! 8")"! "(8! )$"(-7")'-! )+'&! 5()*! )+'!

.*&&*(!8")"!&*8'7!1-'8!3=!/ABCDET!50'0!?EF!6-''!K5%1$'!U:0!!

!

!

!"#$%2'!H$.+5)'.)1$'!*#!)+'!2'3!-'$45.'-!5(!!"#$%&"'!/=-)'&0!

(7)

!"# $%%&'&("# '(# ')*# +,DSSHU¶V TXHU\ VHUYLFH WKH ZHE V*,-&.*/# *".$0/12$'*# $"#

3002&.$'&("#4,(5,$66&"5#!"'*,7$.*#834!9:#!'#&/#')*#$..*//#0(&"'#7(,#;<=>?@#'(#')*#

71".'&("$2&'A# (7# ')*# +*B# /*,-&.*:# C)&/# 34!# 01B2&/)*/# '),**# 6*')(%/D#!"#$%&!'# ')$'#

0$//*/#'(#')*# +,$00*,#')*#EF1*,A#!#$"%#,*'1,"/#&'/#$"/+*,#&"#$"#E@G#7(,6$':#C)*#

E@G#/',1.'1,*#(7#')&/#$"/+*,#61/'#/$'&/7A#')*#.("/',$&"'/#(7#')*#/(1,.*#/.)*6$:#C)*#

(')*,#'+(#6*')(%/H#(#)*+,#-.&'/$"%/(#)0$12#3.3+#&'4/0,(-&%*#$..*//#'(#')*#6*'$%$'$#

')$'#')*# +*B#/*,-&.*# /'(,*/:#C)*# 7(,6*,#,*'1,"/#')*# E@G#%$'$#/.)*6$#$"%#')*#2$''*,#

0,(-&%*/# &"7(,6$'&("# ("# ')*# 1"%*,2A&"5# %$'$# /(1,.*:# !"# (,%*,# '(# 1/*# ')*/*# 6*')(%/#

.(,,*.'2AH#;<=>?@#7&"%/#$22#')*#"*.*//$,A#&"7(,6$'&("#$B(1'#')*6#&"#$#I;JG#8I*B#

;*,-&.*#J*/.,&0'&("#G$"51$5*9#%(.16*"':#

C)*# +*B# /*,-&.*/# )$-*# B**"# &602*6*"'*%# &"# K$-$:# C)*A# ,*.*&-*# EF1*,&*/# 7,(6#

;<=>?@#-&$#')*#(#)!"#$%&'#6*')(%#(7#')*#34!#+)&.)#0$//*/#&'#'(#')*#+,$00*,:#C)&/#

&/# 6$'*,&$2&/*%# BA# $# /*'# (7# L$-$# .2$//*/# ')$'# %*7&"*# /*-*,$2# 6*')(%/:# C)*# &".(6&"5#

EF1*,A# &/# $"$2A/*%# '(# &%*"'&7A# 0,*.&/*2A# +)$'# &"7(,6$'&("# &/# /(2&.&'*%# 7,(6# ')*#

1"%*,2A&"5#%$'$#/(1,.*:#C)*#+,$00*,#')*"#5*"*,$'*/#$#/(1,.*=$%$0'*%#M1*,A#7(22(+&"5#

')*#M1*,A#.$0$B&2&'&*/#(7#')*#/(1,.*:#C)*"#&'#*/'$B2&/)*/#$#.(""*.'&("#'(#')*#%$'$#/(1,.*#

-&$#NC@G#(,#OC4#0,('(.(2/#$"%#/1B6&'/#')*#M1*,A#'(#&':#3#/*'#(7#6*')(%/#$,*#%*7&"*%#

'(# *P',$.'# %$'$# 7,(6# /(1,.*# $"/+*,/# $"%# (,5$"&Q*# ')*6# $/# $"# &"/'$".*# (7# ')*# E@G#

/(1,.*#/.)*6$#B*7(,*#/*"%&"5#&'#'(#')*#;<=>?@#&"#')*#7(,6#(7#$"#E@G#%(.16*"':#

R*$/'@*%#&/#$B2*#'(#,*72*.'#%$'$#0,(-*"$".*#BA#.$22&"5#')*#6*')(%#(#)0$12#3.3+#&'#

+)&.)#,*'1,"/#&"7(,6$'&("#$B(1'#$#/(1,.*#(,#'),(15)#')*#E@G#%(.16*"'#,*'1,"*%#BA#

%$'$# /*,-&.*/D# &'# .("'$&"/# BA# %*7$12'# $# %*/.,&0'&("# (7# ')*# &"'*,,(5$'*%# %$'$# /(1,.*:#

C)1/H#&"/'$".*/#+&')#')*#&"'*5,$'*%#%$'$#.$"#B*#$""('$'*%#+&')#')*#%$'$#0,(-*"$".*#(7#

*$.)# 0&*.*# (7# &"7(,6$'&(":# !"# ')&/# +$AH# ')*# 1/*,# &"'*,7$.*# .(12%# /)(+# 1/*,/# ')*#

0,(-*"$".*#(7#*$.)#0$,'#(7#')*#,*/12'/:###

!"#$ %&'()*&+$,-)./.01$

;&".*#+*#$&6#'(#)*20#/.&*"'&/'/#'(#5*'#&"7(,6$'&("#7,(6#612'&02*#/(1,.*/#BA#0,(-&%&"5#

$# /&"52*# $..*//# 0(&"'H# +*# )$-*# *M1&00*%#5#.6)7#8# +&')# $# %(6$&"# ("'(2(5A:# C)&/#

("'(2(5A#&/#')*#0,(%1.'#(7#')*#,*.(".&2&$'&("#(7#')*#%&77*,*"'#%$'$#/(1,.*#/.)*6$/#&"'(#

$# /&"52*H# .()*,*"'# /.)*6$:# !'# &/# $# S"(+2*%5*# 6(%*2# ')$'# .$0'1,*/# B&(2(5&.$2# $"%#

B&(&"7(,6$'&./# S"(+2*%5*# &"# $# )&*,$,.)&.$2# .(".*0'1$2# 7,$6*+(,S# .("/',$&"*%# BA#

0$,*"'=.)&2%#,*2$'&("/)&0/D# 3# .)&2%# 8/**#O&51,*# T9# &/#$# /1B/*'# (7#$# 0$,HQW¶V*2*6*"'/U#

*$.)#.)&2%#&")*,&'/#$22#(7#&'/#0$,*"'V/#0,(0*,'&*/#B1'#)$/#6(,*#/0*.&$2&Q*%#0,(0*,'&*/#(7#

&'/#(+":#

!"#')&/#("'(2(5AH#+*#)$-*#.,*$'*%#$#.2$//#)&*,$,.)A#+)&.)#&/#$#.2$//&7&.$'&("#(7#$22#

')*# B&(2(5&.$2# *"'&'&*/# 6$"&012$'*%# BA# ')*# /A/'*6:# !"# $%%&'&("H# ')*# ("'(2(5A# %*7&"*/#

'+(# 'A0*/# (7# 0,(0*,'&*/# +)&.)# $,*# 1/*%# '(# .("-*A# $%%&'&("$2# /*6$"'&.# &"7(,6$'&("#

$B(1'#')*#.(".*0'/#(7#')*#("'(2(5A:#I)&2*#')*# 7&,/'#("*#&/#%*7&"*%#BA#$# /*'#(7#(BL*.'#

0,(0*,'&*/# ')$'# 6(%*2# ')*# ,*2$'&("/)&0/# ')$'# .$"# )(2%# B*'+**"# '+(# &"%&-&%1$2/#

B*2("5&"5# '(# ("*# (,# '+(# %&77*,*"'# .2$//*/# (7# ')*# ("'(2(5AH# ')*# /*.("%# 'A0*# $,*# %$'$#

0,(0*,'&*/D#')*/*#$,*#,*2$'&("/)&0/#2&"S&"5#$"#&"%&-&%1$2#'(#$#2&'*,$2#%$'$:#

C)*#0,&6$,A#01,0(/*#(7#5#.6)7#8#?"'(2(5A#&/#'(#/100(,'#')*#1/*,#M1*,&*/:#F1*,&*/#

$,*#0),$/*%#&"#'*,6/#(7#')*#("'(2(5A#'*,6/#$"%#5#.6)7#8# .("-*,'/#')*/*# '(#EF1*,A#

,*M1*/'/#'(#')*#$00,(0,&$'*#/(1,.*/:#C)&/#0,(.*//#&/#B$/*%#("#')*#6$00&"5/#,12*/:##

(8)

!

!"#$%&'%"!#$"%&'()!*#!)+'!!"#$%&"'!,()*-*%./!0)!1+*21!"--!)+'!"(3'1)*$1!"(4!)+'!3+5-4$'(!*#!)+'!

6789':;'(3'!<*(3'=)/!

&$&% ()**"+#,%

>"?5(%! "! 4*&"5(! *()*-*%.! #"35-5)")'1! )+'! #*$&;-")5*(! *#! :;'$5'1! )*! )+'! 1.1)'&/! @+'!

;1'$1!15&=-.!=*1'!:;'$5'1!5(!)'$&1!*#!)+'!*()*-*%.!$")+'$!)+"(!45$'3)-.!5(!)'$&1!*#!)+'!

9*;$3'!93+'&"1/!8-)+*;%+!)+51!51!?'$.!=$"3)53"-!"(4!'##'3)5?'!5(!)'$&1!*#!)+'!1.1)'&!

)$"(1="$'(3.!)*!)+'!;1'$A!5)!B$5(%1!)+'!=$*B-'&!*#!&"==5(%!)+'!:;'$.!5(!)+'!&'45")'4!

13+'&"!)*!*('!*$!&*$'!:;'$5'1!5(!)+'!13+'&"1!*#!)+'!4")"!1*;$3'1/!0(!!"#$%&"'A!)+51!

=$*B-'&!51!1*-?'4!;15(%!)+'!#;(3)5*("-5).!*#!9CDE,F/!9*!5(!"445)5*(!)*!&*4'-5(%!)+'!

*()*-*%.!"(4!)+'!1*;$3'1A!2'!(''4'4!)*!'1)"B-51+!"11*35")5*(1!B')2''(!)+'!3*(3'=)1!5(!

)+'!*()*-*%.!"(4!)+'!"==$*=$5")'!'-'&'()1!$'=$'1'()5(%!)+'!5(#*$&")5*(!5(!)+'!1*;$3'1/!

@+'1'!"11*35")5*(1!"$'!&")'$5"-5G'4!5(!!"#$%&"'!B.!)+'!&"==5(%!$;-'1/!

9CDE,F! 51! 4'15%('4! )*! 4'3*&=*1'! :;'$5'1! B"1'4! *(! H8I! "==$*"3+DB"1'4!

&"==5(%1!JKLM/!@+")!&'"(1!'"3+!3*(3'=)!N"-1*!=$*='$).!5(!*;$!3"1'O!5(!)+'!*()*-*%.!51!

DYLHZGHILQHGLQWHUPVRIWKHVRXUFHVFKHPDV¶HOHPHQWV7KLVYLHZVSHFLIL'1!+*2!)*!

*B)"5(!5(1)"(3'1!*#!)+'! &'45")'4!13+'&"! '-'&'()1!#$*&! 1*;$3'1/!0(!)+51!3*()'P)A! )+'!

&"==5(%!$;-'1!2'!+"?'!;1'4!"$'!4'#5('4!"1!="5$1!NQARO/!Q!51!*('!*$!"!3*;=-'!*#!=")+!

'P=$'115*(1! *(! "! 1*;$3'! 13+'&"! 'P=$'11'4! 5(! SQ")+A! "(4!(! "! 3*(T;(3)5?'! :;'$.!

'P=$'11'4! 5(! )'$&1! *#! )+'! ,()*-*%.! )'$&1/! @+$''! U5(41! *#! &"==5(%1! +"?'! B''(!

4'#5('4V!

ƒ <-"11! F"==5(%V! 5)! &"=1! *()*-*%.! 3-"11'1! )*! 1*;$3'! 13+'&"1/! 0)! +"1! )+'!

#*--*25(%!#*$&V!

!"#$%&'()*)+$&,-.#$/-+01+$-(-23&4(#55&6#*)07 .-88)59-+:)+.)&/+:);77

W+'$'!)*#%+,-."/"0%,123#%420! 51! )+'! -*3")5*(! *#! "(! '-'&'()! 5(! )+'! 1*;$3'!

13+'&"A! 'P=$'11'4! 5(! SQ")+X! 50%2.267,8.#$$,9#/"! 51! )+'! ("&'! *#! )+'!

3*$$'1=*(45(%! 3-"11! 5(! )+'! ,()*-*%.! "(4!32::"$;20'"03",40'"<751! "(! 5()'%'$!

?"-;'!)+")!5(#*$&1!*(!)+'!3*$$'3)('11!*#!)+'!&"==5(%!5(1)"(3'/!0(!!"#$%&"'A!)+51!

5(4'P! 51! "-2".1! KYY! 15(3'! "--! )+'! &"==5(%1! "$'! 4*('! &"(;"--.! "(4! (*)!

(9)

!"#$%!#&'!(()*+,-+./!%0(.+12&'2+%!03+#2.+!"#$%&'+'(!33+#$+#2.+456+3'2.%!+&3+

!3+7$(($138++

!"#$%&'()&*+"#'()&*,'-*.&"+)/0-*.&"+)/1220 +

ƒ 6!#!#)0.+ 9:$0.:#)+ ;!00&-<8+ &#+ %!03+ $-#$($<)+ =!#!#)0.+ 0:$0.:#&.3+ #$+ 3$":'.+

3'2.%!3*+>#+2!3+#2.+7$(($1&-<+7$:%8+

3-4&567.84+)69.:4&+.);03-4&56<4%$"69.:4&+.)/0

=)&.%.>,67.84+)6?48";0-*.@"*&,6?48"/0 :.**"#@.)A"):"6+)A"B0

(!)$*+,#-)&'+.#/)$&#'+&3+#2.+9!#2+#$+#2.+.(.%.-#+&-+#2.+3$":'.+3'2.%!+12&'2+

&3+%!00.=+#$+#2.+=$%!&-+$7+#2.+=!#!#)0.+0:$0.:#)?+(!)$*+0)12%+.#/)$&#'+&3+#2.+

9!#2+ #$+ #2.+ .(.%.-#+ 12.:.+ #2.+ 0:$0.:#)+ #!@.3+ #2.+ A!(".+ $7+ &#3+ :!-<.+ !-=+

3'$#1#45+,#-)&'+6)-%+ !-=+!"#7%"$5+6)-%+ !:.+ :.30.'#&A.()+ #2.+ =$%!&-+ !-=+

#2.+-!%.+$7+#2.+0:$0.:#)*++

+

ƒ BCD.'#+ 9:$0.:#)+ ;!00&-<8+ &#+ %!03+ $-#$($<)+ $CD.'#+ 0:$0.:#&.3+ #$+ 3$":'.+

3'2.%!3*+>#+2!3+#2.+7$(($1&-<+7$:%8+

3-4&567.84+)69.:4&+.);03-4&56!4)>"69.:4&+.)/0

=)&.%.>,67.84+)6?48";0=)&.%.>,6!4)>"6?48";0 -*.@"*&,6?48"/0:.**"#@.)A"):"6+)A"B00

(!)$*+8)'4%+.#/)$&#'+&3+#2.+9!#2+#$+#2.+.(.%.-#+&-+#2.+3$":'.+3'2.%!+12&'2+&3+

%!00.=+#$+#2.+:!-<.+$7+#2.+$CD.'#+0:$0.:#)*+3'$#1#45+8)'4%+6)-%+&3+#2.+:!-<.+

-!%.+$7+#2.+0:$0.:#)*+0

!"#$ %&'()*$

9%):$;%<+ :.(&.3+ $-+ 4EFGB;H+ 12&'2+ &3+ C!3.=+ $-+ GB;I+ JKLMH+ #$+ 0.:7$:%+ N".:)+

#:!-37$:%!#&$-3+ !#+ ./.'"#&$-+ #&%.*+ GB;I+ &3+ !+ <.-.:&'+ &-7:!3#:"'#":.+ #$+ :.<&3#.:+ !-=+

%!-!<.+$-#$($<&.3H+#2.&:+:.(!#&$-32&03+!-=+!(3$+&-7$:%!#&$-+:.(!#&-<+#$+#2.+:.3$":'.3*+

O2&3+&-7:!3#:"'#":.+ &3+C!3.=+$-+!+ :.3$":'.+=&:.'#$:)H+'!((.=+4.%!-#&'+6&:.'#$:)+ JKPMH+

1&#2+ &-7$:%!#&$-+ !C$"#+ 1.C+ :.3$":'.+ 3.%!-#&'3*+ GB;I+ 2!3+ C..-+ 3"''.337"(()+

&-3#!-#&!#.=+&-+#2.+'$-#./#+$7+%$(.'"(!:+C&$($<)+7$:+&-#.<:!#&-<+C&$($<&'!(+=!#!+3$":'.3+

12&'2+!:.+!''.33&C(.+A&!+&-#.:-.#+0!<.3*+4EFGB;+%.=&!#$:+&3+'$%0$3.=+$7+#2:..+%!&-+

'$%0$-.-#38+#2.+Q$-#:$((.:H+#2.+R".:)+0(!--.:+!-=+#2.+SA!("!#$:T>-#.<:!#$:*+

!"#"+$ ,-./0-1120$

O2.+'$-#:$((.:+'$%0$-.-#+:.'.&A.3+:.N".3#3+'$%&-<+7:$%+9%):$;%<+1.C+&-#.:7!'.+!-=+

.A!("!#.3+ #2.%+ #$+ $C#!&-+ !+ :.3"(#+ 7$:+ #2.+ :.N".3#3*+ O2.+ '$-#:$((.:+ ':.!#.3+ =&77.:.-#+

#2:.!=3+7$:+=&77.:.-#+"3.:+:.N".3#3H+!-=+!33"%.3+#2.+:$(.+$7+#2.+ %&==(.1!:.+C.#1..-+

#2.+%.=&!#$:+'$%0$-.-#3*++

R".:&.3+!:.+ ./0:.33.=+!3+'$-D"-'#&A.+ 0:.=&'!#.3+ + JKUMH++ 1&#2+#2:..+ %!&-+ #)0.3+ $7+

0:.=&'!#.8+'(!33.3+&-+#.:%3+$7+9%):$;%<+$-#$($<)+12&'2+&3+:.<&3#.:.=+&-+#2.+4.%!-#&'+

6&:.'#$:)H+ =!#!#)0.+ 0:$0.:#&.3+ #2!#+ (&-@+ &-=&A&="!(3+ #$+ =!#!+ A!(".3H+ !-=+ $CD.'#+

(10)

!"#!$"%&$'( %)*%( +&,-( &,.&/&.0*+'( %#( &,.&/&.0*+'1( 2)$( "$'0+%'( #3( %)$'$( 40$"&$'( *"$(

&,'%*,5$'(#3(%)$(!"#$%&"'(#,%#+#67(8)&5)(%)$(40$"7(8*'($9!"$''$.(&,1(

!"#"$% &'()*%+,-..()%

2)&'(5#:!#,$,%(&'( ;7(3*"(#,$(#3(%)$( :#'%( 30,.*:$,%*+(!&++*"'(&,($+*;#"*%&,6(#,$( #"(

'$/$"*+(40$"7(!+*,'(%#('#+/$(%)$(40$"7(3"#:(.&33$"$,%(.*%*('#0"5$'1(<+*,'(6$,$"*%$.(;7(

%)&'(5#:!#,$,%('!$5&37(%)$(.*%*('#0"5$'(3"#:(8)&5)(%)$(&,3#":*%&#,(5*,(;$("$%"&$/$.(

*,.(&,(8)&5)(#".$"(%)$7(:0'%(;$(*55$''$.1(2)$($/*+0*%&#,(#3(%)$'$(40$"&$'(.$!$,.'(#,(

%)$(40$"7(!+*,'(%)$:'$+/$'1((

=55#".&,6( %#( %)$( 40$"7( >*( ?#,@0,5%&/$( A0$"7BC( %)$"$( 8&++( ;$( .&33$"$,%( %7!$'( #3(

:*!!&,6(&,(%)$('$:*,%&5(.&"$5%#"71((?+*''$'(8&++(;$(5#,,$5%$.(%#(%)$(D<*%)(#3(#,$(#"(

'$/$"*+(DEF(G5)$:*("$'#0"5$($+$:$,%'1(H,(%)$(#%)$"()*,.C(.*%*%7!$(!"#!$"%&$'(8&++(

;$(5#,,$5%$.(%#(%)#'$(%8#($9!"$''&#,'I(%)$(3&"'%(#,$(5#""$'!#,.'(%#(%)$(5+*''(*,.(%)$(

'$5#,.( %#( %)$( !"#!$"%71( 2)$( #;@$5%( !"#!$"%&$'( 8&++( ;$( "$+*%$.( %#( %)$( *5%&/$( D<*%)(

5+*''$'(&,(%)$(!"#!$"%71((

!"#"/% 01-,'-23)45.2(6)-23)%

2)&'(5#:!#,$,%(*,*+7'$'(%)$(40$"7(!+*,(>A<BC(*,.(!$"3#":'(%)$(5#""$'!#,.&,6(5*++'(

%#(%)$(.*%*('$"/&5$'(&,/#+/$.(&,(%)$('0;J40$"&$'(>GAKC(111CGA,B(#3(%)$(40$"7(!+*,1(2#(

*,'8$"(!"#$%&"'(40$"7C(%)&'(5#:!#,$,%(3&"'%($9$50%$'(%)$( .*%*('$"/&5$'(&,(%)$(#".$"(

'!$5&3&$.( ;7( %)$( 40$"7( !+*,1( 2)$,C( &%( #;%*&,'( %)$( &,'%*,5$'( 3"#:( %)$( .*%*( '$"/&5$(

"$'0+%'1(2)$'$( &,'%*,5$'(*"$( ,#%(&,%$"5#,,$5%$.(;$5*0'$( %)$7( )*/$( ;$$,(!"#.05$.(;7(

.&33$"$,%(.*%*('$"/&5$'1(L,(#".$"(%#("$%"&$/$( *('$%(#3(&,%$""$+*%$.(&,'%*,5$'(8$(,$$.(%#(

$'%*;+&')( "$+*%&#,')&!'( ;$%8$$,( %)$:1( 2)&'( 5*,( ;$( *5)&$/$.( ;7( %)$( #;@$5%( !"#!$"%&$'(

.$3&,$.(&,(%)$( #,%#+#67(%)*%( *"$( 0'$.(*'("$+*%&#,')&!'(;$%8$$,('$"/&5$'(&,(%)$(40$"7(

!+*,1( M&,*++7C( %)$'$( &,%$""$+*%$.( &,'%*,5$'( *"$( 3&+%$"$.( &,( #".$"( %#( $+&:&,*%$( %)$(

&,3#":*%&#,(,#%("$40&"$.1(%

#% 78(%9-8(%

L,( %)&'( '$5%&#,C( 8$( ')#8( )#8( *( 0'$"( 40$"7( &'( '#+/$.( ;7(!"#$%&"'C( *,.( )#8( &%'(

.&33$"$,%(5#:!#,$,%'(%*-$(!*"%(&,(%)&'(!"#5$''1(F$%(0'(%*-$(%)$(5*'$(#3(*(;&#+#6&'%(8)#(

&'( 0'&,6(!"#$%&"'( %#( 3&,.( &,3#":*%&#,( *;#0%( %8#( -&,.'( #3( !"#%$&,'1( 2)$( 3&"'%( #,$( &'(

"$!"$'$,%$.( ;7( NO=( 2#!#&'#:$"*'$( LLLC( *,.( %)$( '$5#,.( #,$( &'( &,.&5*%$.( ;7( '#:$(

%"*,'5"&!%&#,( 3*5%#"'( "$60+*%&,6( %)$( $9!"$''&#,( #3( %)$( 3&"'%( -&,.1( 2)$( ;&#+#6&'%( &'(

&,%$"$'%$.( &,( %)$( !)#'!)#"7+*%&#,( '&%$'( %)*%( *"$( 3#0,.( &,( %)$( '$40$,5$'( #3( %)$(

%"*,'5"&!%&#,( 3*5%#"'( #3( NO=( 2#!#&'#:$"*'$( LLLC( $'!$5&*++7( %)$( #,$( >#"( #,$'( &3( %)$7(

$9&'%B(8)#'$(6$,$(&'(+#5*%$.(#,(%)$(?)"#:#'#:$(DPL1(L,(*..&%&#,C(%)$(;&#+#6&'%(*+'#(

*&:'( %#( 6$%( *++( %)$( +&%$"*%0"$( #,( NO=( 2#!#&'#:$"*'$( LLL1( ='( '%*%$.( !"$/&#0'+7C(

!"#$%&"'( !"#/&.$'(*( 8$;(&,%$"3*5$( %)*%( *++#8'(;&#+#6&'%'(%#($9!"$''(%)$&"(40$"&$'(&,(

%$":'(#3(%)$(#,%#+#67(>'$$(M&60"$(QB1((

(11)

!

!"#$%&'%"!#$%&!'(!&)*!'+&','-./0$1*2!1*$%3)!('%45!

6)*!(%$-4*+&!'(!1*4$+&731!&)$&!71!74#,7*2!27%*3&,.!7+!&)*!('%48,$&7+-!#%'3*11!'(!&)$&!

98*%.! 71! 1)':+! 7+! ;7-8%*! <5! ;%'4! &)71! (%$-4*+&=! $! 3'+>8+3&7?*! 98*%.! 71! -*+*%$&*2!

$8&'4$&73$,,.@!!

!"#$%&'()*+,-3URWHLQ3KDV'HVFULSWLRQ3´'1$

7RSRLVRPHUDVH,,,´%LE5HI%5KDV%LE5HI3%5 ).#/0#123.1456.32$('/6*'7289:.12;%0$('<=*').#6.32$<

='61*'<7."#574>14?"=.51?7$<=*'@)7?3?#?32$@*').#6.32

&´;9,´%HORQJV7R7)&3KRVSKR6LWH3K ).#()?#>)?/412$<='()*A-

-

6)71!3'+>8+3&7?*!98*%.!7+3,82*1!$1!#%*273$&*1!(7?*!'+&','-.!3,$11*1!A!"#$%&'=!(&)*%+=!

,"-'./"&0$&#'1-/$#"=! 23"#4#.#4%! $+2! !3#.03#5&$%B=! &)%**! 2$&$&.#*! #%'#*%&7*1!

A3-.6%./"&0$&#'=! 3-.57.$%4-$&/8-4%! $+2! 3-.8-4%B! $+2! ('8%! '0>*3&! #%'#*%&7*1!

A3-.(&)*%+=!"%9:;-$%<(7=!)%;#'9.,#! $+2!3-.!3#.03#5&$%B5! 6)71! 98*%.! :7,,! %*&8%+!

7+1&$+3*1!'(!!3#.03#5&$%!$+2!(&)*%+!&)$&!1$&71(.!7&1!3'+1&%$7+&15!

"1!$!1801*98*+&!1&*#=!&)*!3'+>8+3&7?*!98*%.!:7,,!0*!1*+&!&'!CD/EFG=!%*3*7?*2!0.!

&)*! 3'+&%',,*%! :)73)! :7,,! #$11! 7&! &'! &)*! H8*%.! I,$++*%5! 6)71! 3'4#'+*+&! )$1! $+!

$,-'%7&)4! &)$&=! 0$1*2! '+! &)*! 98*%.! #%*273$&*1! $+2! &)*! 4$##7+-1! '(! &)*! 1*4$+&73!

27%*3&'%7*1=! :7,,! -*+*%$&*! $! 1*&! '(! 180/98*%7*1! $+2! $,1'! $! #,$+! &'! *J*38&*! &)*45! 6)*!

#%*273$&*1! '(! &)*! 3'+>8+3&7?*! 98*%.! $%*! 27?72*2! 7+&'! &:'! 1*&1@! $! 1*&! &)$&! 3'+&$7+1!

#%*273$&*1!:7&)!$!17+-,*!$%-84*+&!$+2!$+'&)*%!&)$&!3'+&$7+1!#%*273$&*1!:7&)!4'%*!&)$+!

'+*!$%-84*+&5!6)*!#%*273$&*1!(%'4!&)*!&:'!1*&1!)$?7+-!3'44'+!$%-84*+&1!$%*!&)*+!

-%'8#*2! &'-*&)*%! 7+&'! -%'8#1! %*#%*1*+&*2! 0.! &)*! 3'407+$&7'+! '(! &:'! '%! 4'%*!

#%*273$&*15!6)*! -%'8#1!&)$&! $%*! +'&!%*#%*1*+&*2!7+!&)*! C*4$+&73!K7%*3&'%.! 4$##7+-1!

$%*!2713$%2*2!A1**!;7-8%*!<!('%!&)*!4$##7+-1!74#,7*2!7+!&)71!#%'3*11B5!6)*!%*4$7+2*%!

71! $22*2! &'! &)*! (7%1&! 1*&! $,,':7+-! $! -%'8#! &'! 0*! #%*1*+&! '+,.! '+3*5! 6$0,*! L! ,71&1! $,,!

%*18,&7+-!-%'8#15!

(12)

Class Protein Class

ObjectProperty hasPhosphoSite Domain

Transcription factor

DataTypeProperty TopoisomeraseIII

domain

ObjectProperty RegulatedBy domain

DataTypeProperty SyastematicName domain

ObjectProperty hasBibRef

domain Class

range

Class

range

ObjectProperty BrlongsTo

domain

DataTypeProperty hasName domain

Class range DataTypeProperty

XVII

Chromosome domain

domain DataTypeProperty

hasName

BibRef

range SGD: /Result/Entries//Protein

SGD: Result/Entries//Description

Yeastract: Result/Entries//SystematicName SGD: Result/Entries//BibRef

Yeastract: Result/Entries//DocTF

Yeastract: Result/Entries//DocTF/TF_Name Yeastract: Result/Entries//Chromosome

Yeastract: Result/Entries//Chromosome PhosphoGrid: Result/Entries//PhosphoSite PhosphoGrid: Result/Entries//PhosphoSite/SiteName

Phosphorilation Site

!

!"#$%&'%"#$!%&'()$*+!,%!+#$!-*+,.,(/!0*1,2$3!+,!%,&)4.'+$!+#$!54$&/!$6')7.$8!9.'::$:!'&$!

:#,;*!0*!(&$$*!'*3!<&,7$&+0$:!0*!=.4$8!"#$!)'770*(:!=$+;$$*!+#$!,*+,.,(/!'*3!+#$!:,4&>$!

:>#$)':!'&$!7&$:$*+!'=,1$!+#$!,*+,.,(/!$.$)$*+!?0*!&$3@8!

()*+,%-$!!"#$!(&,47:!4:$3!+,!%,&)!+#$!<.'*!"&$$8!A,&!$'>#!(&,47!+#$!B'770*(!C,4&>$!0:!(01$*8!!

D&,47! E4$&/! B'770*(!:,4&>$!

DF! <&,+$0*?<@G!#':H0=I$%?<GHI@! CDJ!

DK! 3URWHLQ3KDV'HVFULSWLRQ3³JLM!

",7,0:,)$&':$!NNN´! CDJ!

DO! <&,+$0*?<@G!#':C/:+$)'+0>L')$?<G!CL@! P$':+&'>+! DQ! <&,+$0*?<@G!I$(4.'+$3H/?<G!"A@! P$':+&'>+! DR! "&'*:>&07+0,*A'>+,&?"A@G!#':L')$?"AG!L+@! P$':+&'>+! DS! "&'*:>&07+0,*A'>+,&?"A@G!=$.,*(:",?"AG9@! P$':+&'>+! DT! "&'*:>&07+0,*A'>+,&?"A@G!

#':<#,:7#,&/.'+0,*C0+$?"AG!<#@! <#,:7#,D&03!

DU! 9#&,),:,)?9@G!#':L')$&´;9,´! P$':+&'>+!

DV! &$(4.'+$3H/?<G"A@! P$':+&'>+!

DFW! #':H0=I$%?<GHI@! CDJ!

DFF! =$.,*(:",?"AG9@! P$':+&'>+!

DFK! #':<#,:7#,C0+$?"AG<#@! <#,:7#,D&03!

DFO! <&,+$0*?<@! CDJX! P$':+&'>+X!

<#,:7#,D&03!

DFQ! "&'*:>&07+0,*A'>+,&?"A@! P$':+&'>+X!

<#,:7#,D&03!

DFR! H0=I$%?HI@! CDJ!

DFS! 9#&,),:,)$?9@! P$':+&'>+!

DFT! <#,:7#,C0+$?<#@! <#,:7#,D&03!

!

A&,)! +#0:! :$+G! +#$! 7.'**$&! ;0..! +&/! +,! >,*:+&4>+! 7,+$*+0'.! +&$$:! ,%! +#$! $6$>4+0,*!

,&3$&8!N+!:$.$>+:!(&,47:!#'10*(!1'&0'=.$:!0*:+'*+0'+$3!0*!,&3$&!+,!:$+!'!&,,+!%,&!'!+&$$8!

"#$! ,&3$&! ,%! +#$! 7.'*! $6$>4+0,*! 3$7$*3:! ,*! +#$! 0*:+'*+0'+$3! 1'&0'=.$:Y! ! +#$! (&,47!

(13)

!"#$%&#&#'(%#(&#)$%#!*+(,%-&%./*(&)(*0*!1$*+(2&-)$3($4*#($4*('-"15)($4%$(%-*(-*/%$*+($"(

$4")*(,%-&%./*)3(%#+()"("#(1#$&/(%//($4*('-"15)(%-*(*0*!1$*+6(7#("1-(!%)*3(89(%#+(8:(

%-*()*/*!$*+6(8;(!%##"$()*-,*(%)(%(-""$3(.*!%1)*($4*-*(&)(#"("$4*-('-"15($4%$(+*5*#+)(

"#( &$)( &#)$%#$&%$*+( ,%-&%./*( <4&!4( =**5)( $4*( "$4*-( '-"15)( <&$4"1$( *0*!1$&"#6( >4&)( &)(

#"$($4*(!%)*(2"-(89(<4&!4()*-,*)(%)(%(-""$(2"-($4*($-**()4"<#(&#(?&'1-*(@6(7$(&)($4*(2&-)$(

$"(.*(*0*!1$*+6(>4&)(-*$1-#)($4*(5-"$*&#($4%$(4%)(%)(GHVFULSWLRQ³'1$7"5"&)"A*-%)*(

,,,´( >4*#( 8B( %#+( 8CD( %-*( *0*!1$*+( &#( 5%-%//*/( .*!%1)*( $4*E( +*5*#+( "#( $4*(

&#)$%#$&%$*+( ,%-&%./*( "2( 896( ?-"A( $4*)*( )&A1/$%#*"1)( *0*!1$&"#)3( $4*( %/'"-&$4A( <&//(

+*$*-A&#*( %//( $4*( ".F*!$)( $4%$( %-*( -*/%$*+( $"(!"#$%&'( .E( A*%#)( "2( $4*( -*/%$&"#)4&5)(

"%()*+$%,-.( %#+(/+0-&12%36( G#!*( $4")*( ".F*!$)( %-*( ".$%&#*+3( &$( <&//( !4*!=( <4*$4*-(

$4*E()%$&)2E(8CH(%#+(8CIJ($4%$(A*%#)(!4*!=&#'(&2($4*(".F*!$)(".$%&#*+(2-"A(8B(%#+(

8CD(%-*(-*)5*!$&,*/E("2($4*($E5*(4"+'05"&6$&#'7+5$#"(%#+(-&12%36(K%)*+("#($4*(-*)1/$(

"2(8B3('-"15)(8CC(%#+(8C9(%-*(*0*!1$*+(.1$(#"$()&A1/$%#*"1)/E6(LKMNGO(4%)(%(5/%#(

"5$&A&P%$&"#(A"+1/*($4%$(A&'4$(!4%#'*($4*("-+*-("2($4*(&#&$&%/(5/%#(*0*!1$&"#(%)(&)($4*(

!%)*(4*-*J(L&#!*(8;(4%)(%(,%-&%./*(&#)$%#$&%$*+(YDOXH³;9,,´%#+(&)(-*/%$*+($"(8CH(

,&%(8CC3($4&)("#*(&)(*0*!1$*+(.*2"-*( 8C93(%#+($4*(-*)1/$(&)(1)*+(.E($4&)('-"15($"(.*(

*0*!1$*+6( >4*( %-!)( "2( $4*( 5/%##&#'( $-**)( '*#*-%$*+( .E( $4*( 5/%#*-( -*5-*)*#$( ".F*!$(

5-"5*-$&*)3(<4&/*($4*(#"+*)(%-*("#$"/"'E(!"#!*5$)("-(&#)$%#!*)("2($4*)*6(Q%!4(#"+*(%#+(

%-!(!"#$%&#)(%//($4*(#*!*))%-E(&#2"-A%$&"#(2"-($4*(Q,%/1%$"-(R7#$*'-%$"-($"(*0*!1$*()1.M S1*-&*)6(>4%$(&)J($4*(TU1*-E(V*/%."-%$*+(2-"A($4*(A%55&#'W(!"--*)5"#+&#'($"($4*()1.M S1*-E("2($4*(#"+*("-($4*(%-!3($4*(#%A*)(%#+($4*(XYZ)("2($4*([%$%(L*-,&!*("2(&#$*-*)$6(

\#(*0%A5/*(&)()4"<#(&#(?&'1-*(;6(

!

!"

#$

%

&'

Protein(P)

hasDescription(P,¶¶'1$7RSRLVRPHUDVH,,,¶¶)

regulatedBy(P,TF)

belongsTo(TF,C)

PhosphoSite(Ph)

hasPhosphoSite(TF,Ph) BibRef(BR)

hasBibRef(P,BR)

Chromosome(C) hasName(C,¶¶;9,¶¶) Transcriptionfactor(TF) hasName(TF,Nt)

!"#$%&'%>4*(5/%#($-**('*#*-%$*+(2-"A($4*(!"#F1#!$&,*(S1*-E(

(

!"#$%('%>4*(&#2"-A%$&"#(5-*)*#$*+(.E($4*(#"+*(](&#($4*(5/%#($-**()=*$!4*+(&#($4&)()*!$&"#6(

(14)

!"#$!"#$%&"'$%&'&$(#)*+,#($&)#$#-#,.'#%$/0$'"#$1*&2.&'3)456'#7)&'3)$832239+67$'"#$

:2&6;$ &8'#)$ 3:'+<+=&'+36;$ 7#6#)&'#%$ /0$ '"#$ >2&66#)?$ 56$ 3.)$ ,&(#;$ @AB$ B&'&$ @#)*+,#$

)#,#+*#($'"#$8+)('$(./CD.#)0;$/#,&.(#$'"#$3/E#,'$:)3:#)'0$(#$)"$*+,-%,./$+($<&::#%$'3$

'"#$@AB$@,"#<&?$!F>G$+($)#'.)6#%$&($&6$&6(9#)$38$'"+($(./CD.#)0$&6%$'"#6$+($.(#%$/0$

'"#$ (./CD.#)0$0"123#%"'45$ '3$ 8+6%$ +6('&6,#($ 38$6+#/$*+,-%,./7#*%.+?$ !"#$ H#&(')&,'$

B&'&$ @#)*+,#$ +($ +6*3I#%$ '"+($ '+<#$ /#,&.(#$ '"#$ :)3:#)'0$ +($ <&::#%$ '3$ '"#$ H#&(')&,'$

@,"#<&?$!")##$+6('&6,#($38$'"#$'0:#$6+#/$*+,-%,./7#*%.+$&)#$)#'.)6#%J$K"2L:;$M(8L:$

&6%$@9+N:?$K3)$#&,"$38$'"#(#$+6('&6,#(;$'"#$H#&(')&,'$B&'&$@#)*+,#$+($,&22#%$&7&+6?$5'$

)#,#+*#($'"+($'+<#$'"#$(./CD.#)0$)#:)#(#6'#%$/0$'"#$:)3:#)'0$8"3./1$6.$'"&'$,36'&+6($

'"#$'93$&)7.<#6'($+6('&6'+&'#%J$'"#$8+)('$36#$+($36#$38$'"#$'")##$+6('&6,#($)#'.)6#%$/0$

'"#$ :)#*+3.($ D.#)0;$ &6%$ '"#$ (#,36%$ &)7.<#6'$ +($ +6('&6'+&'#%$ /0$ '"#$ 6&<#$ 38$ '"#$

,")3<3(3<#$ OP5?$ !"+($ (./CD.#)0$ ,"#,I($ 9"#'"#)$ '"#$ !)&6(,)+:'+36$ 8&,'3)$ "&($ +'($

,3%+67$7#6#$36$'"#$,")3<3(3<#$OP5?$F620$'"#$+6('&6,#$K"2L:$+($<&+6'&+6#%?$K+6&220$

'"#$ (./CD.#)0$ "&(>"3(:"3@+'#$ +($ #-#,.'#%$ 36$ '"#$ >"3(:"3A)+%$ B&'&$ @#)*+,#$ '"&'$

)#'.)6($ &22$ '"#$9(.$-(.:,%"$ +6('&6,#($ 38$ '"#$ !)&6(,)+:'+36$ K&,'3)$ K"2L:?$ Q'$ #&,"$

#-#,.'+36;$ '"#$ 1*&2.&'3)456'#7)&'3)$ )#,#+*#($ )#(.2'($ +6$ ORS$ 83)<&'$ 8)3<$ '"#$ '&)7#'$

B&'&$ @#)*+,#(?$ !"#(#$ )#(.2'($ &)#$ +6('&6,#($ 38$ '"#$ ORS$ (,"#<&($ 38$ '"#$ .6%#)20+67$

(3.),#(?$T&(#%$36$'"#$<&::+67$/#'9##6$'"#$#2#<#6'($38$'"#$(3.),#$(,"#<&($&6%$'"#$

#2#<#6'($38$ '"#$36'32370;$'"#(#$ ORS$ (,"#<&$+6('&6,#($&)#$ ')&6(2&'#%$+6'3$ 36'32370$

+6('&6,#($9"+,"$&)#$63'$+6'#),366#,'#%$/#,&.(#$'"#0$"&*#$/##6$:)3%.,#%$/0$%+88#)#6'$

%&'&$(#)*+,#(?$!3$&((3,+&'#$'"#<;$'"#$1*&2.&'3)456'#7)&'3)$.(#($E.('$'"#$+6('&6,#($38$'"#$

%3<&+6$ &6%$ )&67#$ ,2&((#($ 38$ '"#$ 3/E#,'$ :)3:#)'+#(?$ $ !"#$ 8+6&2$ )#(.2'$ +($ &6$ 36'32370$

+6('&6,#$'"&'$+6,2.%#($&22$'"#$%&'&$#-')&,'#%$8)3<$'"#$+6'#))37&'#%$%&'&$(3.),#(?$!"&'$+($

&22$'"#$+6('&6,#($38$'"#$,36,#:'($T+/U#8$38$'"#$:)3'#+6$!F>G$&6%$&22$'"#$>"3(:"3@+'#$

3/E#,'($38$'"#$!)&6(,)+:'+36$K&,'3)$K"2L:?$

!" #$%&'()*$%)"

V#$ "&*#$ %#(,)+/#%$!"#$%&"'J$ &6$ ORS$ &6%$ <#%+&'3)C/&(#%$ (0('#<$ '"&'$ 56'#7)&'#($

8+*#$ H#&('$ %&'&/&(#($ 9"+,"$ "&*#$ '"#$ <3('$ &::)3:)+&'#$ :)3:#)'+#($ 83)$ ('.%0+67$

@&,,"&)3<0,#($,#)#*+(+&#?$

B&'&$(#)*+,#($:2&0$&6$+<:3)'&6'$)32#$+6$'"#$+6'#7)&'+36$:)3,#(($38$'"+($(0('#<;$9"#)#$

'"#0$&)#$,36(+%#)#%$&($&6$+6'#)8&,#$9"+,"$)#,#+*#($D.#)+#(;$&,,#((#($'3$&$%&'&$(3.),#;$

#-')&,'($ %&'&$ &6%$ ')&6(2&'#($ '"#<$ +6'3$ &$ ,3<<36$ %&'&$ <3%#2$ .(#%$ /0$ @TCWFR?$ 56$

H#&('R#%;$ B&'&$ @#)*+,#($ #-')&,'$ %&'&$ <&+620$ 8)3<$ 82&'$ 8+2#($ /#,&.(#$ <3('$ 38$ '"#$

+6'#7)&'#%$%&'&$(3.),#($&)#$&,,#((+/2#$*+&$8':$<#,"&6+(<($&6%$:)3*+%#$%&'&$+6$'&/.2&)$

3)$ORS$83)<&'?$!"+($)#%.,#($'"#$,3('($38$'"#$ <&+6'&+6&/+2+'0$38$'"#$(0('#<$/#,&.(#$

82&'$8+2#($(').,'.)#($&)#$63'$8)#D.#6'20$'&)7#'$'3$,"&67#(?$

56$ 3.)$ (0('#<;$ '"#$ (,"#<&$ +6'#7)&'3)$ +($ &6$ 36'32370$ &6%$ '"#$ )#(.2'($ &)#$ 36'32370$

+6('&6,#(?$ !"#$ .(#$ 38$ '"#$ 36'32370$ &6%$ +6('&6,#($ #6&/2#($ )#&(36+67$ '3$ /#$ 2&'#)$

+6,2.%#%$&'$%+88#)#6'$2#*#2(?$H#&('R#%$,3.2%$/#$#D.+::#%$9+'"$&$)#&(36#)$'"&'$93.2%$

+68#)$ 6#9$ )#2&'+36("+:($ /#'9##6$ '"#$ +6('&6,#($ 38$ '"#$ 36'32370$ 9"#6$ (32*+67$ &$ .(#)$

D.#)0?$!"+($9+22$#6&/2#$H#&('R#%$'3$%+(,3*#)$6#9$I6392#%7#$83)$'"#$D.#)0$&6(9#)(?$

!"#$ 8+6&2$ )#(.2'$+($&6$36'32370$+6('&6,#$'"&'$ +6,2.%#($&22$ '"#$ %&'&$ #-')&,'#%$8)3<$'"#$

+6'#7)&'#%$%&'&$(3.),#(?$$

(15)

!"#$%&'()*(+($,-.

!"#$% &'()%"*$%+,,-%./-0,0% +1% 2",% 3('4,52%6789:;<=>:?% @ABCDCCDABEF%6BG9!879 BHIGE% JK/-2*% 0,% @-0*L/5M*NF% *-0% !8OHBBE9BPEPP% JQ3*-#$"% >#-#$2(1% '.% Q5#,-5,% *-0%

8--'R*2#'-NS%

/(0(1($"(-.

CS T*U+(#VF% 6SF% K*)'-#,-,F% WSX% !'&*(0$% 2(*-$3*(,-2% *55,$$% 2'% U/L2#3L,% +#'L'Y#5*L% 0*2*+*-)$F%

6('5,,0#-Y$%'.%2",%C$2%@$#*96*5#.#5%Z#'#-.'(U*2#5$%7'-.,(,-5,F%JHBBBNS%

HS ?*R#0$'-F% QS% ZSF% 7(*+2(,,F% KSF% Z(/-)F% ZSF% Q5"/YF% KSF% @--,-F%WSF% =R,(2'-F% 7SF% !',5),(2F% 7SX%

[HA[L,#$L#% *-0% \;QX% :V3,(#U,-2$% #-% 8-2,Y(*2,0% @55,$$% 2'% \,-'U#5% ?*2*% Q'/(5,$F% 8Z>%

Q1$2,U%K'/(-*LS%?,,3%7'U3/2#-Y%.'(%2",%T#.,%Q5#,-5,$F%PBS%JHBBCNS%%%

]S ^,(-*-0,_F% !SF% [*U+"*U3*2#F% QSX% 8-2,Y(*2#'-% '.% Z#'L'Y#5*L% Q'/(5,$X% 7/((,-2% Q1$2,U$% *-0%

7"*LL,-Y,$%@",*0F%Q8\>=?%<,5'(0F%]]F%JHBBPNS%

PS `'-YF%TSX%!,5"-'L'Y#,$%.'(%8-2,Y(*2#-Y%Z#'L'Y#5*LF%Z(#,.#-Y%#-%Z#'#-.'(U*2#5$F%]]EI%±%PBPF%

JHBBHNS%

aS :-Y,LF% QS<SF% ,2% *LSX% Q*55"*('U15,$% \,-'U,% ?*2*+*$,% 3('R#0,$% U/2*-2% 3",-'213,% 0*2*S%

O/5L,#5%@5#0$%<,$,*(5"F%]E%J?*2*+*$,%#$$/,NFP]]²P]DF%JHBCBNS%

DS !,#V,#(*F%>S7SF%>'-2,#('F%6SF%K*#-F%6SF%!,-(,#('F%QSF%b,(-*-0,$F%@S%<SF%>#(*F%OS6SF%@L,-c/,(F%

>SF%b(,#2*$F%@S!SF%=L#R,#(*F%@S%TSF%Qd97'((,#*F%8S%!",%e:@Q!<@7!%0*2*+*$,X%*%2''L%.'(%2",%

*-*L1$#$%'.%2(*-$5(#32#'-%(,Y/L*2'(1%*$$'5#*2#'-$%#-%Q*55"*('U15,$%5,(,R#$#*,F%O/5L,#5%@5#0$%

<,$,*(5"F%]PF%PPD²PaCF%JHBBDNS%

GS \fL0,-,(F% ;SF% ,2% *LSX% 7e\?X% 2",% 7'U3(,",-$#R,% e,*$2% \,-'U,% ?*2*+*$,S% O/5L,#5% @5#0$%

<,$,*(5"S%]]%J?*2*+*$,%#$$/,NF]DP9]DEF%JHBBaNS%

ES Z(,#2)(,/2_F% ZSKSF% ,2% *LS% !",% Z#'\<8?% 8-2,(*52#'-% ?*2*+*$,X% HBBE% /30*2,S%O/5L,#5% @5#0$%

<,$,*(5"SF%]D%J?*2*+*$,%#$$/,FD]G99PBF%JHBBEN%S%

IS Q2*()F%7SF%!#-Y97",-YF%Q/SF%Z(,#2)(,/2_F%@SF%T'/(,-5'F%6SF%?*"*+#,"F%>SF%Z(,#2)(,/2_F%ZSKSF%

!1,($F% >SF% Q*0'&$)#F% 8SX% 6"'$3"'\<8?X% *% 0*2*+*$,% '.% ,V3,(#U,-2*LL1% R,(#.#,0% #-% R#R'%

3('2,#-%3"'$3"'(1L*2#'-%$#2,$% .('U%2",%+/00#-Y% 1,*$2%Q*55"*('U15,$%5,(,R#$#*,S%?*2*+*$,S%

JHBCBN%%

CBS %O*R*$9?,LY*0'F8S% *-0@L0*-*9>'-2,$F% KS% bSX% :V2,-0#-Y% Q?97'(,% .'(% =-2'L'Y19+*$,0% ?*2*%

8-2,Y(*2#'-%SK'/(-*L%'.%;-#R,($*L%7'U3/2,(%Q5#,-5,FCaF%]HBC²]H]B%JHBBINS%

CCS %7",/-YF% [S^SF% e#3F% [SeSF% QU#2"F% @SX% e,*$2^/+X% *% $,U*-2#5% &,+% /$,% 5*$,% .'(% #-2,Y(*2#-Y%

0*2*%#-%2",%L#.,%$5#,-5,$%0'U*#-S%Z#'#-.'(U*2#5$S%%HC%Q/33L%CF%Ea²ID%JHBBaNS%

CHS %@L.#,(#F% <SF% >,(,LL#F% 8SF% >'$5*F% :SF% >#L*-,$#F% TSX% !",% 5,LL% 515L,% ?ZX% *% $1$2,U$% +#'L'Y1%

*33('*5"%2'%5,LL%515L,%*-*L1$#$S%O/5L,#5%@5#0$%<,$,*5"F%J]D%?*2*+*$,F%DPC9DPaF%JHBBENS%

C]S %7"-#+,(F%=SF%[,(_*_#F%@SF%O*R*$9?,LY*0'F8S%*-0%@L0*-*9>'-2,$F%KS%bSX%[=>bX%!",%["'*$%

=-2'L'Y19+*$,0% >,0#*2'(% b(*U,&'()% O:!!@ZHBBEX% Z#'#-.'(U*2#5$% >,2"'0$% .'(%

Z#'U,0#5*L%7'U3L,V%Q1$2,U%@33L#5*2#'-$%JHBBENS%

CPS %%O*R*$9?,LY*0'F8S% *-0% @L0*-*9>'-2,$F% KS% bSX% Q?97'(,X% \,-,(#5% Q,U*-2#5% >#00L,&*(,%

7'U3'-,-2$% .'(% 2",% Q,U*-2#5% `,+S% [:QF% 6*(2% 88F% TO7QF% R'LS% aCGEF% DCG99DHHS% Q3(#-Y,(F%

^,#0,L+,(Y%JHBBENS%

CaS W*(0#F%eSF%!",%5'U3L,V#21%'.%(,L*2#'-*L%c/,(1%L*-Y/*Y,$%J:V2,-0,0%*+$2(*52N%Q!=7X%C]G² CPD%JCIEHNS%

CDS %@S% T,R1X% 7'U+#-#-Y% *(2#.#5#*L% #-2,LL#Y,-5,% *-0% 0*2*+*$,$% .'(% 0*2*% #-2,Y(*2#'-S% @(2#.#5#*L%

#-2,LL#Y,-5,%!'0*1S%HPI9HDE%JCIIINS%

CGS %%%>S% !S% b(#,0U*-S% <,3(,$,-2*2#'-% *-0% '32#U#_*2#'-% .'(% 0*2*% #-2,Y(*2#'-S% 6"?% 2",$#$F%

;-#R,($#21%'.%`*$"#-Y2'-F%JCIIIN%

Références

Documents relatifs

High-throughput sequencing techniques are increasingly used and allows to measure a large quantity of data at different levels of the living organism under study. As the cost of

(1) The configuration of source databases was completely independent, except for the Federation Ontology, which lists the URL of each endpoint and the concepts each imple- ments;

As we noted above, the reasoning rules to support ontology for the data in- tegration concept are based on the OPENMath formalism and the algebra of integrable data.. Let the

Today database systems are concerned with the management of health data, insurance data, scientic data, legislation data, military data, human communications data, emails and

The growth of biological resources and information led to the storage of large data, such as: physiological processes, gene patterns, disease-gene associations, clinical trials; in

Two major components constitute OnTAP: a Biological Data Integration Platform (BiDIP) and analysis modules includ- ing data pre-processing. There are four sets of analysis

A data integration subsystem will provide other subsystems or external agents with uniform access interface to all of the system’s data sources. Requested information

[r]