A prospective study of the evolution of lamivudine resistance mutations in patients with chronic hepatitis B treated with lamivudine

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Submitted on 16 Mar 2007

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A prospective study of the evolution of lamivudine resistance mutations in patients with chronic hepatitis B

treated with lamivudine

Fabien Zoulim, Thierry Poynard, Françoise Degos, Alain Slama, Abdelkhader Al Hasnaoui, Patrick Blin, Florence Mercier, Paul Deny, Paul Landais, Parviz

Parvaz, et al.

To cite this version:

Fabien Zoulim, Thierry Poynard, Françoise Degos, Alain Slama, Abdelkhader Al Hasnaoui, et al.. A prospective study of the evolution of lamivudine resistance mutations in patients with chronic hepatitis B treated with lamivudine. Journal of Viral Hepatitis, Wiley-Blackwell, 2006, 13 (4), pp.278-288.

�inserm-00135954�

Number of subjects

0 50 100 150 200 250 300

0 6 12 18 24

Treatment duration (months)

0% 6%

22%

37% 41%

Fig1 Panel A

Fig1 Panel B

Number of subjects Number of subjects

L180M L180M

0 0 5 5 10 10 15 15 20 20 25 25 30 30

6 6 12 12 18 18 24 24

L180M alone L180M alone

L180M with M204x L180M with M204x

M204I M204I

M204I alone M204I alone

M204I with L180M M204I with L180M

15 15 20 20 25 25 30 30

M204V M204V

15 15 20 20 25 25

30 30 M204V alone M204V alone

M204V with L180M

M204V with L180M

0 10 20 30 40 50 60 70 80 90 100

0 6 12 18 24

Subjects with detectable viral DNA (%) *** ***

Fig 2, Panel A

* *

20 30 40 50 60 70 80 90 100

seroconversion (%)

Fig 2, Panel B

*** **

**

0 6 12 18 24

Subjects with elevated transaminases (%)

0 5 10 15 20 25 30 35 40 45 50

Fig 2, Panel C