• Aucun résultat trouvé

Yes and PI3K bind CD95 to signal invasion of glioblastoma.

N/A
N/A
Protected

Academic year: 2021

Partager "Yes and PI3K bind CD95 to signal invasion of glioblastoma."

Copied!
1
0
0

Texte intégral

(1)

Yes and PI3K Bind CD95

to Signal Invasion of Glioblastoma

Susanne Kleber,1,10 Ignacio Sancho-Martinez,1,10 Benedict Wiestler,1,10 Alexandra Beisel,1 Christian Gieffers,6

Oliver Hill,6 Meinolf Thiemann,6 Wolf Mueller,5 Jaromir Sykora,8 Andreas Kuhn,1 Nina Schreglmann,1 Elisabeth Letellier,1 Cecilia Zuliani,1 Stefan Klussmann,1 Marcin Teodorczyk,1 Hermann-Josef Gro¨ ne,2 Tom M. Ganten,8 Holger Su¨ ltmann,3 Jochen Tu¨ ttenberg,9 Andreas von Deimling,5 Anne Regnier-Vigouroux,4

Christel Herold-Mende,7 and Ana Martin-Villalba1,*

1Molecular Neurobiology Group

2Division of Cellular and Molecular Pathology 3Division of Molecular Genome Analysis 4INSERM U701

5KKE Neuropathology

German Cancer Research Center (DKFZ), INF 581, 69120 Heidelberg, Germany

6Apogenix GmbH, Heidelberg, 69120 Heidelberg, Germany 7Department of Neurosurgery

8Department of Internal Medicine

University of Heidelberg, INF 400, 69120 Heidelberg, Germany

9Department of Neurosurgery, University of Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany 10These authors contributed equally to this work.

*Correspondence: a.martin-villalba@dkfz.de DOI 10.1016/j.ccr.2008.02.003

SUMMARY

Invasion of surrounding brain tissue by isolated tumor cells represents one of the main obstacles to a curative therapy of glioblastoma multiforme. Here we unravel a

Références

Documents relatifs

When exposed to the two forms of CD95L, cleaved and membrane-bound, activated T lymphocytes, target cells (infected or transformed cells) or bystander cells undergo an Orai1-driven

However, while a human CD95 mutant deleted of the previously described PLAD domain (amino acids 1 to 66) fails to interact with its wild-type counterpart and trigger autonomous

Notably, when caspase-8 activity is inhibited or its expression is extinguished, DISC is unable to trigger the apoptotic signaling pathway, but TNFR1 or CD95 stimulation

Amsterdam is a very active mud volcano (recently extruded mud flows and evidence of high methane emission; see Chapter 3, and above), so the finding of gas hydrates there refutes

Here, we showed that, in rodents and humans, injury to the spinal cord triggered surface expression of CD95 ligand (CD95L, FasL) on peripheral blood myeloid cells.. CD95L

Here we show that in neural stem cells, stimulation of the "death receptor" CD95 does not trigger apoptosis but unexpectedly leads to increased stem cell survival and

For each predefined threshold-value of the ratio, sensitivity and specificity regarding a definite diagnosis of MF or BLC were calculated, taking into account that: a true

Les souris ainsi greffées ont été trai- tées par des doses non mortelles de l’anticorps anti-Fas Jo2 pour induire la lyse des hépatocytes résidents très sensibles à