HAL Id: pasteur-02014338
https://hal-riip.archives-ouvertes.fr/pasteur-02014338
Submitted on 11 Feb 2019
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Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 Phenotype
Amira Refai, Sami Gritli, Mohamed-Ridha Barbouche, Makram Essafi
To cite this version:
Amira Refai, Sami Gritli, Mohamed-Ridha Barbouche, Makram Essafi. Mycobacterium tuberculosis
Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phe-
notype and Subsequently Switches It to the Anti-inflammatory M2 Phenotype. Frontiers in Cellular
and Infection Microbiology, Frontiers, 2018, 8, �10.3389/fcimb.2018.00327�. �pasteur-02014338�
Edited by:
Fabiana Bigi, Instituto Nacional de Tecnología Agropecuaria (INTA), Argentina Reviewed by:
Pablo Schierloh, Academia Nacional de Medicina, Argentina Avinash Sonawane, KIIT University, India
*Correspondence:
Makram Essafi makram.essafi@pasteur.tn
Specialty section:
This article was submitted to Molecular Bacterial Pathogenesis, a section of the journal Frontiers in Cellular and Infection Microbiology
Received: 10 May 2018 Accepted: 27 August 2018 Published: 18 September 2018
Citation:
Refai A, Gritli S, Barbouche M-R and Essafi M (2018) Mycobacterium tuberculosis Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 Phenotype.
Front. Cell. Infect. Microbiol. 8:327.
doi: 10.3389/fcimb.2018.00327
Mycobacterium tuberculosis Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the
Pro-inflammatory M1 Phenotype and Subsequently Switches It to the
Anti-inflammatory M2 Phenotype
Amira Refai
1, Sami Gritli
1,2, Mohamed-Ridha Barbouche
1and Makram Essafi
1*
1