Schematic time scale of experiments. A: Rotarod. B: Muscle biopsy (MBx) and electrophysiology. rpm = rotations per minute
Day 1 Day 2 Day 3 Day 4 Day 5
Training phase 120 s at 5 rpm Constant mode (5 repetitions)
Test phase Max :32 rpm
Acceleration mode (6 repetitions) (A) Rotarod test
Week 7 Week 15 Week 23
MBx -8-9th week
(B) MBx and electrophysiology
MBx -16th week
MBx – 24th Week
Supplementary Figure 1
Week 37
Electrophysiology Week 9, 16 & 23