GENERAL INFORMATION TUESDAY POSTERS
IMAGING MS: DISEASE MARKERS 313 - 344
TP 313 New Insights into the Microenvironment of Cancerous Tissue by Combined Mass Spectrometry, Microscopy and Multivariate Analysis; Tina Angerer1; John Stephen Fletcher1; 1University of Gothenburg, Gothenburg, Sweden TP 314 Typing of Colon and Lung Adenocarcinoma using
High-throughput Imaging Mass Spectrometry; Rita Casadonte1; Mark Kriegsmann2; Rémi Longuespée1; Petra Wandernoth1, 3; Cristina Mohanu3; Tiemo Katzenberger4; Daniela Aust5; Gustavo Baretton5; Jörg Kriegsmann1,
3, 6; 1Proteopath GmbH, Trier, Germany; 2University of Heidelberg, Heidelberg, Germany; 3Molekularpathologie Trier, Trier, Germany; 4Department of Pathology, Hospital Aschaffenburg, Aschaffenburg, Germany; 5University of Dresden, Dresden, Germany; 6Center for Histology, Cytology and Molecular Diagnostics Trier, Trier, Germany TP 315 Desorption Electrospray Ionisation Imaging towards
Enhanced Breast Cancer Diagnosis; Dipa Gurung1; James McKenzie1; Francesca Rosini1; Luisa Doria1; Anna Mroz1; Rathi Ramakrishnan1; Edward R St John1; Jeremy K Nicholson1; Zoltan Takats1; 1Imperial College London, South Kensington Campus London, United Kingdom
TP 316 MALDI-MS Imaging of Lipid Changes after PI3-K Inhibition in Colorectal Cancer Liver Metastases; Fiona Henderson1; Irma Berrueta Razo2; Nicholas Lockyer2; Omar Belgacem3; Kaye J Williams4; Adam McMahon1;
1Wolfson Molecular Imaging Centre, University of Manchester, Manchester, England; 2Manchester Institute of Biotechnology, University of Manchester, Manchester, England; 3Shimadzu, Manchester, England; 4Stopford Building, University of Manchester, Manchester, England TP 317 Multimodal imaging of lipids in a Zebrafish Melanoma
Model by PET and DESI-MS; Emrys Jones1; Fiona Henderson2; Anthony Midey3; Adam Hurlstone2; Duncan Foster2; Hannah Johnston2; Kaye Williams2; Adam W McMahon2; Emmanuelle Claude1; 1Waters Corporation, Wilmslow, UK; 2Wolfson Molecular Imaging Centre, Manchester, UK; 3Waters Corporation, Beverly, Massachusetts
TP 318 Comparative Mapping of PSA and N-glycan
Distributions in FFPE Prostate Cancer Tissues using MALDI-FTICR and Rapid MALDI-TOF Mass Spectrometry Imaging; Richard R Drake1; Peggi M Angel1; Hendrik Jan Kobarg2; Shannon Cornett3; 1Medical University of South Carolina, Charleston, SC; 2SCiLS GmbH, Bremen, Germany; 3Bruker Daltonic, Billerica, MA
TP 319 Imaging Mass Spectrometry Approach for the Diagnosis of Carcinoma of the Cervix; Rita Casadonte1; Rémi Longuespée1; Mark Kriegsmann2; Michael Becker3; Sören-Oliver Deininger3; Mike Otto1; Jörg Kriegsmann1,
4; 1Proteopath GmbH, Trier, Germany; 2University of Heidelberg, Heidelberg, Germany; 3Bruker Daltonik GmbH, Bremen, Germany; 4Centre for Histology, Cytology and Molecular Diagnostics, Trier, Germany
GENERAL INFORMATION TUESDAY POSTERS
TP 320 MALDI Imaging a Tool for Clinical Diagnostic – Classification of Prostate Cancer Subgroups; Birte Beine1; Tobias Boskamp2; Dimo Dietrich3; Hendrik Jan Kobarg4; Konrad Steinestel5; Piotr Widlak6; Barbara Sitek7; Helmut Erich Meyer8; Corinna Henkel8; 1ISAS e.V., Dortmund, NRW; 2Center for Industrial Mathematics, University of Bremen, Bremen, Germany; 3Institute of Pathology, University Hospital Bonn (AöR), Bonn, Germany;
4SCiLS GmbH, Bremen, Germany; 5 Gerhard-Domagk-Institute of Pathology, University Hospital Münster (UKM), Münster, Germany; 6Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska - Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland; 7Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany; 8ISAS - e.V., Dortmund, Germany
TP 321 Molecular Markers of Serous Ovarian Cancer Aggressiveness and Surgical Outcome by Ambient Ionization Mass Spectrometry Imaging; Marta Sans Escofet1; Kshipra Gharpure2; Jialing Zhang1; Jinsong Liu2; Anil K. Sood2; Livia S. Eberlin1; 1University of Texas at Austin, Austin, TX; 2the University of Texas M.D Anderson Cancer Center, Houston, TX
TP 322 Linking Lipid Metabolism, Hypoxia, Radiation Therapy and Metastasis using DESI Imaging Mass Spectrometry;
Erik J. Soderblom1; Kathleen Ashcraft2; Matt W. Foster3; Emmanuelle Claude4; Emrys A Jones4; James Langridge4; M. Arthur Moseley3; Mark Dewhirst2; 1Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham , NC; 2Radiation Oncology, Duke University Medical Center, Durham, NC; 3Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC; 4Health Sciences, Waters Corp, Manchester, UK
TP 323 Elemental Analysis and Imaging of Stroke-affected Brain Tissues by Utilizing Laser Ablation-inductively Coupled Plasma-Mass Spectrometry: Diagnostic Study;
Khalid A. Al-Saad1; Mohamed H Ali2; MD Fazle Rakib1; Eman M Fayyad1; Rick Dijkhuizen3; Geralda V Tilborg3;
1Qatar University, Doha, Doha; 2Qatar Biomedical Research Institute, Doha, Qatar; 3University Medical Center Utrecht, Utrecht, Netherlands
TP 324 Molecular Signature Discovery of Human Chronic Traumatic Encephalopathy Tissues using Mass Spectrometry Imaging; Bo Yan1; Dharmendra B.
Goswami1; Deborah R Leon1; Mark E McComb1; Ann C.
McKee1, 2; Catherine E Costello1; 1Boston University School of Medicine, Boston, MA; 2United States Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA TP 325 MALDI Imaging of Neuronal Plasticity: Analysing Fine
Adaptations with Large Effects; Jakob Meier-Credo1; Michael Becker2; Alice Ly2; Shahar Or1; Irina Epstein1; Thomas Hagedorn2; Tamas Dalmay1; Johannes J Letzkus1; Erin Schuman1; Julian Langer1; 1Max-Planck-Institute for Brain Research, Frankfurt Am Main, Germany; 2Bruker Daltonik GmbH, Bremen, Germany
TP 326 Nanoparticle Matrix Implantation Mass Spectrometry Imaging Discovers and Quantifies Lipid Biomarkers of Traumatic Brain Injury and Tracks Therapeutic Response; Aurelie Roux1; Ludovic Muller2; Shelley N Jackson2; Jeremy Post; Katherine Baldwin3; Barry Hoffer4; Carey Balaban5; Damon Barbacci6; Albert J Schultz7; Shawn Gouty8; Brian M Cox8; Amina S Woods9; 1All Children’s Hospital Johns Hopkins Medicine, Saint Petersburg, FL;
2NIH/NIDA-IRP, Baltimore, MD; 3Philadelphia College of Osteopathic Medicine, Philadelphia, PA; 4University Hospitals of Cleveland, Cleveland, OH; 5University of Pittsburgh, Pittsburgh, PA; 6Ionwerks, Gaithersburg, MD;
7Ionwerks Inc, Houston, TX; 8Uniformed Services University, Bethesda, MD; 9NIDA-IRP, NIH Baltimore, MD
TP 327 MALDI Mass Spectrometry Imaging in Alzheimer’s disease mouse model Het CRND8 (+/-);Lyna SellamI1; Marcia Roy2; Matthew E Openshaw1; Luis Mancera1; Omar Belgacem1; 1Shimadzu, Kratos Manchester, United Kingdom; 2University of Edinburgh, Edinburgh, UK TP 328 Simultaneous MALDI MS Imaging and Quantitation
of Multiple Neurotransmitters In Parkinson’s Disease Models; Elva Fridjonsdottir1; Mohammadreza Shariatgorji1; Anna Nilsson1; Patrik Källback1; Xiaoqun Zhang2; Per Svenningsson2; Per E. Andren3; 1Uppsala University, Uppsala, Sweden; 2Karolinska Institutet, Stockholm, Sweden; 3Uppsala University, Uppsala, SE
TP 329 Detection of Ganglioside Lipid Species in the Brain of Mucopolysaccharidosis Type II Mouse by Imaging Mass Spectrometry; Martin Dufresne1; Daniel Guneysu1; Martin Marcinkiewicz2; Anthony Regina3; Michel Demeule3; Pierre Chaurand4; 1Université de Montréal, St-Hyacinthe, QC;
2Cytochem Inc., Montreal Quebec, Canada; 3Angiochem Inc., Montréal, QC, Canada; 4University of Montreal, Montreal, QC
TP 330 Studying the Sphingolipid Pathway into Co-morbidity of Depression and Alcoholism by MALDI Imaging FT-ICR Mass Spectrometry; Christian P Muller1; Matthias Witt2; Michael L Easterling3; Jens Fuchser2; Beckmann Janine2; Thomas Stockl1; Eva Sprenger1; Jens Tiesel1; Sabine E Huber1; Davide Amato1; Erich Gulbins4; Martin Reichel1; Johanes Kornhuber1; 1Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany; 2Bruker Daltonik GmbH, Bremen, Germany; 3Bruker Daltonics, Billerica, MA;
4Department of Molecular Biology, University of Duisburg-Essen, Duisburg-Essen, Germany
TP 331 Molecular Mapping of Gangliosides and Related Lipids using Mass Spectrometry Imaging with Ion Mobility Separation; Bindesh Shrestha1; Hernando Olivos2; Khaja Muneeruddin3; Miguel Sena-Esteves3; Scott A Shaffer3;
1Waters Corp., Beverly, MA; 2Waters Corporation, Beverly, MA; 3University of Massachusetts Medical School, Worcester, MA
TP 332 Evaluating the Viability of Kidney Transplants using High-speed MALDI-Imaging; Shane R Ellis1; Tim C van Smaalen2; Nadine E Mascini1, 3; Berta Cillero-Pastor1; Tiffany Porta1; Benjamin Balluff1; Carine J Peutz-Koostra2; L.W.E van Heurn4; Ron M A Heeren1; 1M4I, Maastricht University Maastricht, the Netherlands; 2Maastricht UMC+, Maastricht, Netherlands; 3FOM Institute AMOLF, Amsterdam,
Netherlands; 4University of Amsterdam, Amsterdam, The Netherlands
TP 333 Proteomic Mass Imaging of Kidney from Type 2 Diabetes (T2D) Rat Model; Hirata Chie1; Kuzuhara Yuki1; Iwasaki Noriyuki2; Kudo Toshiji2; Nirasawa Takashi2; Masuyama Kei3; Kakuda Nobuto1; Wakazono Hiroshi3; Yanagi Hiroyuki3; Masaya Ikegawa4; 1Doshisha University, Kyotanabe, Japan; 2Bruker Daltonics K.K., Kanagawa, Japan; 3Ono Pharmaceutical Co., Ltd., Fukui, Japan;
4Doshisha University, Kyotanabe City
TP 334 Differentiating Macrophages in Atherosclerotic Plaques using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging; Pegah Khamehgir-Silz1; Florian Schnitter2; Andreas H. Wagner2; Sabine Schulz1; Markus Hecker2; Bernhard Spengler1; 1Justus Liebig University, Giessen, Germany; 2Ruprecht-Karls-University, Heidelberg, Germany
TP 335 What Can We Learn from the Na+/K+ Ratio in Imaging Mass Spectrometry Experiments?; Roberto Fernandez1; Jone garate1; Sergio Lage1; Silvia Teres2; Pau Gonzalez3; Monica Higuera4; Alfredo Maqueda3; Joan Bestard-Escalas5; Daniel H Lopez5; Francisca guardiola-serrano4; Pablo V Escribá4; Javier Rodriguez3; Gwendolyn Barceló-Coblijn5; Jose A. Fernandez6; 1Universidad del Pais Vasco, Leioa,
TUESDAY POSTERS
Spain; 2Institut européen de chimie et biologie, Pessac, France; 3National Hospital for Paraplegics, Toledo, Spain;
4University of the Balearic Islands, Palma Balearic Islands, Spain; 5Institut d’Investigació Sanitària de Palma, Palma Balearic Islands, Spain; 6Universidad del Pais Vasco, leioa, Spain
TP 336 Analysis of Retinal Degeneration in a Leber Congenital Amaurosis Mouse Model Using High Spatial Resolution MALDI-Imaging Mass Spectrometry; David M. Anderson1; Zsolt Ablonczy2; Yiannis Koutalos2; Nico Verbeeck3; Raf Van De Plas1, 3; Jeffrey Spraggins1; Rosalie K. Crouch2; Richard M Caprioli1; Kevin L. Schey1; 1Vanderbilt University MSRC, Nashville, TN; 2Department of Ophthalmology, Storm Eye Institute, Medical University of South, Charleston, SC; 3Delft Center for Systems and Control (DCSC), Delft University of Technology, Delft, Netherlands
TP 337 Molecular Target Validation in Human Atherosclerosis Based on Mass Spectrometry Imaging and
ImmunHistoChemistry Evaluation; Jonathan Stauber1; Gregory Hamm1; Sylvia Aldi2; Juliette Masure1; Kim Holmstrom3; Serife Arda4; Danielle Van Keulen5, 6; David Bonnel1; Ivana Bobeldijk-Pastorova5; Dennie Tempel6; Boye S Nielsen3; Michael Gudo4; Jan NH Lindeman7; Ulf Hedin2; Alain van Gool5; Eva Hurt Camejo8; 1ImaBiotech, MS Imaging Dept. Loos, France; 2Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; 3Bioneer, Hoersholm, Denmark; 4Morphisto, Frankfurt Am Main, Germany; 5TNO, Metabolic Health Research Leiden, The Netherland; 6CardioGenx, Rotterdam, The Netherlands; 7Leiden University Medical Centre, Leiden, The Netherlands; 8AstraZeneca R&D, Gothenburg, Sweden TP 338 Simultaneous Detection of N-glycans and Peptides from
a Single FFPE Tissue Section by MALDI FT-ICR Imaging Mass Spectrometry; Peggi Angel1; Rita Casadonte2; Jörg Kriegsmann2; Richard Drake3; 1Medical University of South Carolina, Charleston, SC; 2Proteopath GmbH, Trier, Germany; 3Medical Univ of S Carolina, Charleston, SC TP 339 The Effect of Oxygen on the Lipid Composition of
Human Chondrocytes using MALDI Imaging; Brenda Bakker1; Gert Eijkel2; Ron Heeren2; Marcel Karperien1; Janine Post1; Berta Cillero-Pastor2; 1Developmental BioEngineering, University of Twente, Enschede, The Netherlands; 2The Maastricht Multimodal Molecular Imaging Institute (M4I), Maastricht University, Maastricht, The Netherlands
TP 340 Metabolite Profiling of Intestinal Microbiota by Mass Spectrometry Imaging for Biological Understanding of Gastrointestinal Disease; Gregory Hamm1; Juliette Masure1; Sylvain Normand2; David Bonnel1; Mathias Chamaillard2; Jonathan Stauber1; 1ImaBiotech, MS Imaging Dept. Loos, France; 2Center of Infection and Immunity of Lille (CIIL), Team 7, Inserm U1019, CNRS UMR8204, Lille, France
TP 341 Differential Human Pancreatic Lipid and Protein Distributions in Normal and Type 1 Diabetes Revealed by Tissue Imaging Mass Spectrometry; Boone M Prentice1; Rachana Haliyur1; Nathaniel J Hart1; Audra M Judd1; Radhika Aramandla1; Marcela Brissova1; Jeffrey M Spraggins1; Jeremy L Norris1; Alvin C Powers1; Richard M Caprioli1; 1Vanderbilt University, Nashville, TN
TP 342 Lipid and Metabolite Distribution in Healthy and Diseased Brain Tissue using DESI and High Resolution Mass Spectrometry; Joseph H Kennedy1; Jeff Patrick1; Mariam ElNaggar1; Justin M Wiseman1; 1Prosolia, Inc.
Indianapolis, IN
TP 343 Imaging Mass Spectrometry for the Pathological Studies of Cardiac Allografts; Terada Megumi1; Iwasaki Noriyuki2; Kudo Toshiji2; Nirasawa Takashi2; Bruneval
Prtrick3; Ishibashi-Ueda Hatsue4; Masaya Ikegawa5;
1Doshisha University, Graduate School of Brain Scie Kyoto, Japan; 2Bruker Daltonics K.K., Kanagawa, Japan; 3Georges Pompidou European Hospital, Paris, France; 4National Cerebral and Cardiovascular Center, Osaka, Japan;
5Doshisha University, Kyotanabe City
TP 344 High Spatial Resolution Lipid Imaging Offers Promising Perspectives in Sustaining Diagnosis of Human Lymphoma; Yousef El Aalamat1; Arndt Asperger2; Xian Mao1; Wim Waelput3; Thomas Tousseyn4; Bart De Moor1; Etienne Waelkens5; 1ESAT-STADIUS / iMinds Medical IT, KU Leuven, Leuven, Belgium; 2shared first author, Bruker Daltonik GmbH,, Bremen, Germany; 3Dept. of Pathology, UZ-Brussel,, Brussel, Belgium; 4Dept. Imaging and Pathology, KU Leuven,, Leuven,, Belgium; 5Dept. Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium IMAGING MS: PHARMACEUTICAL APPLICATIONS
345 - 363
TP 345 Towards Absolute Quantitative MALDI MS Imaging of Drugs; Patrik Kallback1; Theodosia Vallianatou2; Anna Nilsson2; Mohammadreza Shariatgorji2; Per E Andren2;
1Uppsala University, Uppsala, Uppsala; 2Uppsala University, Uppsala, Sweden
TP 346 Derivatization Strategies for the Quantitation of Triamcinolone Acetonide in Cartilage by using Imaging Mass Spectrometry; Florian Barré1; Bryn Flinders1; Joao Garcia2; Laura Creemers2; Ron M A Heeren1; Berta Cillero-Pastor1; 1M4I Institute - Maastricht University, Maastricht, The Netherlands; 2Utrecht University, Utrecht, The Netherlands
TP 347 3D MALDI Mass Spectrometry Imaging to Empower Drug Distrubution And Quantitation Studies in Solid Tumors; Silvia Giordano1; Lavinia Morosi1; Pietro Veglianese1; Simonetta Andrea Licandro1; Roberta Frapolli1; Massimo Zucchetti1; Maurizio D’Incalci1; Enrico Davoli1;
1IRCCS Istituto Mario Negri, Milano, Italy
TP 348 Study of the Blood Brain Barrier Permeability using a Multimodal Imaging Approach; David Calligaris1; Fa-Ke Lu1; Armen Changelian1; Isaiah Norton1; Brett L Carlson2; Jeffrey Agar3; William F Elmquist4; Daniel MA2; Jann N Sarkaria2; Nathalie YR Agar1; 1Department of Neurosurgery, Brigham and Women’s Hospital - Harvard Medical School, Boston, MA; 2Mayo Clinic, Rochester, MN; 3Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA; 4Department of Pharmaceutics, University of Minnesota, Minneapolis, MN
TP 349 Comparison of LESA-MS to MALDI-MS for Mouse Whole Body Tissue Profiling: Diclofenac and Major Metabolites; Walter Korfmacher1; Gargey Yagnik2; Yongyi Luo3; Stacy Ho2; Liduo Shen3; Terry Wilper4; Karen Norton4; Eric Solon5; Hanlan Liu2; Sara Savage4; Thomas O’Shea2; 1Genzyme, Waltham, MA; 2Genzyme, a Sanofi company Waltham, MA; 3Sanofi, Waltham, MA; 4Genzyme, Framingham, MA; 5QPS, Newark, DE
TP 350 Matrix Assisted Laser Desorption/Ionisation Mass Spectrometry Imaging of Therapeutic Oligonucleotides:
Application to Antisense Therapy; C. Logan Mackay1; John G Swales2; Richard J A Goodwin2; 1SIRCAMS, Edinburgh, UK; 2AstraZeneca, Cambridge, UK TP 351 Microinjection and High-throughput Alignment of
Cellular Spheroids for MALDI Mass Spectrometry Imaging Analysis; Jillian Johnson1; Fengfei Ma1; Weiyuan John Kao1; Lingjun Li1; 1University of Wisconsin-Madison, Madison, WI
TP 352 Applications of Single-Probe Device for Ambient Mass Spectrometry Imaging Analysis: Human Corneas and 3D Artificial Tumors; Xiang Tian1; Wei Rao1; Ning Pan1; Haiqing Yu1; Dimitrios Karamichos2; Zhibo Yang1; 1University
GENERAL INFORMATION TUESDAY POSTERS
of Oklahoma, Dept. of Chem & Biochem Norman, OK;
2University of Oklahoma Health Science Center, OKC, OK TP 353 Application of Imaging Mass Spectrometry to Assess Ocular Drug Transit; Kerri Grove1; Viral Kansara2; Melissa Prentiss2; Debby Long2; Muneto Mogi2; Sean Kim2; Patrick Rudewicz1; 1Novartis Institutes for BioMedical Research, Emeryville, CA; 2Translational Clinical Oncology, Novartis Institutes for Biomedical Research, Cambridge, MA TP 354 MALDI-FTICR Imaging of the Distribution of
Teriflunomide in CNS Tissues in an Experimental Model of Multiple Sclerosis; Ignacy Rzagalinski1; Carola Meier1; Nadine Hainz1; Thomas Tschernig1; Dietrich Volmer1;
1Saarland University, Saarbrücken, Germany
TP 355 Multimodal Mass Spectrometry Imaging for Detection and Early Prediction of Drug Induced Phospholipidosis;
Richard Goodwin1; Anna Nilsson2; Jennifer Barnes1; Julia Sampson1; Hui Zhang3; John G Swales1; Nicole strittmatter4; Alan Race5; Rory Steven5; Logan C Mackay6; Josephine Bunch5; Per E Andren2; 1AstraZeneca, Cambridge, UK;
2Uppsala University, Uppsala, Sweden; 3AstraZeneca R&D, Mölndal, Sweden; 4AstraZeneca, Macclesfield, Select State;
5National Physical Laboratory, Teddington, United Kingdom;
6University of Edinburgh, Edinburgh, United Kingdom TP 356 The Evaluation of Erythroblast Dynamics in Mice Bone Marrows by MALDI FTICR-MS Imaging which Identifies 57Fe-labeled Heme Isotopic Fine Structure;
Makoto Kihara1; Yukari Matsuo-Tezuka2; Keigo Yorozu2; Mitsue Kurasawa2; Hideyuki Yasuno2; Yasushi Shimonaka2;
1Chugai Pharmaceutical Co., Ltd, Kamakura, Japan;
2Chugai Pharmaceutical Co., Ltd Kamakura, Japan TP 357 Large Scale, Multi-Instrument MALDI-MSI Study into
Lipidosis in Inhalation Dosed Rats; Rory Thomas Steven1; Alan Race1; Aateka Patel2; Lea Ann Dailey2; Josephine Bunch1, 3; 1National Physical Laboratory, Teddington, UK; 2King’s College London, London, UK;
3University of Nottingham, Nottingham, UK
TP 358 MALDI Imaging Mass Spectrometry of Platinum-Based Drugs in Multicellular Tumor Spheroids (MCTS) using Derivatization with Diethyldithiocarbamate (DDTC); Xin Liu1; Amanda B Hummon1; 1University of Notre Dame, Notre Dame, Indiana
TP 359 Visualization of Small Molecule and Nanoparticle Anticancer Agents in Tissue and Tumor Sections using IR-MALDESI Mass Spectrometry Imaging; Mark Bokhart1; Allison Schorzman2; Andrew Lucas2; Michael Berens3; Harshil Dhruv3; William Zamboni2; David C Muddiman1;
1North Carolina State University, Raleigh, NC; 2UNC - Chapel Hill, Chapel Hill, NC; 3Translational Genomics Research Institute, Phoenix, AZ
TP 360 Tissue Distribution of Compound X and its Metabolites in Jck Mouse Polycystic Kidneys using Mass
Spectrometry Imaging (MSI); Hanlan Liu1; Cristina Silvescu1; Mandy Cromwell2; Kelly Keefe2; Lindsay Quigley2; Sirimas Sudsakorn1; Sarah Nsereko1; Yang Guo1; Laurie Smith3; Thomas Natoli3; Dinesh Bangari4; Gregory Hamm5; Aurore Tomezyk5; Raphael Legouffe5; David Bonnel5; Jonathan Stauberand5; Thomas O’Shea1; 1Drug Metabolism and Pharmacokinetics, Sanofi, Waltham, MA; 2Rare Disease Pharmacology, Sanofi, Waltham, MA; 3Rare Renal Disease Research, Sanofi,, Framingham, MA; 4Pathology, Sanofi, Framingham, MA; 5ImaBiotech, MS Imaging Dept.
Loos, France
TP 361 Visualizing Anti-Retroviral Distribution in Sheep and Human Vaginal Tissue by Imaging Mass Spectrometry;
Michelle Reyzer1; Mark Marzinke2; Trevelyn Olive3; Richard Pyles3; Kathleen L Vincent3; Manjula Gunawardana4; John Moss4; Marc M. Baum4; Richard M Caprioli1; 1Vanderbilt University, Nashville, TN; 2Johns Hopkins University, Baltimore, MD; 3University of Texas Medical Branch at
Galveston, Galveston, TX; 4Oak Crest Institute of Science, Monrovia, CA
TP 362 MALDI IMS in Drug Development: Shedding New Light on Toxicology; M. Reid Groseclose1; Stephen Castellino1;
1GlaxoSmithKline, Upper Merion, PA
TP 363 Complementary Elemental And Molecular Mass Spectrometry Imaging to Investigate 5-aminolevulinic Acid, Protoporphyrin IX and Heme Distribution in Human Brain Tumor; Sabrina Kröger1; Ann-Christin Niehoff1; Uwe Karst1; 1University of Münster, Institute of Inorganic and Analytical Chemistry, Münster
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