[PDF] Top 20 Which incretin-based therapy for type 2 diabetes?

... with type 2 diabetes and a high cardiovascular risk ...of incretin-based therapies for the management of type 2 ... Voir le document complet

... Ca 2+ entry and cytoplasmic free Ca 2+ concentration rise in beta cells, leading to activation of the exocytotic machinery and glucose-dependent insulin ...target for insulinotropic ...used ... Voir le document complet

... that incretin-based therapies are rather new approaches in the management of T2DM [15] , their PK characteristics in patients with different degrees of HI have been more extensively investigated and thereby ... Voir le document complet

... of diabetes was based on 2 OGTT as recommended by the Expert Committee of the American Diabetes Association [12], acarbose treatment resulted in a ...of diabetes (p = ...placebo ... Voir le document complet

... metformin therapy had lower joint replacement surgery rates than those without metformin (adjusted HR = ...bined therapy with ...tion based case-control study was performed in UK using the Clinical ... Voir le document complet

... first-line therapy for most individuals. [2-4] Second-line agents are diverse and increasingly ...cotransporter type 2 (SGLT2) inhibitors (gliflozins), [6] glucagon-like peptide-1 ... Voir le document complet

... option for patients with advanced T2D, particularly if their glycaemic control is inadequate with other oral glucose-lowering ...glucotoxicity, which indirectly results in an improvement of beta-cell ... Voir le document complet

... of type 2 diabetes, which has a long subclinical ...are based on data from observational studies and, as such, preclude direct causal ... Voir le document complet

... and diabetes therapies, and included questions on feelings, perceptions, and fears of insulin ...possible for other questions. For questions relating to feelings, respondents were asked to rate their ... Voir le document complet

... Diabetes & Metabolism 40 (2014) S1-S3 Type 2 diabetes is among the most important and preva- lent chronic diseases, and any novel therapy that is able to address chronic ... Voir le document complet

... risk for DKA was observed for SGLT2is as a class (MH-OR, ...in which an SGLT2i was listed among suspect or concomitant drugs in the US FDA Adverse Event Reporting ...higher for type 1 ... Voir le document complet

... evidence for a predominantly lower bowel-mediated mechanism of metformin action at therapeutic doses ...discussion. For instance, the 95% CI for the reduction in FPG with the three doses of metformin ... Voir le document complet

... endpoints, which, however, may differ across RCTs ( Table 1 – 4 ...marker, for instance reduction in albuminuria, but not clinical events of true relevance to T2DM patients, for instance need ... Voir le document complet

... Photodynamic therapy PDT became acknowledged as an innovative oncological treatment in the 1970’s by Dougherty et ...the type and dose of PS used, the light dose and the oxygen concentration in the tissue ... Voir le document complet

... atorvastatin for several years who had recently (6 months ago) started taking ...drug therapy could be identified in this clinical case), which can but does not necessarily predispose to acute kidney ... Voir le document complet

... regression, which is based here on logistic regression, allows automatic feature selection, but does not handle well correlated variables, while elastic nets are able to deal with ... Voir le document complet

... metformin therapy (+50%; P = ...accounted for by a pure pharmacological effect of metformin that did not persist when the drug was stopped (1) is in agreement with those experimental results ...of ... Voir le document complet

... you for forwarding the letter of the distinguished colleagues, Andre Scheen and Luc Van Gaal, and the opportunity to ...be based on available evidence in the form of published, full papers at the time they ... Voir le document complet

... treatment-resistant diabetes with so-called ‘Psychological Insulin Resistance’ ...and for patients to take, insulin despite insulin therapy becoming necessary because of PPDM with oral antidiabetic ... Voir le document complet

... Table 2 presents the results of the primary analysis for DPP-4 inhibitors and GLP-1 receptor ...ratios for cumulative durations of one year to two years and with more than two years since treatment ... Voir le document complet