[PDF] Top 20 Serotonin: a new hope in Alzheimer's disease?

... deficits in AD mouse models 3 . Today, plaques are often viewed as a way by which damaged cells try to diminish Ab toxicity; namely, plaques may be an amyloid ...is a promising strategy to slow AD ... Voir le document complet

... roles in brain development, and physiology during life and ...with a variety of molecular sensors and through the various functions they can fulfill, they are critically involved in maintaining the ... Voir le document complet

... Background: In Alzheimer’s disease (AD), cognitive decline is known to start a dozen years before the clinical diagnosis of dementia is ...decline, new tasks are needed. Specifically, ... Voir le document complet

... learning. In AD, implicit rehabilitation techniques would be more effective to train new skills than explicit or declarative learning methods (van Halteren-van Tilborg, ... Voir le document complet

... of serotonin receptors (5-HTR), some of them, such as the subtype 4 (5-HT 4 R), are of particular interest in improving memory performance and therefore, de- creasing memory deficits, such as those that ... Voir le document complet

... In a broader perspective, emerging evidence shows the involvement of the P2X7R- NLRP3 inflammasome pathway in the induction of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis, ... Voir le document complet

... min in their home cage, the mouse was placed again in the start arm of the maze with the three arms ...opened. In average, WT-GFP, 3xTg-GFP and 3xTg-SOCS3 mice traveled the same total distance during ... Voir le document complet

... is a rich source of information for a medical practitioner for analysis of the behavior and the sequence of tasks of the patient executing ...posed in a new and challenging ...on ... Voir le document complet

... neurons in coronal slices of wildtype mice expressing GFP in Pet1-positive neurons (Pet1-GFP ...mice). In-vivo, DRN neurons fire with a regular pattern varying from ...neurons in ... Voir le document complet

... of a household’s electrical consumption due to the increasing number of digital home devices and the increasing complexity of the underlying communication ...iting a home network’s power consumption is ... Voir le document complet

... For these two reasons, environmental and economical, it is essential to provide an effective means of reducing power consumption, which is also transparent for the user. To do so, we propose a technical solution ... Voir le document complet

... valve, in line with a previous ...used a two-step diagnostic approach using high quality non-portable equipment and qualified ...providing a diagnosis on site with no need for further testing ... Voir le document complet

... INTRODUCTION In any given year, nearly 40% of the population in European countries is affected, directly or indirectly, by mental illness (Insel and Sahakian, ...the disease may vary among ... Voir le document complet

... 0.001). A history of hypertension was significantly associated with worse performance on overall cognition (mean ...Participation in self- administered computerized cognitive testing in older men was ... Voir le document complet

... gene in the western world, characterized by a hexanucleotide expansion in its intronic ...assess a possible loss-of-function mechanism ...infiltration in the spleen and the lymph nodes, ... Voir le document complet

... concerned a small number of patients followed up over 1 year. A larger trial is thus required to determine whether the observed physiological changes ...outcomes. In such a larger randomized ... Voir le document complet

... lipoproteins in chronic kidney disease ...activity in CKD, an increased carbamylation and a massive production of advanced glycation end products (AGEs) and advanced lipoxidation end products ... Voir le document complet

... Bénédicte Oulès 1* , Dolores Del Prete 2,3 , Barbara Greco 2 , Xuexin Zhang 4 , Inger Lauritzen 3 , Mohamed Trebak 4 , Fabio Benfenati 2 , Frédéric Checler 3 , Mounia Chami 3 From Molecular Neurodegeneration: Basic ... Voir le document complet

... selected by their parents because clinics are not required to report the number and type of cases they perform. In Europe, where infertility treatments are paid for[r] ... Voir le document complet

... create a hydrophilic pore between the cytoplasm of the connected cells allowing the exchange of low molecular weight chemical mediators like ions (Ca2+, Na+, ...as a complete gap junction, therefore ... Voir le document complet