... Abstract: **Parameter** **estimation** **in** **non** **linear** **mixed** **effects** **models** requires a large number of evaluations of the model **to** ...consuming **to** evaluate it ...

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... data **from** clinical trials using **mixed** effect analysis has recently become widely ...the **parameter** **estimation**, including LAPLACE and Gaussian quadrature (GQ), are associated **with** certain ...

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... recent **estimation** algorithms, **SAEM**, **in** R, **to** obtain maximum likelihood ...alternative **to** linearisation-based **estimation** methods as implemented for instance **in** nlme and ...

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... exact **SAEM** **algorithm** could also be extended **to** this case but is out of the scope of this ...paper. **To** take into account the censored-data problem **with** NLMEM, Wu (7; 17) proposes MCEM ...

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... Abstract **Non**-**linear** **mixed**-**effects** **models** (NLMEMs) are used **to** improve information gather- ing **from** longitudinal studies and applied **to** treatment evaluation ...

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... simulation **in** lini
al drug development is now well ...data, **with** ea
h subje
t providing several measurements throughout the ...staple **in** parti
ular of pharma
okineti (PK) and pharma
odynami (PD) ...

3

... Keywords. **Mixed** **models**, Stochastic Differential Equations, **SAEM** **algorithm**, Particle Filter, PMCMC, Stochastic volatility, Time-inhomogeneous SDE ...used **to** discriminate between the ...

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... variability **in** two-levels NLMEMs. They show that neglecting it resulted **in** biased estimates for the fixed ...The **parameter** **estimation** of NLMEMs is not trivial because the likelihood of NLMEMs ...

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... methods **to** fit evolution of CD4 and CD8 cells [4] or CD4 and 2 microglobuline ...EM **algorithm** **to** fit a bivariate **linear** random **effects** ...method **to** fit a bivariate ...

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... observed **in** images are related **to** the physical properties of the object, as illustrated on Figure 2 where each kind of tissues has a specific gray-level ...Due **to** acquisition noise, the image is ...

25

... everyone **in** the economy falls by ten ...jumps **from** state 1 **to** state 2 **with** intensity φ 1 and vice versa **with** intensity φ 2 ...difficulty: **in** contrast **to** the case without ...

20

... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou **non**, émanant des établissements d’enseignement et de recherche français ...

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... the **in**-domain couplings present **in** the PDEs and possibly attenuating the reflections on the controlled side (depending on the choice of a tun- ing ...these **in**-domain couplings, the new system can be ...

11

... the **estimation** of Markov (and semi-Markov) switching **linear** **mixed** **models** ...i.e. **models** that combine **linear** **mixed** **models** **with** individual- wise random ...

9

... of **in**- domain coupling and of the **ODE**), it can easily be seen that the exponential stability of the states u 1 (t, 0), v 2 (t, 1) is equivalent **to** the exponential stability of the whole ...Thus, ...

7

... everywhere **in** the PDE’s domain of definition D, using only temperature infor- mation **in** a small subdomain E ⊂ ...correspond **to** exact measurements of the ...model **parameter** of the EBMM using ...

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... case. **In** the context of Poisson **linear** inverse problems using sparsity-promoting regularization, a few recent algorithms have been ...Rachford) **to** solve the corresponding optimization problem. The ...

7

... performed **with** an extended version of the framework described **in** [12]: the main **algorithm** is the CMA-ES genetic **algorithm**, which asks at each iteration for the score of a high number of 3D ...

10

... dom **effects** and residuals, either **in** a nonparametric or **in** a parametric ...random **effects** into the classical resid- ual bootstrap plays therefore a very important role for bootstrapping ...

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... order **to** provide answers **to** study objectives, we introduce two contrast ...presented **in** Table 14. Extract of results are displayed **in** Tables 15 and ...corresponding **to** the number of ...

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