[PDF] Top 20 Histone deacetylase inhibitors and genomic instability.
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Histone deacetylase inhibitors and genomic instability.
... findings and the development of HDACIs as anticancer drugs, the number of studies reporting synergistic action between ionizing irradiation (IR) and HDACIs in cancer cell lines or animal pre-clinical models ... Voir le document complet
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Effect Of Inhibitors Of Histone Deacetylase On The Induction Of Cell Differentiation In Murine And Human Erythroleukemia Cell Lines
... b and Manfred Jung a Histone deacetylase (HDAC) inhibitors are a novel class of promising anti-cancer ...HDAC inhibitors to induce terminal cell differentiation in different cell types ... Voir le document complet
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Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1
... BRPF1 inhibitors Figure 1: Examples of previously reported BRPF bromodomain inhibitors HDACs are a group of enzymes responsible for the removal of acyl groups from acylated lysine residues in histones ... Voir le document complet
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Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
... CD15s and thus prevent suppression in tissues in ...mice and could confirm that nTreg cells expanded in that way could indeed prevent GVH disease, although not completely (Figure ...liver and the ... Voir le document complet
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Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors
... cells and enhances breast cancer cell metastasis ...cells and tissues of basal type [20] and that patients with higher SOX9 mRNA level had significantly shorter overall survival [42], thus supporting ... Voir le document complet
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Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection
... line and latently-infected J-Lat T-cell clones, we here demonstrated a strong synergistic activation of HIV-1 production by clinically used histone deacetylase inhibitors (HDACIs) combined ... Voir le document complet
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Prominent action of butyrate over beta-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule
... hours, and HMEC-1 for 6 hours. Histone acidic extraction, Western blotting and in vitro HDAC ...proteases inhibitors cocktail (Sigma-Aldrich, P2714) pH 8.0) and centrifugation (13,000 ... Voir le document complet
15
Erratum to: "CMTX1 patients' cells present genomic instability corrected by CamKII inhibitors"
... distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes ... Voir le document complet
2
Does interference between replication and transcription contribute to genomic instability in cancer cells?
... PBS, and fixed with 1% formaldehyde in PBS during 10 minutes at room ...γ-H2AX and DNA was hybridized on Affymetrix high-density tiling arrays (35 bp resolution) covering human chromosomes 1 and 6, ... Voir le document complet
15
Phosphorylation Of Histone Deacetylase 7 By Protein Kinase D Mediates T Cell Receptor-Induced Nur77 Expression And Apoptosis
... mocytes and T cell hybridomas is the orphan nuclear recep- tor Nur77, whose expression is rapidly induced during TCR-mediated ...Nur77 and induction of apoptosis occurs through TCR-mediated phosphorylation ... Voir le document complet
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Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity
... 3, and class IIb HDAC6, and to a lesser extent the class I HDAC8 (Table 1), suggesting that one or more of these isoforms repress CREB-dependent ...Egr1 and cFos in the brain (Guan et ...10 ... Voir le document complet
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Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions
... be histone modification readers, writers, and erasers (Fig. 2B and Table S1 ...2C and Table S1 ). For example, the bromodomain reader BRD4, the histone acetyltransferase writer ... Voir le document complet
7
Topoisomerase 1 suppresses replication stress and genomic instability by preventing interference between replication and transcription.
... 1 and 6 in shTop1 and shCtrl ...circles) and shTop1 (filled circles) cells mapped on the complete set of protein-coding genes on human chromosomes 1 and 6 with a sliding window of 1 ...genes ... Voir le document complet
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Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1.
... a histone methyltransferase inhibitor (HMTI) + an HDACI (Bouchat et al, 2012), an HMTI + an NF-jB inducer (Bouchat et al, 2012)] as a therapeutic perspective to decrease the pool of latent HIV-1 reservoirs in the ... Voir le document complet
22
Genomic Instability Signature of Palindromic Non-Coding Somatic Mutations in Bladder Cancer
... immunotherapy and the highly variable response to immune checkpoint inhibitors, as well as the significant economic cost of these agents, there is an urgent need for new biomarkers that could predict the ... Voir le document complet
16
Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory
... properties and functional requirements of chromatin within a given locus in the ...tissues, and disease status, 62 being able to target the unique combination of epigenetic regulatory features for a ... Voir le document complet
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A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.
... mitogen and stress activated kinase cascades leads not only to the activation of a variety of transcription factors but also to phosphorylation of HMG-14 (HMGN-1) and histone H3 known as the ... Voir le document complet
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CMTX1 patients' cells present genomic instability corrected by CamKII inhibitors
... removed and the cultures were grown and pas- saged 3 times before assays were ...protease and phosphatase ...denaturing and re- ducing conditions on 4-12% NuPAGE gels (Invitrogen) and ... Voir le document complet
7
Antidepressant Actions of Histone Deacetylase Inhibitors
... stress and the effect of intra-NAc MS-275 and systemic fluoxetine Gene name Social defeat MS-275 Fluoxetine Gene product function and potential role in psychiatric diseases Reference(s) cort 佧 佦 a 佦 ... Voir le document complet
11
Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors.
... Panobinostat and Bortezomib could be promising since proteasome inhibition affects the unfolded protein response pathway leading to increased HDAC mediated aggregosome formation(Hideshima et al, ...IB and ... Voir le document complet
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