[PDF] Top 20 DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes
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DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes
... To assess the potential role of RhoB in the cellular response to CPT, we compared survival of WT and RhoB-deficient RhoB⫺/⫺ E6-immortalized MEF cells after CPT treatment.. Cells were tre[r] ... Voir le document complet
306
en fr DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes Formation et signalisation des cassures double-brin de l'ADN lors d'un blocage de la transcription
... To assess the potential role of RhoB in the cellular response to CPT, we compared survival of WT and RhoB-deficient RhoB⫺/⫺ E6-immortalized MEF cells after CPT treatment.. Cells were tre[r] ... Voir le document complet
307
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
... DSBs and genomic insta- bility ( Aguilera and Garcı´a-Muse, 2012; Sollier and Cimprich, 2015 ...analysis in non-replicating cells suggests that a DSB does not form directly in the ... Voir le document complet
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The Secret Life of Chromosome Loops upon DNA Double-Strand Break
... The DNA Double Strand Break response and repair DNA Double Strand Breaks (DSBs) represent challenging lesions for cells, as they can lead to major ... Voir le document complet
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New Topoisomerase I mutations are associated with resistance to camptothecin.
... mutations in HCT116 resistant cells could influence DNA fork progression (in particular stalling or ...used DNA combing to analyze the progression of sis- ter replication forks ... Voir le document complet
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Transcription-coupled TA and GC strand asymmetries in the human genome
... no strand bias conditions, the following equalities A = T and G = C should be observed in each DNA strand [1] ...studied in prokaryotic, organelle and viral genomes ... Voir le document complet
4
Ku counteracts mobilization of PARP1 and MRN inchromatin damaged with DNA double-strand breaks
... relevant to genomic instability associated with cancer, its components and regula- tion are still largely ...unknown. To get insights into this pathway, we have knocked-down Ku, the main contributor ... Voir le document complet
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[Bacterial infections as seen from the eukaryotic genome: DNA double strand breaks, inflammation and cancer].
... ADNase I telle que CDT, les mécanismes précis conduisant aux dommages de l’ADN (cassures double-brin, simple-brin, ...cassures double-brin de l’ADN se produisent dans un contexte d’inflammation ... Voir le document complet
8
AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells
... by DNA double-strand breaks in colorectal cancer cells Nina Seiwert 1,6 , Carina Neitzel 1,6 , Svenja Stroh 1 , Teresa Frisan 2 , Marc Audebert 3 , Mahmoud Toulany 4,5 , Bernd Kaina 1 ... Voir le document complet
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Trapping of Mammalian Topoisomerase I and Recombinations Induced by Damaged DNA Containing Nicks or Gaps
... topoisomerases I (top1) and oligonucleotides containing a unique top1 cleavage site to study top1-mediated cleavage and recombination in the presence of nicks and short gaps ... Voir le document complet
8
C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.
... pairing DNA double strand breaks in eukaryotes and many ...binds DNA ends and recruits other factors which can access DNA ends through the threading of Ku inward ... Voir le document complet
23
Cationic Pd(II) complexes acting as topoisomerase II inhibitors: Synthesis, characterization, DNA interaction and cytotoxicity.
... lower frequency for the νC_S band after coordination. Variation of ~ 4 ppm down field of the chemical shift ( 1 H NMR) was observed for the two N2 protons after complexation. ESI/MS spectra con firmed the expected ... Voir le document complet
4
DNA binding, topoisomerase inhibition and cytotoxicity of palladium(II) complexes with 1,10-phenanthroline and thioureas.
... cisplatin. Complexes 2 and 3 were more active than 1 in both KB and MCF7-R ...From DNA binding experiments, it can be suggested that for these compounds the ancillary ligand does not ... Voir le document complet
7
Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining
... A DNA double strand break (DSB) is a highly toxic lesion, which can generate genetic instability and pro- found genome ...required to generate diversity during physiological ... Voir le document complet
21
Signaling of double strand breaks and deprotected telomeres in Arabidopsis
... necessary to maintain genomic integrity ( Culligan et ...the break by PIKK is an early cellular response to the induc- tion of DSBs and occurs over 50 kb in yeast to 2 Mb ... Voir le document complet
7
True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair
... meC to cytosine by the direct removal of the methyl group or by the hydrolytic deamination of meC to thymine further excised by a DNA repair ...reaction and implies apolipoprotein B mRNA ... Voir le document complet
12
Physical interaction between the histone acetyl transferase Tip60 and the DNA double strand breaks sensor MRN complex
... Tip60 and MRN proteins in GST-pull down experiments (data not shown) suggesting that the interaction is not ...known to be physically associated with Tip60 on one hand [6] and with the MRN ... Voir le document complet
19
Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA
... repairing DNA adducts in ds- and ss-DNA, respectively, and were also tested on those ...enzymes to repair the four methylated bases was tested in vitro using a previously ... Voir le document complet
16
JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage
... on DNA damage signaling and repair could be direct by assessing the recruitment of GFP-tagged JMJD6 to sites of laser induced-DNA dam- age using live cell ...at DNA damage induced ... Voir le document complet
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BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
... developed to assess DSBs at genomic scale, including chromatin immunoprecipita- tion sequencing 7,8 , direct in situ breaks labeling, enrichment on streptavidin and next-generation sequencing (BLESS) ... Voir le document complet
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