[PDF] Top 20 ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis
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ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis
... molecules and extracellular matrix components (for review Koller et al, ...proform, ADAM8 can dimerize or multimerize and autocatalytically clip off its prodomain, leaving an active mem- ... Voir le document complet
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miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.
... Results ADAM8 regulates miRNA expression in MDA-MB-231 TNBC cells ADAM8 is synthesized as a multidomain proteolytically inactive proform protein (120-kDa), which can autocata- lytically clip ... Voir le document complet
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Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance
... the invasive switch by loss of NME1 in the intraductal xenograft model Intra-nipple injection of human breast carcinoma ...cells in the mammary glands of SCID mice generate intraductal tumors ... Voir le document complet
15
Asthma-related inflammation promotes lung metastasis of breast cancer cells through CCL11–CCR3 pathway
... probably in a CCL11–CCR3–dependent man- ...increased cancer cells dissemination to lungs of Balb/c mice immunized and challenged with inhaled ovalbu- min; (ii) the higher expression of ... Voir le document complet
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Tumor cell and stromal cell interactions during breast cancer progression
... National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA With the sequencing of the human genome completed the functional elucidation for all expressed genes has become the predominant ... Voir le document complet
8
Stromal integrin alpha11 regulates PDGFR-beta signaling and promotes breast cancer progression.
... The tumor-promoting capacities of CAFs have been widely described as being related to their secretome and ability to remodel the extracellular matrix ...promote cancer cell invasion in a ... Voir le document complet
53
Adhesion-GPCRs in cancer progression and metastasis
... domains in the extracellular region that commonly mediate cell-cell and cell-matrix interactions in various ...diverse cancer types have revealed significant alterations (copy number ... Voir le document complet
161
Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis
... proteins in the bone metastasis and the primary tumor have been previously associated with cell migration and/or tumor ...was in favor of the acquisition of a ... Voir le document complet
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Aberrant Glycosylation Promotes Lung Cancer Metastasis through Adhesion to Galectins in the Metastatic Niche
... clinical and experimental evidence has suggested a role for interleukin 6 (IL-6) in cancer metastasis (19, 21, ...42–44). Tumor-derived soluble factors, including a variety of ECM ... Voir le document complet
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Role of KCNMA1 gene in breast cancer invasion and metastasis to brain.
... genome-wide expression analysis of breast cancers, such as adjusting the intensity of current chemotherapy based on cancer subtypes as defined by gene expression signatures ...action. ... Voir le document complet
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Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance
... of breast tumor specimens based on highly discriminating antibodies revealed an up-regulation of NME1 levels in carcinoma cells in DCIS tumors as compared to surrounding non-malignant tissues, ... Voir le document complet
15
BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance
... metastatic dissemination without promoting cell proliferation Prior studies have yielded conflicting results about BMI1 expression in melanoma, with one study concluding that BMI1 increases with ... Voir le document complet
18
Role of the microtubule-associated protein ATIP3 in cell migration and breast cancer metastasis
... Metastatic cancer cells were injected intracardiacally into the bloodstream of nude mice to reca- pitulate the late, rate-limiting, steps of the metastatic process, and examine metastatic ... Voir le document complet
245
en fr Role of the Thrombospondin 1 in Tumor Migration, Invasion and Metastatic Dissemination in Prostate Cancer and Breast Cancer Rôle de la thrombospondine-1 dans la migration, l’invasion et la dissémination métastatique dans les carcinomes prostatiques et mammaires
... tumors and metastasis in TSP-1-null-Pyt transgenic mice (Yee et ...tumors in Pyt transgenic mice, tumors spontaneously arising in TSP1 null mice were larger and their blood ... Voir le document complet
139
ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer
... increased expression of sALCAM in uterine aspirates from patients with moderately-poorly differentiated EEC presenting myometrial invasion ...>50%. In our study, ROC analysis corroborated sALCAM ... Voir le document complet
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The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.
... regulate cancer cell inva- sion is by remodeling the matrix via contraction ( Calvo et ...fibers and increases matrix stiffness ( Calvo et ...stiffness promotes cancer cell invasion and ... Voir le document complet
15
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
... board and has reported honoraria from Amgen, Novartis and ...board and consultancy for BMS; travel funding from Roche, Merck, and Astra ...Lilly and Novartis and is a Paid ... Voir le document complet
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[Circulating tumor cells and breast cancer: detection techniques and clinical results]
... L’équipe du MD Anderson et du CALG-B a publié plusieurs analyses de la même cohorte de patientes, le nombre de patientes incluses dans chaque étude variant avec les critères d’éligibilité. Le seuil de positivité ... Voir le document complet
3
Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers.
... recent in vitro studies have shown that TCSF is able to stimulate the production of several MMPs by ...1 and gelatinase A but not stromelysin 3 in fibroblasts (Kataoka et ...TCSF in ... Voir le document complet
7
VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
... blotting, and immunoprecipitation Anti-VOPP1 polyclonal antibody was produced by inoculat- ing rabbits with two distinct VOPP1 peptides corresponding to amino acids 101-116 (TRQPPNPGPGTQQPGP) and amino ... Voir le document complet
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