TRANS-RETINOIC ACID
Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review
... into retinoic acids. All-trans retinoic acid (ATRA), which has pro-differentiating properties, has revolutionized the prognosis of acute promyelotic leukemia by increasing its remission rate ...
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All-trans-retinoic acid represses chemokine expression in adipocytes and adipose tissue by inhibiting 1 NF-κB signaling 2 3
... [10] Bonet ML, Canas JA, Ribot J, Palou A. Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity. Arch Biochem Biophys. 2015;572:112-25. [11] Tourniaire F, Gouranton E, von ...
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All-trans retinoic acid induces oxidative phosphorylation and mitochondria biogenesis in adipocytes
... all- trans retinoic acid (ATRA) on white adipose tissue (WAT) oxidative and thermogenic ca- pacity has been described and linked to an in vivo fat-lowering effect of ATRA in ...
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Complex context relationships between DNA methylation and accessibility, histone marks, and hTERT gene expression in acute promyelocytic leukemia cells: perspectives for all‐ trans retinoic acid in cancer therapy
... ATRA-induced repression of hTERT was associated with a global decrease of CpG methylation level in the region I (from 23.7% to 9.4%), suggesting that the methylation status of the proxim[r] ...
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Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
... Seeking to determine whether AML cell lines en‑ gineered to express either the WT or mutant form of IDH1 (Fig. 1 A) and controlled for their production of 2‑HG and α‑ketoglutarate (α‑K[r] ...
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The role of R-spondin3 in coronary artery formation and novel roles for retinoic acid signaling in cardiac development and repair
... The very strong and specific labeling of cardio-myoblasts contradicts previous reports which suggest RA’s activity to be restricted to the epicardial and sub-epicardial layers at these time-points (Brade et al., 2011; ...
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Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms.
... three retinoic acid receptors (RARa, -b, and -g) and three reti- noid-X-receptors (RXRa, -b, and -g) which form RAR/ RXR heterodimers that are believed to correspond to the in vivo mediators of the ...
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An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist
... Introduction Retinoic acids and their analogs, referred to as retinoids, exert their pleiotropic effects through three retinoic acid receptor subtypes [RAR α (NR1B1), RARβ (NR1B2) and RARγ (NR1B3)] ...
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Retinoic acid sensitivity of triple-negative breast cancer cells characterized by constitutive activation of the NOTCH1 pathway : the role of RARβ
... Abstract: Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative ...
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Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner.
... 37°C in a 5% CO 2 - 95% air atmosphere. In some experiments, charcoal-stripped FCS was used to alleviate the potential influence of FCS-contained lipids (e.g. retinoids). No difference in the outcome of the experiments ...
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Crosstalk between retinoic acid and sex-related genes controls germ cell fate and gametogenesis in Medaka
... the retinoic acid receptor alpha, and all-trans-retinoic acid ATRA (10 nM) were added to the medium and medium changed every 2 ...
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Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary
... All-trans retinoic acid (ATRA) signaling is considered the key pathway that promotes Stra8 (stimulated by retinoic acid 8) expression and, in turn, meiosis ...
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Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium
... every 8.6 days, whereas their descendants are generated and displaced at a constant pace towards the lumen of the seminiferous tubules. These processes result in the formation, at a given point along a seminiferous ...
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Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns
... all-trans retinoic acid (atRA); the other groups were treated with eye drops six times daily, and these comprised homogenates of AM that were untreated or pretreated with ...
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PLZF is a negative regulator of retinoic acid receptor transcriptional activity.
... The exact biological role of PLZF remains to be estab- lished. However, its localization to nuclear bodies [11], which are nuclear structures associated to a central, tran- scriptional regulatory role [12], as well as ...
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Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α
... the retinoic acid receptors (RAR) and the retinoid X receptors (RXR), which have distinct cellular functions and are expressed in a variety of tissues including the kidney 12 ...all- ...
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Effects of a trans isomer of arachidonic acid on rat platelet aggregation and eicosanoid production
... Tram n-3 eicosapentaenoic and docosa- hexaenoic acid isomers exhibit different inhibitory effects on arachidonic acid metabolism in human platelets com- pared to the respective ci[r] ...
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Mechanisms of retinoic acid signaling during cardiogenesis
... of retinoic receptors in cardiac lineage spec- i ...). Retinoic receptors can mediate looping of distant DNA sequences, enabling transcriptional regulation by far-upstream en- hancers ( Yasmin et ...
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Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.
... ABSTRACT Retinoic acid (RA) is known to be required at various levels of eye patterning via Retinoic Acid Receptors (RAR); however the molecular and cellular mechanisms triggered by these ...
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Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling
... Primary aldosteronism (PA) is the most frequent form of secondary arterial hypertension. Mutations in different genes increase aldosterone production in PA, but additional mechanisms may contribute to increased cell ...
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