suppressor cells
A dynamic metabolic flux analysis of myeloid-derived suppressor cells confirms immunosuppression-related metabolic plasticity
... myeloid-derived suppressor cells (MDSCs) maturation and ...dendritic cells, granulocytes, to name only the most abundant cell types 2 ...These cells metabolize the semi-essential amino acid ...
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Early expansion of circulating granulocytic myeloid-derived suppressor cells predicts development of nosocomial infections in septic patients
... S UPPLEMENTAL METHODS Quantitative real-time PCR Total RNA was extracted using PAXgene blood RNA kit (Qiagen). cDNA was then generated using Multiscribe Reverse Transcriptase and High-Capacity cDNA reverse Transcription ...
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Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma
... Treg cells are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral ...These cells regulate a diverse array of immune responses in the context of ...
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Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow
... [64] Feng, P.-H., Lee, K.-Y., Chang, Y.-L., Chan, Y.-F., Kuo, L.-W., Lin, T.-Y., Chung, F.-T., Kuo, C.-S., Yu, C.-T., Lin, S.-M., Wang, C.-H., Chou, C.-L., Huang, C.-D., Kuo, H.-P. (2012) CD14(+)S100A9(+) monocytic ...
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Deciphering myeloid-derived suppressor cells isolation and markers in humans, mice and non-human primates
... immune cells may increase pathology and suppress host-protective immune ...Myeloid cells show high plasticity and adapt to changing conditions and pathological ...myeloid cells is still poorly ...
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Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models
... BM cells to GM-CSF and IL-6 activated, within 24 h, L-Arg metabolizing enzymes which are responsible for the MDSCs immunosuppressive ...MSC-1 cells down- regulated central carbon metabolism activity, ...
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Myeloid-Derived Suppressor Cells in Hematologic Diseases: Promising Biomarkers and Treatment Targets
... these cells and their precise role in the microenvi- ronment of BM and lymphoid tissues in malignant and immune- mediated hematologic disorders undoubtedly need further ...
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en fr Myeloid-derived suppressor cells in septic patients Cellules suppressives d'origine myéloïde au cours du sepsis
... dendritic cells obtained by in vitro differentiation of monocytes showed that bioactive enzyme is inconstantly induced by various combinations of IFN-g, cy- totoxic T-lymphocyte antigen 4 (CTLA-4), CD40-Ligand, ...
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HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis
... helping cells to adapt to a difficult ...some cells of the immune system, such as myeloid cells, may also have unwanted ...derived suppressor cells (MDSC) in the tumor microenvironment ...
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Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB
... HCT116 cells were transfected with three TP53 mutants, selected as representative of different classes of mutants (Figure ...HCT116-p53/ cells, these mutants did not show any capacity to increase Cox-2 ...
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FGFR3 has tumor suppressor properties in cells with epithelial phenotype.
... HCT116 cells being inhibited by FGFR3 ...SW480 cells, and the main conclusions of the report were drawn based on this cell line ...HCT116 cells express high levels of E-cadherin and low levels of ...
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Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?
... tumour suppressor gene by muta- tions and allelic losses, or through the presence of β-cat- enin activating mutations ...tumour suppressor gene that remains to be ...
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Tumor suppressor fumarate hydratase is phosphorylated and regulated by AMP-activated protein kinase
... # Contributed equally. AMP-activated protein kinase (AMPK) is a central cellular signaling hub involved in energy homeostasis, growth and proliferation. The kinase is considered as a promising target for pharmacological ...
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Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer
... 67NR cells [ 48 ] and up-regulated it in 4T1 cells by shRNA and cDNA overexpression, respectively (Figure ...S4a,b). Cells were then orthotopically injected in the fat pad of the 4th mammary gland ...
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Downregulation of putative tumor suppressor gene TSC-22 in human brain tumors.
... HSC-39 cells transfected with a TSC- 22–expressing vector showed a significant decrease in cell viability and elicited apoptotic cell death through the activation of CPP32-like protease because the syn- thetic ...
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The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
... PA-1 cells were transfected in 10 cm tissue culture plates with 4 µg of FLAG-AGO2 and 25 nM of scr/mimic let-7 using lipofectamine 2000 ...post-transfection, cells were washed with ice- cold 1× PBS, ...
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VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
... MD-MB-468 cells were transfected with control (Si-Ctrl) and VOPP1 siRNAs (Si-VOPP1) for 3 ...MD-MB-468 cells were transfected with control, VOPP1, and WWOX siRNAs as ...later, cells were collected ...
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Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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The transcriptional activator $HAP4$ is a high copy suppressor of an $oxa1$ yeast mutation
... 3.3. HAP4 over-expression strongly increases the steady- state level of Cox2p in the oxa1-DL1-K332* mutant Lascaris et al. (2003) have shown that cells over- expressing HAP4 up-regulate genes involved in mitochon- ...
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MODELLING NUCLEOCYTOPLASMIC TRANSPORT WITH APPLICATION TO THE INTRACELLULAR DYNAMICS OF THE TUMOR SUPPRESSOR PROTEIN P53
... stem cells, p53 is cytoplasmic, as gure ...stem cells (D3), where p53 is labelled by a green GFP tag, and the nucleus is visualized using a uorescent (blue) DNA-interactive agent ...healthy cells, ...
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