NER: Nucleotide-Excision Repair
La « guerre » du NER (nucleotide excision repair)
... [10] . Ces conditions sont plus proches de la réalité physiologique puisque, dans la cellule, le nombre de lésions induites par un flux d’UV de 1 joule/m 2 est seule- ment de 2,4 x 10 - 5 lésions par 1 000 pb d’ADN [11] ...
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Nucleotide excision DNA repair pathway as a therapeutic target in patients with high-risk diffuse large B cell lymphoma.
... machinery. NER removes helix-distort- ing adducts on DNA and contributes to the repair of ICLs ...adducts repair pathways. Furthermore, NER deficiency is associated with a reduced capacity to ...
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Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients.
... DNA repair genes from the Nucleotide Excision Repair (NER) ...pathway. NER involves more than 20 proteins whose inactivation leads to Xeroderma pigmentosum (XP) or Cockayne ...
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Repair by basic excision at the mitochondrial level in Drosophila. Analysis of a potential actor in this process : the PARP protein
... DNA repair in mitochondria From 1974 Clayton and collaborators show that mitochondria are unable to repair pyrimidine dimers and some types of alkylation damage (Miyaki, et ...DNA repair mechanisms ...
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Régulation dépendante du cycle cellulaire de la réparation par excision de nucléotides
... Global-genomic nucleotide excision repair (GG-NER) is the only pathway available to humans for removal, from the genome overall, of highly genotoxic helix-distorting DNA adducts generated by ...
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en fr Involvement of TFIIH in NER factors mediated chromatin remodeling Contribution de TFIIH dans le remodelage de la chromatine dépendant des facteurs NER lors de la transcription
... B. NER Factors The NER factors are the group of proteins which are known to be involved not only in NER pathways but also in several DNA repair ...the nucleotide excision ...
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Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli
... The following parameters have been used: Alternatively, gap enlargement may result from the necessity to allow a RecA filament to assemble downstream from the lesion in order to activate Pol V [ 47 ]. The gap-filling ...
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True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair
... the NER defect because this defect targets specific genes, under specific conditions, and probably in a cell- specific ...of repair factors in gene ...
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en fr La réparation par excision de nucléotides à la croisée des chemins avec la transcription Nucleotide Excision Repair at the crossroad with transcription
... DNA repair is completed ...DNA repair completion, RNAP1 transcription restarts in ACTβ and NMI depleted cells as in siMock-treated ...coupled repair pathway ...DNA repair deficiency, we ...
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Du nouveau sur la régulation de la réparation de l’ADN par excision de nucléotides
... la NER. Ainsi, les tumeurs présentant un défaut de la NER pendant la phase S pourraient répondre plus sélectivement à ces agents thérapeutiques, permet- tant ainsi l’élaboration de stratégies qui pourraient ...
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Aligning Protein-Coding Nucleotide Sequences with MACSE
... had to build more than 20,000 alignments containing up to 116 sequences that could be several Kb long. We designed a pipeline based on MACSE v2 that is well suited for this task. The filtering steps are similar to those ...
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Transcripts with systematic nucleotide deletion of 1-12 nucleotide in human mitochondrion suggest potential non-canonical transcription
... General discussion and future prospects In this study we tested a phenomenon of systematic nucleotide deletion during transcription in three independent datasets. Results confirm the working hypotheses that ...
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Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster. I. Induction by inhibitors of nucleotide synthesis and by gamma rays.
... Unexpectedly, it appeared that fluo- rodesoxyuridine (Fudr) had an enhancing effect on the levels of reactivity (A. BUCHETON, personal communica- tion). No interpretatio[r] ...
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Réparation par excision de nucléotides des dommages induits par rayons ultraviolets dans les mélanomes humains
... NER status and ATR activity during S phase in human MM cell lines; (iii) To investigate whether frequently mutated genes in melanoma ...phase-specific NER in MM cell ...photoproducts repair and ATR ...
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Cytidine- and guanosine-based nucleotide–lipids
... The modulation of the polar head structure, in particular the nature of the base could influence the aggregation properties of the NLs. Therefore, we elected to design NLs with a double dipalmitoyl glycerol phosphate ...
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Tissue repair modeling
... DC consists of the migration of lateral epidermal cells towards the mid- line covering this opening (the amnioserosa) in a couple of hours (see movie DC.mov). This process does not invol[r] ...
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Rapport final. Volet quantitatif du projet Excision et Handicap (ExH).
... On note en outre, pour les trois types de difficultés rencontrées, des proportions importantes de femmes qui déclarent ne pas savoir pas si ces gênes ressenties sont liées à la mutilation qu’elles ont subie. Ce constat ...
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Rapport final. Volet qualitatif du projet Excision et Handicap (ExH)
... « J’ai eu un gynécologue depuis l’âge de 16 ans. A aucun moment, j’ai un gynécologue qui m’a dit « Oh, mademoiselle, vous êtes excisée… ». Jamais. Jamais, jamais, jamais… Jusqu’à pas longtemps, d’ailleurs, juste avant ...
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Patch repair: compatibility issues
... crete Repair Manual (2003): “It is also important that the repair material has mechanical properties compatible with those of the substrate concrete to ensure that the materials will act as one and no mate- ...
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The Path-repair algorithm
... We also tested a tabu version of path-repair . Table 1 presents the results ob- tained on a series of 30 problems from Taillard [27]. In order to put in per- spective our results, we recall results presented in ...
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