CXCL12/CXCR4
Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway
... of CXCR4 is further supported in our study by in vitro ...a CXCR4 antagonist on GBM explants isolated from three patients and demonstrated a greater anti-tumor effect with the combination of AMD3100 and ...
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Effets du bisphénol A (BPA) sur l’expression de l’axe CXCL12/CXCR4 dans l’endométriose et le cancer endométrioïde de l’ovaire
... que CXCL12/CXCR4, un axe œstrogèno-dépendant, joue un rôle important dans l’homéostasie cellulaire et contrôle la migration des cellules dans les conditions normales et ...de CXCL12/CXCR4 et ...
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Adult mouse sub-ventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12/CXCR4 signaling
... vivo CXCL12/CXCR4 signaling, using ei- ther lentiviral vectors allowing the expression of specific CXCR4 shRNAs or blocking CXCR4 with a specific antagonist (AMD3100) led to the same ...
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The CXCL12/CXCR4 pathway or the autocrine proliferative loop of the glioblastoma stem cells
... The recent study of Calinescu et al. (5) specifically address the question of GSC as those cells have been demonstrated to be resistant to chemo- and radiotherapy (6,7) and responsible for promoting neo-angiogenesis in ...
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Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer
... increasing CXCL12 gradient from the primary tumor to secondary niches at metastatic ...that CXCL12 is highly expressed in hepatic sinu- soids including endothelial and Kupffer cells [38] and that ...
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Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer
... on CXCL12 as a relevant target based on its known roles in immunosuppression in other cancer ...the CXCL12 receptor CXCR4 is highly expressed in both human primary tumors and ...the ...
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Structural and functional study of the interaction between CXCL12 chemokine and its receptors : CXCR4 and ACKR3/CXCR7
... the CXCL12 chemokine and its G-protein–coupled receptor (GPCR) CXCR4 is highly conserved among vertebrates being essential for development, and critical for numerous homeostatic functions such as cell ...
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CXCR4, une cible thérapeutique dans certains déficits immunitaires rares?
... l’axe CXCL12/CXCR4. L’AMD3100, un antagoniste sélectif de CXCR4 et connu pour ses propriétés mobilisatrices, constitue un bon can- didat et pourrait orienter l’arsenal thérapeutique chez les patients ...
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Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic lupus erythematosus.
... receptor CXCR4, constitutes the chemokine/receptor axis attracting the greatest level of interest in autoimmunity ...express CXCR4 and CXCL12 is constitutively pro- duced by stromal, epithelial, and ...
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CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development
... + Cxcr4 + cell population, but the loss of Mist1 + cells Figure 4: Cxcl12/Cxcr4 axis contributes to antral stem cell ...of Cxcr4-EGFP; Cxcl12- dsRED mice stained with ...of ...
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La chimiokine CXCL12 et le papillomavirus humain - Une piste pour la pathogenèse du syndrome WHIM
... paire CXCL12/CXCR4 Nous avons cherché à caractériser les liens observés entre CXCL12 et l’infec- tion par HPV et, en premier lieu, nous avons déterminé s’ils pouvaient être reproduits in ...de ...
3
Neutralization of CXCL12 attenuates established pulmonary hypertension in rats Short Title: CXCL12 neutraligands in severe PH in the rat
... The CXCL12/CXCR4/CXCR7 axis directly contributes to cell migration, a phenomenon that plays a key role in the muscularization of distal pulmonary arteries in PAH 9, 25 ...the CXCR4 and CXCR7 ...
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en fr Involvement of the chemokines CXCL12 and CX3CL1 in the pathophysiology of the trabecular meshwork and ocular surface in glaucoma Rôle des chimiokines CXCL12 et CXCL1 dans la physiopathologie du trabéculum et de la surface oculaire au cours du glaucome
... chimiokine CXCL12 présente des fonctions extra- immunitaires, notamment un rôle dans la régulation de la viabilité cellulaire et de la composition de la matrice extracellulaire via ...de CXCL12 produisait ...
204
La chimiokine CXCL12 et son récepteur CXCR4 dans le contrôle des infections par les papillomavirus humains - Nouveaux facteurs de susceptibilité à la pathogénie virale
... chimiokine CXCL12 et ses récepteurs dans le cycle biologique des papillomavirus ...L’axe CXCL12/CXCR4-ACKR3 participe au contrôle du cycle biologique d’HPV en régulant la prolifération des ...
4
IL-4/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma
... of CXCL12 in ADSCs (Figure ...pos CXCR4 neg tonsil centrocytes, thus confirming the activation of IL-4 signaling in FL (Figure ...with CXCL12 staining across a large series of FL LN samples, as ...
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Optimisation de la domiciliation des cellules CD34+ de sang de cordon ombilical: élucider les mécanismes en cause dépendant du CXCR4
... 3.3 Observation de la prise de greffe dépendante de CXCR4. Les transplantations à partir de SCO comportent beaucoup d’avantages sur les transplantations à partir d’autres sources telles que la MO ou le sang ...
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Targeting of CXCR4+ Glioblastoma initiating cells with a retargeted oncolytic herpesvirus
... a CXCL12 gradient that attracts GBM cells, which have been shown to express CXCR4 (one of the two CXCL12 ...these CXCR4+ cells share characteristics with stem cells and are thus considered as ...
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Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration.
... chemokine CXCL12, we found that 1- CXCL12 induces a dynamic re- localization of CRMP2 to uropod, the flexible structure of migrating lymphocyte, and increases its binding to the cytoskeletal protein ...
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Targeting of CXCR4+ Glioblastoma Initiating Cells with a retargeted oncolytic herpesvirus
... Glioblastoma is the most common and aggressive primary brain tumor in adults. Surgical resection followed by radiotherapy and/or chemotherapy is the standard treatment. However, despite improvement of these treatments, ...
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CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury.
... role of the Cxcl12a/Cxcr4b signaling pathway in the immediate response to injury. Zebrafish myca is required for a normal repair response. Zebrafish myca was prominently expressed along the pronephros and the cloaca at ...
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