APOLIPOPROTEIN E-DEFICIENT MICE
Inulin attenuates atherosclerosis in apolipoprotein E-deficient mice
... Inulin: Oligofructose: Apolipoprotein E-deficient mice: Atherosclerosis Atherosclerosis is an important risk factor of CVD (Charakida et al. 2006), which is one of the major causes of ...
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Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS
... apoE is expressed in the CNS in resident immune cells and has been implicated in different immunoregulatory functions [1, 2, 23]. For instance, in a recent study, milder disease in apoE-deficient mice was ...
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Derlin-2-Deficient Mice Reveal an Essential Role for Protein Dislocation in Chondrocytes
... Metabolic labeling and pulse chase experiments: Cells were starved in methionine- and cysteine-free medium containing dialyzed serum for 1 hr, then pulse-labeled for 20 min (unless otherwise indicated) with 250 µCi/ml of ...
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Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration
... GFP/GFP mice as a model of subretinal inflammation, we show that increased expression of APOE, observed in Cx3cr1 GFP/GFP MPs, is associated with significant acute (laser- and light-induced) and chronic ...
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Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease
... ) mice display impaired ubiquitination and degradation of synaptic vesicle associated proteins [ 22 ], mitochondrial dysfunc- tion and increased sensitivity to oxidative stress in dopaminergic neurons [ 25 ...
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Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice
... -/- mice inhibits abdominal pain. (A) Colonic sensitivity of IL-10 -/- mice fed with standard chow diet containing (black circles) or not (white circles) piroxicam was measured by colorectal ...-/- ...
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Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice
... Igf2-deficient mice was identical than the CD11c ⫹ population from wt ...mutant mice after dif- ferentiation and maturation (data not ...wt mice, LPS treatment promoted overexpression of these ...
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Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor
... high-power fields were used) per tissue section generated from 5 mice per neoplastic stage. Data presented reflect the average total count (cells or lymphatic vessels) per field from ventral ear leaflet. ...
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Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins
... endpoint. Our study contrasts somewhat with previous reports showing that inhibition of Mgmt through the delivery of the inhibitor O 6 -benzylguanine had no effect apoptosis induced by the S N 1 alkylating agents MNU and ...
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Disrupted fatty acid distribution in HDL and LDL according to apolipoprotein E allele
... The lower levels of 16:0 and 16:1 n−7 in HDL and LDL of E4+ compared to E4− is an example of APOE isoform-dependant modification of FA distribution in plasma lipoproteins. As suggested in previous studies [7, 33], this ...
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Kinetics of plasma Apolipoprotein E isoforms by LC-MS/MS: a pilot study
... LAVYQAGAR). Apolipoprotein quantification – Chromatographic peak area ratios between unlabeled peptides (M0) and their respective ISs constituted the detector ...samples. Apolipoprotein concentrations were ...
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The use of an adapted model allows contributing to the “Reduction” of mice used in experimental protocols: the case of the apoE–deficient (apo E-/-) mice in a model of atherosclerosis control
... The present study was undertaken in order to investigate whether BM-573, an original sulfonylurea derivate synthesized in our lab 5 , and aspirin would be effective in preventing the progression of atherosclerosis in an ...
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Colonic Proteome Signature in Immunoproteasome-Deficient Stressed Mice and Its Relevance for Irritable Bowel Syndrome
... The mitochondrial cluster accounted for 33% of the identified proteins and included: ATP synthase subunit beta (Atp5b), Elongation factor G1 (EF-G1mt), Elongation factor G2 (EF- G2mt), Electron transfer flavoprotein ...
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Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training
... marker Bnf was not clearly modulated by exercise or lack of NMRK2 (Figure 2D). The Myh7 gene encoding the slow β-MHC was increased in only one sedentary Nmrk2 −/− mouse that did not show any other major diffference in ...
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Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles.
... It is interesting that marginal apoE silencing reduces extracellular/supernatant infectivity, but not intracellular infectivity (fig 6). To further address the impact of a[r] ...
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A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)
... 2 ways of vaccination against S.pneumoniae Characteristics of Ghrh -/- immune system in basal conditions: ↗ TREC, ↗ naive T cells, ↙↙ B cells . Therefore, we investigated the B-dependent vaccine and immune responses of ...
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A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)
... A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH) K. FAHRAT*, G. BODART*, C. RENARD*, C. DESMET 1 , M. MOUTSCHEN 2 , Y. BEGUIN 3 , F. ...
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Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux
... Lipid-free apolipoprotein E3 (LF-apoE3) induces an ATP-binding cassette subfamily G member 1 protein (ABCG1)-dependent cholesterol ef flux that inhibits HCV ...
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Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: Interaction with apolipoprotein E genotype
... Several prospective epidemiological studies have suggested a protective role of fish consumption [7-11] or dietary n-3 PUFA [9] against risk of dementia or Alzheimer’s disease (AD). However, conflicting results exist as ...
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High Glycemic Load Is Associated with Cognitive Decline in Apolipoprotein E epsilon4 Allele Carriers
... Received: 12 October 2020; Accepted: 23 November 2020; Published: 25 November 2020 Abstract: Recent evidence suggests that a high glycemic load (GL) diet is a risk factor for dementia, especially ...
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