allogeneic nK cells
Activated Allogeneic NK Cells Preferentially Kill Poor Prognosis B-Cell Chronic Lymphocytic Leukemia Cells
... DiscUssiOn Allogeneic NK cells have been shown to be effective in the treat- ment of poor prognosis acute myeloid and lymphoid leukemia (AML and ALL) ( 34 , 37 – 42 ...that allogeneic ...
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Expansion of allogeneic NK cells with efficient antibody-dependent cell cytotoxicity against multiple tumors
... allogeneic NK cells in clinical trials for cervical cancer [39]. In fact, in vitro and clinical data suggest that cetuximab mediates ADCC through NK cells [22, 34] _ENREF_35 . We ...
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Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance
... of allogeneic natural killer (NK) cells is becoming a credible immunotherapy for hematological ...human NK cells, we generate expanded NK cells (eNK) with increased ...
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Naturally improving the natural cytotoxicity of natural killer (NK) cells
... of allogeneic NK in different tumor treatments described above, their use in infectious diseases is clinically ...that NK cells play a major role in the immunity against all these pathogens, ...
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Conditional ablation of NKp46+ cells using a novel Ncr1greenCre mouse strain: NK cells are essential for protection against pulmonary B16 metastases
... T cells (using CD4 and CD8 microbeads) and B cells (using CD19 microbeads) were depleted from thymocytes in order to enrich for thymic NK cells using MACS ...marrow cells suspensions ...
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Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function
... resident NK cells harbored an inhibited phenotype, with an impaired ...the NK cells response and the NK cells phenotype also seemed to be related with an aggravation of the ...of ...
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Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases
... For nK-LiKe Cd8( +) t CeLLs in HUMans In parallel with the previously described work on mice, sev- eral studies conducted in the early 2000s demonstrated the existence in humans of CD8(+) T cell-expressing ...
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en fr Regulation of NK cell function by TGF-ß Régulation des cellules NK par le TGF-β
... ADCC : Cytotoxicité dépendante des anticorps Antibody Dependant Cell Cytotoxicity CD : Cluster of Differentiation CILP : Progéniteur commun aux ILC Common ILC Progenitor CLP : Progéniteu[r] ...
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IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells
... IL-15Rα cells preculture ...responding cells after their separation from presenting ...responding cells. Together, these data suggest that once IL-15 responding cells are separated from ...
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NKp46 expression on NK cells as a prognostic and predictive biomarker for response to allo-SCT in patients with AML
... cytometry. Cells were immunostained with Krome Orange (KOTM)- or allophycocyanin (APC)-conjugated anti- CD45, fluorescein isothiocyanate (FITC)–conjugated or Phycoer- ythrin-Cyanine 7 (PC7)- or Phycoerythrin-Texas ...
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Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells
... of NK cells has been shown to increase the level of surface expression of KIR2DL4 on NK cells with at least one 10A allele, both on CD56 dim and CD56 bright NK cell subsets ...that ...
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Peripheral Blood Plasmacytoid Dendritic Cells at Day 100 Can Predict Outcome after Allogeneic Stem Cell Transplantation
... of allogeneic stem cell transplantation (allo-SCT) emphasizes the need for iden- tifying variables predictive of its ...dendritic cells (pDCs) play a major role in estab- lishing immune competence and in ...
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Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients
... patients. Cells from MM patients were left untreated (MM), or they treated with daratumumab at 5 μg/ml (d), with pembrolizumab at 10 μg/ml (p), or with their combination (D + P), or incubated with PD-1-negative ...
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IKDC - Un nouveau costume pour les cellules NK activées
... les NK et les polynucléaires ; CD11b (une autre chaîne α des intégrines), tou- jours associée à CD18, est présente à la surface des cDC, des NK, et des cellules granulo-macrophagiques ; B220 (une isoforme ...
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Une piste en immunothérapie du cancer - Cibler la signalisation des cellules NK
... cellules NK dont les gènes DOK1 et DOK2 auraient été ...cellules NK, partici- pant ainsi au blocage de l’activité ...cellules NK issues de donneurs humains et ont permis le dévelop- pement d’un ...
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Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques
... beta cells is an ability to detect glucose changes in extracellular solutions and secrete ...encapsulated allogeneic islets secreted statistically higher levels of insulin under high glucose compared to low ...
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en fr Unleashing NK cell signaling to improve cancer immunotherapy: Cibler la signalisation des cellules NK Une piste en immunothérapie du cancer
... cellules NK dont les gènes DOK1 et DOK2 auraient été ...cellules NK, partici- pant ainsi au blocage de l’activité ...cellules NK issues de donneurs humains et ont permis le dévelop- pement d’un ...
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Where are Bottlenecks in NK Fitness Landscapes?
... {verel,pc,clerguem}@i3s.unice.fr Abstract- Usually the offspring-parent fitness correla- tion is used to visualize and analyze some caracteristics of fitness landscapes such as evolvability. In this paper, we introduce a ...
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Des cellules NK mémoire découvertes chez les primates
... cellules NK se rapprochaient des lymphocytes T par différents aspects, comme la possibilité d’expansion clonale et de persistance à long terme après une activation, la capacité de réponse mémoire, notamment suite ...
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Régulation des cellules NK par les adaptateurs de la famille SAP
... Plusieurs expériences peuvent être réalisées grâce à ces souris : d’une part tester la capacité de lyse et de production des cellules NK CD48’ et d’autre part utilisé des cellules issue [r] ...
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