Supplementary Table 1.
Predicted TFBSm for NZF-2b/7ZFMyt1 on cocaine-responsive gene promoters.
No Gene Symbol Gene name P-Value Locus ID No. of
predicted
conserved modules 1 MAPK8 Mitogen activated protein kinase 8 0.0291524 Loc116554 11
2 Slc6a4 Serotonin transporter 0.0196873 Loc25553 3
3 Map2k1 Mitogen activated protein kinase kinase 1 0.04317 Loc5604 10 4 Cart Cocaine and amphetamine regulated transcript 0.307636 Loc29131 8
5 Efnb1 Ephrin B1 0.063931 Loc13641 4
6 SEMA4C semaphorin 4C pecursor like 1 0.00012015 Loc54910 6
7 SEMA6A semaphorin 6A 2.39E-06 Loc57556 13
8 Snca Synuclein alpha 0.00897996 Loc6622 18
9 Sncg Synuclein gamma 0.0291524 Loc6623 4
10 uPaR Urokinase plasminogen activator Receptor 0.455691 Loc5329 5
11 uPa Urokinase plasminogen activator 0.307636 Loc5328 3
12 CD81 CD81 antigen (target of antiproliferative
antibody-1) 0.207694 Loc12520 7
13 DAT Dopamine Transporter 0.063931 Loc6531 3
14 DRD3 Dopamine D3 Receptor 0.0291524 Loc1814 12
15 FOSB FBJ murine osteosarcoma viral oncogene
homologue B 0.207694 Loc2354 4
16 Fra2 Fos-related antigen 2 0.0227094 Loc79874 11
17 CREB1 cAMP responsive element binding protein-1 0.0291524 Loc1385 12 18 BDNF Brain derived neurotrophic factor 0.0176212 Loc627 13
Table 1. Experimental protocol for each group of animals used in open field locomotor activity experiment.
Days 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Sessions A Switch B Switch C Switch or Sacrifice
Doxycycline treatment
- - - + + + + + + + - - - - - - - - + + + + Activity
measurement
At the end of the experiment animals are sacrificed and brain tissues were utilized for immuno-histochemistry or qRT-PCR (see materials and methods).
Sacrifice
n=5 of each group
Rest (n=4)
of each group
