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HAL Id: tel-02092298

https://tel.archives-ouvertes.fr/tel-02092298

Submitted on 8 Apr 2019

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Tolérance et résistance aux antifongiques chez Candida spp. : caractérisation de nouvelles cibles thérapeutiques

Cécile Garnaud

To cite this version:

Cécile Garnaud. Tolérance et résistance aux antifongiques chez Candida spp. : caractérisation de nouvelles cibles thérapeutiques. Médecine humaine et pathologie. Université Grenoble Alpes, 2017.

Français. �NNT : 2017GREAS004�. �tel-02092298�

(2)

THÈSE

Pour obtenir le grade de

DOCTEUR DE LA COMMUNAUTÉ UNIVERSITÉ GRENOBLE ALPES

Spécialité : Modèles, méthodes et algorithmes en biologie

Arrêté ministériel : 25 mai 2016

Présentée par

Cécile GARNAUD

Thèse dirigée par Muriel CORNET et codirigée par Jérôme GOVIN

préparée au sein du Laboratoire TIMC-IMAG, équipe TheREx dans l'École Doctorale Ingénierie pour la Santé, la Cognition et l' Environnement (EDISCE)

Tolérance et résistance aux

antifongiques chez Candida spp. : caractérisation de nouvelles cibles thérapeutiques.

Thèse soutenue publiquement le 07 avril 2017, devant le jury composé de :

Mme Muriel CORNET

PU-PH, Université Grenoble Alpes, Directrice de thèse

Mr Jérôme GOVIN

Chargé de recherche, INSERM, Directeur de thèse

Mr Frédéric DALLE

PU-PH, Université de Bourgogne, Rapporteur

Mr Nicolas PAPON

Professeur, Université d'Angers, Président

Mme Alix COSTE

Associée de recherche, CHUV Lausanne, Membre

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(27)

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(28)

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(29)

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(30)

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(31)

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(32)

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2 #% %

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(33)

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(34)

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(35)

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(36)

&

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(*. /0!5 -7C33

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(37)

&&

@ # ( 3 , 6 ,2 !" 6 , , # , # $

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(38)

&'

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