The circadian clock regulates RPE-mediated lactate transport via SLC16A1 (MCT1)

We crossed Bmal1KO and Per1–venus mice, and verified that the circadian clock of bulge stem cells and basal interfollicular epidermal cells was arrhythmic, and permanently

Furthermore, LTP amplitude varies with the time of day in mice (Chaudhury et al., 2005), and mice with various clock gene muta- tions show defects in certain types

Rhythmic acetylation of lysine 9 of histone H3 at the Period1 (Per1) and Peri- od2 (Per2) gene promoters is observed with the phase of histone acetylation coinciding with the phase

Circadian rhythm periods as assessed by a chi square periodogram over the 8 consecutive days of constant darkness for mean arterial pressure (MAP, panel A), heart rate (HR, panel

We find that it follows the mRNA expression pattern of mMaoa with a maximum of MAO activity at ZT 6 and a significantly cycling diurnal variation in wild-type mice (p < 0.05,

Since the interaction between CRY2 and CLOCK can only be observed in HER911 cells, and only when using GAL4- CRY2 and CLOCK-VP16 but not with GAL4-CLOCK and CRY2-VP16 (Fig. 2D),

The Per2 gene plays a role in tumor suppression and in DNA damage response by regulating the temporal expression of genes involved in cell cycle regulation, such as c-Myc, Cyclin

(A-D) Circadian expression profiles of Per1 (A, C) and Bmal1 (B, D) mRNAs in the SCN (A, B) and the kidney (B, D) of wild-type (solid line) and rhythmic Per2/Cry1 mutant (dashed