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Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency

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Academic year: 2021

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Fig. 1 CRISPR-Cas9 screen reveals FLCN as an essential gene during the exit from the naïve pluripotent state
Fig. 2 FLCN KO hESC express naïve pluripotency markers. a Schematic representation of FLCN protein and location of CRISPR guide RNAs used
Fig. 3 FLCN is essential for the exit from the naïve pluripotency. a Schematic representation of experimental procedures used to exit naïve pluripotent state.
Fig. 4 FLCN regulates TFE3 subcellular localization in hESC. a Enrichment of transcription factor targets in genes that are up-regulated in FLCN KO 7D TeSR compared to WT 7D TeSR

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