• Aucun résultat trouvé

Applications for a Translational Biomedical Ontology Model

N/A
N/A
Protected

Academic year: 2022

Partager "Applications for a Translational Biomedical Ontology Model"

Copied!
2
0
0

Texte intégral

(1)

!""#$%&'$()*+,(-+&+.-&)*#&'$()&#+

/$(012$%&#+3)'(#(45+6(21#+

!"#$%&'()"*'+%),-$.)'+"/0).$0' 1%-0"/)'2&)&$'3/-4$%5-&6

7+++8)'-(29%'$()+

7/' &8$' 9)5&' &:"' ,$/&;%-$5*' &8$' )<";/&' "=' 5,-$/&-=-,' >$59$,-)..6' <$?-,).@' -/="%<)&-"/' 8)5'

$A9"/$/&-)..6' -/,%$)5$?B' 15' <"%$' #$,)<$'

?-5,"4$%$?*' /$:' 9)%)?-C<5' %$D;-%$?' /"4$.' 4",)#;.)%-$5' )/?' &$%<5B' E8-5' ,%$)&$?' /$:' 59$,-).&-$5' )/?' 5;#59$,-).&-$5' "=' 5,-$/&-5&5' )/?' 8$).&8'9%"=$55-"/).5B'E8$6'#$,)<$'5;#,;.&;%$5' :-&8' ?-==$%$/&' .)/C;)C$5B' F"%' -/5&)/,$*' -/' C$/$%).'<$?-,-/$*'¶-?-"9)&8-,·'<$)/5G';/H/":/' ,);5$I':8-.$'-/'/$;%"."C6*'-&'<$)/5G'9%$5;<$?' C$/$&-,B'

:+++;-(<#10+

2;#J59$,-).-0)&-"/' ,";9.$?' :-&8' &8$' -/;/?)&-"/'

"='?)&)'8)5'#$$/'9%"#.$<)&-,B'F-%5&'&8$',;%%$/&' -/=%)5&%;,&;%$' ?"$5' /"&' &)H$' -/&"' ),,";/&' 5$<)/&-,' 5-<-.)%-&-$5'#$&:$$/' &8$5$' 59$,-).&-$5B'' 2$,"/?*' #$,);5$' )' ,"8$%$/&' 5$<)/&-,' -/=%)J 5&%;,&;%$' -5' <-55-/C*' $A9$%&5' -/' &8"5$' =-$.?5' 5&%;CC.$' &"' )?$D;)&$.6' ;/?$%5&)/?' ?-5$)5$' )/?'

?$=-/$'56/?%"<$5B''E8-5'-5'$59$,-)..6'&8$',)5$'-/' /$;%"."C6B' F"%' -/5&)/,$*' -/=$%$/,$5' <)?$' =%"<' /$:' =-/?-/C5' ,";.?' ,8)/C$' &8$' =;/?)<$/&).' XQGHUVWDQGLQJ RI $O]KLHPHU·V GLVHDVH 7KLV LQ

&;%/' )==$,&5' &8$' H-/?5' "=' D;$5&-"/5' %$5$)%,8$%5' /$$?' &"' )5HB' 1??-&-"/)..6*' &8$' ,%-&$%-)' :-&8' :8-,8' &"' ?$=-/$' 56/?%"<$5' -/' K9-.$956' )%$' 5;#L$,&' &"' ,8)/C$B' E8-5' )==$,&5' &8$' )#-.-&6' ="%' ,.-/-,).' %$5$)%,8$%5' &"' .",)&$' 9)&-$/&5' &8)&' =-&'

&8$-%',%-&$%-)B'7/'"&8$%':"%?5*'&8-5')..',%$)&$5')/' -/$==-,-$/&'5,$/)%-"':8$%$'&""'<;,8'-/="%<)&-"/'

#;-.?5' ;9' )/?' H$$9-/C' ;9' :-&8' &8$' .-&$%)&;%$' 9%"4$5' ?-==-,;.&B' E8;5*' ;/?$%5&)/?-/C' "=' &8$'

?-5$)5$' -5' -/,"<9.$&$*' :8-,8' &8$/' )?4$%5$.6' DIIHFWV D UHVHDUFKHU·V DELOLW\ WR XQLTXHO\

%$5$)%,8' )/' ;/)/5:$%$?' D;$5&-"/' )/?M"%' &"' .",)&$'&8$'%-C8&'5;#L$,&5'="%',.-/-,).'%$5$)%,8B'

=+++/&%>4-(9)2+

E$,8/-D;$5' -/' -/="%<)&-"/' %$&%-$4).' .-H$'

<),8-/$' .$)%/-/C' 8)4$' #$$/' 9%"4$/' &"' #$'

$==$,&-4$' )&' ,.;5&$%-/C' )/?' ,.)55-=6-/C' ?)&)B'' N":$4$%*' :-&8";&' 59$,-=-,' "#L$,&-4$5' "%' %;.$5' 9$%&-/$/&' &"' &8$' ?"<)-/*' &8$' ;5$' "=' <),8-/$' .$)%/-/C' )."/$' 8)5' %;/' -/&"' 4)%-";5' .-<-&)&-"/5' -/' <$?-,-/$B' O/&"."C-$5' :8-,8' 59$,-=6' 8":' ,"/,$9&5' )%$' %$9%$5$/&$?' )%$' )&&$<9&-/C' &"' 5$<)/&-,)..6' 5&)/?)%?-0$' 8":' -/="%<)&-"/' -5' 8)/?.$?')/?'9%"4-?$'%;.$5'="%'&8$',)&$C"%-0)&-"/'

"=' &$%<5' )/?' ?$=-/-/C' &8$-%' %$.)&-"/58-95B' P6' ,"//$,&-/C',"/,$9&5')/?'%$.)&-"/58-95'&"'59$,-=-,' -/5&)/,$5' )/?' -/="%<)&-"/*' )' H/":.$?C$#)5$' -5' -/5&)/&-)&$?' ;5-/C' &8$' "/&"."C6' )5' -&5' 5,8$<)B'' Q8-.$'4)%-";5'#-"."C-,).')/?'<$?-,).'"/&"."C-$5'

$A-5&*'=-/?-/C'&8$',"%%$,&'<)99-/C',"<#-/)&-"/5'

&"' )/5:$%' ,.-/-,).' D;$5&-"/5' -5' 5&-..' )' <)L"%' ,8)..$/C$B'

'

!

?+ ;-("(*&#+

7/' )/' $=="%&' &"' 5".4$' &8-5' ?-.$<<)' "/' 5$4$%).'

=%"/&5*' &8-5' :"%H' 9%"9"5$5' )' &%)/5.)&-"/).'

#-"<$?-,).' "/&"."C6' ="%' 8;<)/' ?-5$)5$B' !)&8$%'

&8)/',.)55-=6-/C':8$%$')'?-5$)5$'/)<$'=-&5'-/')' 8-$%)%,86' >.-H$' <"5&' ?-5$)5$' "/&"."C-$5@*' -&' 9%"4-?$5' )' %"#;5&' "/&"."C-,' -/=%)5&%;,&;%$' :-&8' :8-,8'&"'8$.9'?$=-/$')/6'59$,-=-,'?-5$)5$')/?'-&5' 9%"C%$55-"/'&8%";C8'4)%-";5'5&)&$5'&8)&'?$4$."9'

&8%";C8'&-<$B'1??-&-"/)..6*'-&'?"$5'&8-5'=%"<'&8$' 9$%59$,&-4$'"=')'#)5-,'5,-$/&-5&'&"'<$?-,).'?",&"%'

&"')',.-/-,).'%$5$)%,8$%B'E8;5'-&'9"&$/&-)..6')-?5' ,&%2,QWHUQDWLRQDO&RQIHUHQFHRQ%LRPHGLFDO2QWRORJLHVā%XIIDOR1<86$

'RFWRUDO 3RVW'RFWRUDO&RQVRUWLXP-XO\

(2)

!"#$%&'()*+(!*%),$-).#&/!().*)',$().$!&()/0#&$%0$

*)0%&1(!*%)$0&%1$2#)3"$!%$2#./*.#$().$2(345$

!" #$%%&'(")%*+&,(-"

6)$ %)#$ -/#$ 3(/#,$ 7(&!$ %0$ !"#$ %)!%8%'9$ */$ 2#*)'$

-/#.$ %)$ ($ 3%&7-/$ !%$ !&(*)$ ().$ !#/!$ ($ 1(3"*)#$

8#(&)*)'$ (8'%&*!"1$ !"(!$ &#3%')*+#/$ ().$

/#1()!*3(889$ !('/$ /#)!#)3#/$ *)$ /3*#)!*0*3$ ().$

PHGLFDO WH[W DERXW $O]KHLPHU·V 'LVHDVH 7KH 7-&7%/#$ %0$ !"*/$ */$ !%$ 2-*8.$ ()$ (8'%&*!"1$ 0%&$ ($

/9/!#1$ !"(!$ (-!%1(!*3(889$ -7.(!#/$ *!/$ %:)$

4)%:8#.'#2(/#5$ 6!$ 3()$ /3()$ /#)!#)3#/$ ().$

(-!%1(!*3(889$ 38(//*09$ *)0%&1(!*%)$ (2%-!$ ($

.*/#(/#$ ().$ !"-/$ -7.(!#$ !"(!$ *)0%&1(!*%)$ *)$ ($

4)%:8#.'#2(/#5$ ;"#$ '&%:*)'$ 4)%:8#.'#2(/#$ */$

!"#)$-/#.$(/$!"#$!&(*)*)'$().$!#/!*)'$3%&7-/$().$

"#87/$ !%$0-&!"#&$&#0*)#$ !"#$(8'%&*!"1$0%&$0-!-&#$

/3()/5$ ;"#$ 4)%:8#.'#2(/#$ (8/%$ /#&<#/$ (/$ ($

/#1()!*3(889$ /#(&3"(28#$ .(!(2(/#$ !"(!$ 3()$ 2#$

0*8!#&#.$ 0%&$ *)0%&1(!*%)$ !"(!$ ()/:#&/$ ($ /7#3*0*3$

=-#/!*%)$%&$"#87/$/%1#%)#$!%$2#!!#&$-).#&/!().$

!"#$.*/#(/#$%&$!"#$.*&#3!*%)$!"(!$0-!-&#$&#/#(&3"$

1-/!$!(4#5$$$

6)$ ()%!"#&$ -/#$ 3(/#,$ !"#$ !#&1/$ ().$

&#8(!*%)/"*7/$ 7&#/#)!$ *)$ !"#$ %)!%8%'9$ *!/#80$ (&#$

3-&&#)!89$ 2#*)'$ #>78%&#.$ *)$ !"#$ .#0*)*!*%)$ %0$

?7*8#7!*3$/#*+-&#/$().$/9).&%1#/5$;"*/$*/$!%$2#$

-/#.$:*!"$38*)*3(8$.(!($*)$*@2@$0%&$!"#$7-&7%/#$%0$

*.#)!*09*)'$ /-2A#3!/$ 0%&$ 38*)*3(8$ /!-.*#/$ ().$

!&*(8/5$6)0%&1(!*%)$'(!"#&#.$(!$!"*/$/!('#$:*88$2#$

1*)#.,$ /#1()!*3(889$ !(''#.,$ ().$ (..#.$ !%$ !"#$

4)%:8#.'#2(/#5$$;"*/$:*88$(..$!%$!"#$3%&7-/$-/#.$

!%$ !"#$ 1(3"*)#$ 8#(&)*)'$ 1%.#8$ ().$ "%7#0-889$

&#/-8!$*)$1%&#$(33-&(!#$!(''*)'$:"*3"$:*88$8#(.$

!%$2#!!#&$-).#&/!().*)'5$

." /&(0*1-"

B/$ ($ 0*&/!$ /!#7$ !%:(&./$ 7&%<*)'$ !"*/,$ #00%&!/$ !%$

(-!%1(!*3(889$7%7-8(!#$*)/!()3#/$:#&#$7-&/-#.5$

;"#$ %)!%8%'9$ :(/$ -/#.$ *)$ ($ 1(3"*)#$ 8#(&)*)'$

38(//*0*#&$!%$/#1()!*3(889$!('$/#)!#)3#/$(-!%1(!C

*3(8895$ 6)$ !"*/$ 7&%A#3!,$ %<#&$ DEEE$ .*/#(/#/$ :#&#$

1()-(889$ &#<*#:#.$ ().$ /#1()!*3(889$ !(''#.5$

F(!#'%&*#/$ !"(!$ .#0*)#$ .*/#(/#$ *)$ !"#$ %)!%8%'9$

:#&#$ 3"%/#)$ !%$ 2#$ !"#$ /#1()!*3$ !('/G$ ?!*%8%'9,$

?7*.#1*%8%'9,$ F8*)*3(8,$ H*(')%/*/$ I;#/!/J,$

K&#<#)!*%),$ ;&#(!1#)!,$ ().$ K&%')%/*/5$ L%&$ !"#$

7-&7%/#$%0$!"*/$#>7#&*1#)!,$/#)!#)3#/$7#&!(*)*)'$

WR$O]KHLPHU·VGLVHDVHLQ+DUULVRQ·VDQG&HFLO·V 7H[WERRNV RI ,QWHUQDO 0HGLFLQH DQG 5REELQ·V K(!"%8%'9$:#&#$1()-(889$3-&(!#.$().$!(''#.$!%$

7&%.-3#$($3%&7-/5$B$7&%'&(1$:(/$3&#(!#.$!%$.%$($

DE>DE$ 3&%//$ <(8*.(!*%)$ %0$ !"#$ 3%&7-/$ -/*)'$

M-77%&!$N#3!%&$O(3"*)#$().$P%'*/!*3$Q#'&#//*%)$

38(//*0*#&/$*)$R?SB$!%$!#/!$().$!&(*)$($1%.#8$0%&$

(-!%1(!*3$38(//*0*3(!*%)5$$

2" 3&-$4(-"

;"#$ #>7#&*1#)!$ */$ %)'%*)'$ ().$ &#/-8!/$

7&#8*1*)(&95$ K&#3*/*%),$ &#3(88,$ ().$ 0C1#(/-&#$ %0$

!"#$1%.#8$*).*3(!#$"*'"$7&#3*/*%)$ITUCDEEVJ$().$

8%:$&#3(88$IWC@EVJ$:"*3"$(.<#&/#89$(00#3!/$!"#$0C 1#(/-&#5$;"#$8%:$&#3(88$3()$2#$*17&%<#.$29$!"#$

&#1%<(8$ %0$ /!%7$ :%&./,$ /!#11*)',$ (..*)'$ 1%&#$

!(''#.$ /#)!#)3#/$ !%$ !"#$ 3%&7-/5$ K#&"(7/$ (3!*<#$

8#(&)*)',$ %&$ *)38-.*)'$ "-1()$ 0##.2(34$ *)$ !"#$

7&%3#//,$1(9$*17&%<#$&#/-8!/5$B88$%0$!"#/#$3()$2#$

(!!#17!#.$ !%$ 1(>*1*+#$ 0C1#(/-&#5$ X*<#)$ !"(!$

38*)*3(8$ !#>!$ !#)./$ !%$ 0%3-/$ %)$ .*/3-//*)'$

#7*.#1*%8%'9,$ 38*)*3(8$ /*')/$ ().$ /917!%1/,$

.*(')%/!*3$ !#/!/$ ().$ 7&%3#.-&#/,$ ().$ 7&%')%/*/$

%0$.*/#(/#$1%&#$!"()$#!*%8%'9,$*!$*/$)%!$/-&7&*/*)'$

!"(!$#!*%8%'9$"(.$!"#$8%:#/!$7&#3*/*%)5$;"*/$1(9$

2#$ *17&%<#.$ 0-&!"#&$ 29$ (..*)'$ 1%&#$ 2(/*3$

/3*#)3#$!#>!$*)!%$!"#$3%&7-/5$

5" #*',4$-6*'"

;"#$ "*'"$ 7&#3*/*%)$ *).*3(!#/$ !"(!$ :"*8#$ 1-3"$

:%&4$/!*88$)##./$!%$2#$.%)#$!%$*17&%<#$&#3(88,$!"#$

-/#$%0$8#(&)*)'$(8'%&*!"1/$!%$(-!%1(!*3(889$!('$

%)!%8%'9$!#&1/$*/$($<*(28#$7&%3#//5$;"*/$7&%<*.#/$

!"#$1#()/$!%$0%&1(8*+#$($.*00*3-8!$7&%28#1$!"(!$

)##./$0-&!"#&$!#/!*)'5$;"#$)#>!$/!#7$*/$!%$#>7().$

!"#$ -/#$ %0$ !"#$ %!"#&$ /#1()!*3$ !#&1/$ ().$ !%$

.#!#&1*)#$*0$!"#$!(''#.$/#)!#)3#/$0&%1$!"#/#$(&#$

(28#$ !%$ 2#$ /#(&3"#.$ 0%&$ ()/:#&/$ !%$ 2*%1#.*3(8$

=-#/!*%)/5

$

!"#$%$&'( !)#*+,#$%$&'( -%#.#/0%( 1#0&.$2#2( 34+5+."#$.( 64+0",+."( 34$&.$2#2(

789( :;( 789( :;( 789( :;( 789( :;( 789( :;( 789( :;( 789( :;(

Precision <=>( <?>( @A>( @<>( @<>( @<>( @B>( @C>( CDD>( @@>( @@>( @C>( @B>( @@>(

Recall BD>( BD>( CC>( CC>( CE>( CC>( BC>( BC>( F>( F>( =>( <>( CB>( CB>(

F-measure EB>( EB>( C@>( BD>( BB>( BD>( EF>( EA>( <>( @>( CB>( CF>( BB>( BB>(

Références

Documents relatifs

Here we report on the usage of patterns applied to two biomedical ontolo- gies: firstly a novel ontology for karyotypes which has been built ground- up using a pattern based

With well-established ontologies now availa- ble in the OBO community, we are able to adapt the EFO approach to build the Beta Cell Genomics Ontology (BCGO) by

In order to produce our maturity model for biomedical data curation, we reviewed the literature of biomedical data curation in the last five years, and the literature on

For external evaluation, other metrics can be useful to provide a quantitative overview, such as number of classes, properties in the ontology, or number of projects

2 illustrates an example design of how EGO represents ChiP-seq read results for human Forkhead TF FOXM1 binding in the cell line cell U2OS, which occurs at

On this basis, a curriculum of 16 modules was developed to train students in the biomedical domain with a back- ground in computer sciences how to practically develop and

The CORE problem list subset of SNOMED CT [6] was used as signature in the domain of diseases to find related drugs in RxNorm, using NDF-RT as a cross-ontology, and the

[r]