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Combinatorial drug discovery in nanoliter droplets

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Academic year: 2021

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Fig. 1. Droplets platform for combinatorial drug screening. (A) Compounds, cells, and encoding dyes are emulsified into nanoliter droplets and subsequently pooled
Fig. 2. Characterization of droplet platform performance. (A) To model cross-contamination, we tracked the exchange of the fluorescent dye resorufin (carried by source droplets) to empty droplets (sink droplets, encoded by fluorescein)
Fig. 3. Drug repurposing antibiotic potentiation screen. (A) To measure antibiotic potentiation, we generated three-point dose-response curves for 10 different antibiotics in combination (SI Appendix, Table S1) with 4,160 compounds (each at single concentr
Fig. 4. Validation of hits from primary screen. (A) In eight-point checkerboard assays with E

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