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Supplemental Table S1: Comparison between Kdn and Kdo*

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Supplemental Table S1: Comparison between Kdn and Kdo*

(*Based on multiple references mentioned in the text)

Kdn Kdo

Backbone 9-carbon 8-carbon

Occurrence All vertebrates, some bacteria,

algae All Gram-negative bacteria, some algae, most higher plants Structure

Glycosidic linkage a a and b

Biosynthetic pathway Condensation of Mannose-6-P

and PEP Condensation of Arabinose-5- P and PEP

Presence in human glycome Yes No

Synthesis by bacteria Yes, also assimilated from

environment (this study) Yes, Conserved pathway in Gram-negative bacteria Presence of recognizing

antibody in human Yes

(this study) Unknown

Functionality in bacteria Structural (?)

Immune evasion (this study) Component of some capsular polysaccharides and core

component of lipopolysaccharides

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