Département des Sciences Naturelles
: ! "
#
$ % &
:
)
( ) *
( ...
… .. .
/ " ) ... (
...
" …
) :
( ) *
( ...
… ..
"
* ) ( ...
… 0 .
# 1" # 2
3
4 5 5 4 5. 25! –
Ministère de l’Enseignement
Supérieure et de la Recherche Scientifique
ECOLE NORMALE SUPERIEURE VIEUX KOUBA (ALGER)
Rutine
Cytarabine
Balb-C
...
1
-I ...
2
-1-1 ...
...
2
-1-1-1 ...
3.
-2-1-1 ...
3
-2-1 ...
...
5
-1-2-1 1
... G 5
-2-2-1 ... G2
5
-2-1 -3
... M ...
5
... -3-1 6
-1 4 ... -
8
-1-4-1 ...
...
8
-2-4-1 ...
8
-1-2-4-1 ...
10
-2-2-4-1
!
...
10
-3-2-4-1
" #
caspase ...
. 10
" " -5-1 ...
11
-1-5-1 ... $
11
-1-1-5-1
%
&
...
11
-2-1-5-1
' %
...
11
-2-5-1
" ( )
...
12
-1-2-5-1
* +
...
...
12
-2-2-5-1 "
...
13
-3-5-1 ... # ,
13
-1-3-5-1 ... # ,
...
13
-2-3-5-1
- # ,
...
15
-4-5-1
"
...
17
-1-4-5-1 ... .
...
17
-2-4-5-1 %
.../ -0 17
-3-4-5-1 ...#'
18
-5-5-1
" "
...
...
18
-6-5-1
" 1!
...
19
-1-6-5-1 - 1!,
...
19
-2-6-5-1 ,&+ 1!,
...
...
19
-3-6-5-1 2 1!,
...
19
-4-6-5-1
34 1!,
...
20
-5-6-5-1
3 1!,
...
...
20
-6-6-5-1
3' 1!,
...
20
!" # $%
-II. ...
22
5 , -1-2 ...
2 2
6 -2-2
"
...
2 2
-1-2-2
0 6
...7!
2 3
-1-1-2-2
0 8 6
...
... 3 2
-2-1-2-2 ... ' 9
3 2
-3-1-2-2 ... ' 9
4 2
-2-2-2
: ) 4; # ,
... ADN 24
-1-2-2-2 ... <
...
24
-2-2-2-2 ... 6
25
-3-2-2
5' 9 : 4;
...
25
-1-3-2-2 ... ,
...
25
Les épipodophyllotoxines -2-3-2-2 ...
26
-4-2-2
= Cytarabine ...
26
-1-4-2-2
# , 0 ...
...
27
-2-4-2-2 ...# ,
27
-3-4-2-2 7!
= Cytarabine ...
27
-4-4-2-2
> 0 , ...
...
28
-5-2-2
3' 1!, * - 4<
...
28
-1-5-2-2
# * - 4<
= Cytarabine ...
29
-2 2 - 6
= ? -
Cytarabine ...
30
&%
-III...
31
-1-3 5 ,
...
31
-2-3 ...
31
-3-3 ....5 *
...
33
@ @ -4-3 ...
34
-1-4-3 ...@
34
-2-4-3 ...@
...
34
-5-3
A!8 B
...
34
A!8 7! -6-3 ...
35
-7-3
' 8 $' *
... ' 36
-8-3
0 * - $' *
...
36
-9-3
= Rutine ...
37
!
' (" -I (
-1-1 ...#
39
1 - 2 ... -
39
1 - 3
# , - ...
39...
1 - 3 - 1
= '! - " , - Cytarabine
...
39
-2-3-1
# , " '8 @ ...
40
-3-3-1
% * ...FNS
41
-4-1
3' * #
...
41
-II
)* +"
...
41
2 - 1
= - Cytarabine
2 CB D -
" . 2 ...
...
41
2 - 2
= - Cytarabine
B 6 D -
...
47
2 - 3 - - ...
49
...
...
51
...
52
$
1
!
"#
" % & ' ( ) * .
+
, - , - !. / 0 * 1 +2 3
4 5 6! .
5 * 738 !
"
,6: ,6: !. 6
;< 6 # ....
;- =% 4 ."
& ' > : ?!) 5
/1
, 6 5
) .
A ! # B " > , 3 ,C * 4 . # B
6 <
! "# D # E * , 6% " "
- 6 2" ) .
- 6 2" ,C
" " F
, 3 " 6 5
.
6 # G/ G !) 1
& # / 4 . . EH
5 " * * * & ' > : + "
.
EI ?!) J & # 1 4 K & ' (
& ' 0 , +
D # < +1 / 6 5 - !L
"= 4
.
) "= M & # 0 <
Rutine
6
- 6 2" % . EH = , " ; 8
N Cytarabine & #
M H
.Balb-C