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Transportin-1: A Nuclear Import Receptor with Moonlighting Functions

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Academic year: 2021

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FIGURE 1 | Structural organization of Transportin-1. (A) Trn1 is composed of 20 HEAT repeats and adopts a superhelical architecture [free Trn1: PDB code 2QMR (Cansizoglu and Chook, 2007)]
TABLE 1 | Crystal structures of Transportin-1.
FIGURE 2 | Nuclear import cycle of Transportin-1. (step 1) Trn1 associates with its cargo via the NLS in the cytoplasm [free Trn1 in gray: PDB code 2QMR (Cansizoglu and Chook, 2007); hnRNP A1 cargo with its unstructured ‘ M9 ’ NLS in purple: PDB code 2LYV
FIGURE 3 | PY-NLS recognition by Transportin-1. (A) A common binding site for PY-NLSs with the C-terminal arch of Trn1
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