Comparison of the effects of low childhood socioeconomic position and low adulthood socioeconomic position on self rated health in four European studies.
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Texte intégral
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(113) f V @P'FVWGW
(114) F `*z ];dWxGH =+;(>2@,WA;P@^dHFCM d+@,Ag2;k>2VjH = ?d W
(115) UUKMGxG;>2@,WA];AF]UWGFHF];UU%W=+F*@ A*E> W>2VH z = @,U L d+WA WP,F$>2VW= xGH0; AjFO W=> HK=+U;= =+H = W] z 7"U PR;$dKd+@,g @'U;k> @,WAOX Y7WP,P,W
(116) ]@,A*]p0M/AGd?> ; AjF U%W
(117) P, P'H; *MH*d+
(118) l tH0F@d2> @,A*M/@^d+VH%F V@,
(119) Vt; AF]P, W `*z = W*MGx
(120) d X I wiH$d xGWAFHA$>+d OVW/d+H0g2;k>2VH=oVj;FCNGHHA H@r>2VH= z 6 UP;d(+d l RBt@1GV ` H =?ZG@'UH 'l
(121) W*=jl n
(122) W ` H =^ZG@'UH
(123) l tH =+H0UWGFHFE;$d V; ZG@,A V@,GV `*z @,A U V@'PFVWGWGF*
(124) l EV@,P^d?>7=+H$d xGWAjFH A$>+d EVjW dHg2;k>2VjH =V;%FtNGHH A]@,A z i UP,;*d(d l wiWjM>2@,AH6AjWAj a;AM;TP l
(125) ~l :S;A$M;Pd2MGxGH =?ZG@^d+W=(d l/}l ` L
(126) @,P,P'HF a];A$M;P lGl ` Ha]@'W= MGA
(127) d LG@,PP'HF]a;AM;TP W+ = *l Y7; =+a P; NWjMG=+H= l tH =+H0UWGFHFE;$d V; ZG@,A Vj;F PR W UTV@,P'FVWGW
(128) F `$zi` VW
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(130) >2VjH@=og2;K>2VH =VG;FCNHHA d+HP,g Ha xGP,WDHFl
(131) @^¢H*g^=+W
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(133) a>2VjH$d+H0;A;P,D/d+H*dT ; =^>2@'UT@ x/;A$>+d /
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(135) F `$z " 0G;@1A >2VHCd+HP'g2 Ha xGP,WDH!F ]H=+H0(H GUPMFHF/ q AC>2V=+HH0Wg/>2VHCd?>^MF*@RH$dd+HP'g2?=+;k> HFEVjH;Pr> V ];$d"a H;$d2MG=HFCM d+@1A ;C?xGW@,A>odU;P,H0g^=+W
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(137) FCVjH;Pr>2V] U%W
(138) aEx=+@^d+@1AE>2VH0g?@,=(d2>/>2V*=+H%H =+H$d xGWAGd+H$d ";AFExGWW=7VH;Pr>2Vt UW
(139) aEx=+@^d+@,AE>2VH0P,;$d?>> ]WE=+H$d xGWAGd+H$d K q AC>2VH0+ z n d2>^MFjDjl/d+HP,g =+;k> H%FCVH;Pr> !V t;$d"a]H;$d?MG=HF]WA];A}?xGW@1A>"d+U;P,HlG;AFC>2VH0P,
(140) W ]Hd?>/>2V@=F Wg/>2VH0F@d?>2= @RNM> @RW!A t;$d UWA
(141) d+@'FH =+H%F ;dxGWW=7VH;Pr>2V*VH0F@^d?>2= @NM> @,WA/d"Wg7U V@P F*VWGW
(142) F `*z 7lG;F$MGPr>2VWGWGF `$z ; AjFExWW=VH;Pr>2V @,A H;UV]Wg >2VjHCd+;a]x
(143) P'H$d ; =+H6x=+H$dHA$> HFE@,AC> ;kNGP'H . . HAL author manuscript. inserm-00108382, version 1. A;P1DdH$d. V*=+HH0P,W
(144) @'d?> @,U6=+H =+Hd(d+@,W
(145) A]a]WGFHP^d ]H=+H0UWA
(146) d?>2=2MU> HF0>2W> H$d2>
(147) >2VjH0Hg?g HUk>+d"Wg[PRW `jz @,A]U V@'PFVWGWGF ; AjF @,A];F$MPr> VWGW
(148) FEWAExjWW="d+HP,g2?=+;k> HFEVjH;Pr> V]@,A];F$MPr>2VjW
(149) WGF
(150) q A0>2VH6g2@1=d?>atW
(151) FHPG a]WGFHTP q WAPRD U V@'PFVWGWGF `*z t;$d@,AUPMFHF/ q AC>2VjHCd+HUWAF]a]WGFHTP a]WGFHTP q q WA*PD ;F$MPr> `*z $ t;$d@,AUPMFHF/ q A >2VH>2V@=+F]a]W
(152) FHPG a]WGFHP q q q [NW$>2V]U V@,P'FVjW
(153) WGF]; AF];F$MGPr> VWGWGF `*z tH =+H6@AGUPrMFGHFC>2WGH(>2VH =K 0A;P,DG d+Hd ]H=+H0U; = =+@,H%F W*M*>"dH xG; =+;(> H PD g2W="a]HA];A!F tWa]HAjljM d+@,A* H@r> VH =[>2VjH ` > ;(>2@d2> @RU;P*;U LG;GHg2W= ` W
(154) U@,;P ` U@'HAGUH$d" ` ` ` W= ` > ;(>2@d2> @,U%;TP CAj;TP,D/d+@^d ` D/d?> Ha ` ` K /!' 9
(155) '*)+& - 0
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(158) U V@'P'FVjW
(159) WGF `$zi` | ~
(160) }G¢~ P,W
(161) ;F$MPr>2VjW
(162) WGF `$zi` G |
(163) }G¢ /}Gr |* ¢~ xWW=odHP1g7;*d(dH*d(d+H%F VH%;TP¢> V ¢ R} K ¢|. 5.
(164) (./!, . HAL author manuscript inserm-00108382, version 1. 7Y W=a]HAlG@1A >2VH0aCM>^M;P1P,D];%F M7d?> HF]; Aj;TP,D/dHjdl
(165) UV@P'FVGWWGF `*z ];$d =+H P,;k> H%FO>WExWW=od+HP,g =+;k> H%FCVH;Pr> V]@,AFH xGHAFHA> PD Wg7;F$M/P¢> `*z =H P,;k> HF0>2Wd+HP,g 2=+;k> HFEVH%;TP¢>2V @,AEY =+;AjUH0 \6w G*+lGCHK=+ a ;A*D \6 w ¢|*"; AjF>2VH y Hk>2VH=8PR;TAjF d \iw 2;kNGP'H6+
(166) l EVjH =+H;$d"g2W= ]Wa]HAC>2V@d ];*d[>2VjH U;$dH@,A z A*GP';AGF \iw ¢~
(167) ; AjFO>2VjH y HK>2VH = P';AF
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(169) P';AF] \6 w ¢|+l
(170) H = at;TA*Dt \6 w ¢|*"; AjFC>2VH y Hk>2VH =+P,;AjF
(171) d \6 w ¢|
(172) }7g2W= OWa]HA/Y7W=[Y =+H AjUTV ]Wa HTAOAH@r> VH ="U V@'P'FVjW
(173) WGFCAW=";F$MGPr>2VjW
(174) WGF `$z $ ]H =H =+H PR;k> HF >2WdHTP,g2?=;k> HFEVH;Pr> V] ";kNGP'H K /!G9*t((% *+ ' ?#t(!12) *&- s *!,+ &!'$# % ,!'& & &3 &./!,"(% *) 0 ( ,+ 9& & * & / & 0 ' *! (9 & ! ' % ,!'& &
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(179) E+ !' & G9. 9 *) 9 . 9 9 *) 9 G9 G9 *) 9 G9 9 *) 9 I*o:W
(180) FHP q
(181) P,
(182) W UV@1P'FVWGW
(183) F `z0` Z/dV@
(184) V UV@P'FVjW
(185) WF `*zi` , Q o: WGFH P q q
(186) PR W ;F$MPr>2VWWGF `$zi` ZdK V@,
(187) V ;F$MPr> VWGW
(188) F `*z0` ,X/:<WGFHP q q q q ;AF q q l/aCM>^M;PP1D ; F M[d2> HF/$Y7@*MG=+H*d @1A !'& ; =H d+@,
(189) A@'g?@'U;A$> ;k>/>2Vj"H !$# r
(190) iP,H ZHTP . 6.
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(195) K /} / G2/* /} / G2/ G* /¢* /r~
(196) K & ¢* /r~~ K /¢| / G ¢|* /r
(197) }2/¢ . 9 9 *) 9 E+ !' &. 9 9 *) 9 . 9 9 *) 9 G9 9 *) 9 . 9 9 *) 9 I o:W
(198) FHP q
(199) P,
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(201) F `z0` Z/dV@
(202) V UV@P'FVjW
(203) WF `*zi` ,
(204) Q"o: WGFH P q q
(205) PR W ;F$MPr>2VWWGF `$zi` ZdK V@,
(206) V ;F$MPr> VWGW
(207) F `*z0` ,X/:<WGFHP q q q q ;AF q q l/aCM>^M;PP1D ; F M[d2> HF/$Y7@*MG=+H*d @1A !'& ; =H d+@,
(208) A@'g?@'U;A$> ;k>/>2Vj"H !$# r
(209) iP,H ZHTP . HAL author manuscript inserm-00108382, version 1. . (%.( '. VH6xGH =d+@d2> H AU%H0Wgd+WGU@,WG HUWAWa]@U0@,AGH $M;P@r> @'H$d ]@¢> V@,A]a ;TA*D z MG=+WxGH; AtUWjMGA>2= @,H$dl
(210) FH% d xG@r> H0W*ZGH =;TP,PG@a]x=+W*ZGHa HA$>+d"@,AExGWx*MGPR;k> @RWAEVGH%;TP¢> VjlVG;$d"P,H%F a ;A*DE=+H*dH; =+UVH=(d";AFExGWP1@'U D a ; LGH =(d >2W];FWx$>;6P1@,g HUW*MG=(d+H6xGH=(d xGHUK> @ZGH >WtNHk>> H = MGAFH =d?> ;KAF];AFC> ;U LP'H >2VHd+H0@1Aj H $M;P@r> @'H*dKB]W
(211) ]HKZGH =+l >2WOWjMG=LAj W OP,HF*GHl*>2VH=+H6V;kZH NHHTAOAWU= W/d(d?A;k> @,WAG;PGUW
(212) aExG; =+@^d+WA
(213) d Wg/>2VH6=HTPR;k> @RWA/d+V@,xENGHk> tHHA P,
(214) W UV@,P'FVjW
(215) WGF]; AFEP,
(216) W ;F$MPr>2VjW
(217) WGF `*z WAOVH;Pr> V]P,; > H =[@,A]P,@g H* q AC>2VH0;kN dHAUH0Wgd?MUV];Cd?>^MF*Djl tH0;k>> H aOx*> HF>2W H xGP,W=+Hv>2VjH$d+H6x=W
(218) UHd(d+Hdo@,A]g2W*MG=" H G@?d2>2@1AAj;k> @RWAj;TP d+;a]xGPHd NDtV; =+a]W
(219) A@^d+@,A WjMG= =+H$d xGHUk>2@ZH0a]H;*d?MG=+Hd"Wg `*z ; AjFd+HP,g ?=;k> HFEVH;Pr>2V f WA$>2=+;=?DC>W]WjMj=V*D*xGW*>2VHd+H$dl
(220) P,
(221) W `*z0` F$MG= @1A NGW*>2VExGH = @,W
(222) F
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(224) U@,;k> H%F O@r>2VExGWGW*=VH%;TP¢>2VC>2V;A]U V@'P'FVjW
(225) WGF]U @=+UkMa3d?> ; AjUH*dK VH$dHg2@,AGF@,A d"; =+H0U%WAGd+@d2> H A$> O@r>2V]W$>2VjH =d?>^MF*@,H*d[>2Vj;k>d V
(226) W ZG;=8@R;k> @RWA]@,AC>2VH0(H > H A$> ; AjF a ; GA@r>^MFH0WgdW
(227) U@,;P/@,AG H $M;P@¢> @'H$d"@,A]VH;Pr> V];U =W ddo@,AGF$M d2>2= @,;P@ u HF]UW*MGA$>2= @HdQK V@d"a ; DENGH%l
(228) @,A xG; =?>ljNHU;kM dH >2VH0F@d?>2=+@N*M> @,WA
(229) d"Wg[VjH;Pr> V]; AFE=+@^d L g2;$UK>2W=(d[ZG;=Dtg^=+Wa U%WjMGA>2=?DC> W]UWjMGA>2=?Djl
(230) ;AF @¢> V;*d[NHHTA d?MGGH$d2> HFC>2V;k>G>2VHCd xGHU@1g @U0FHK> H = a]@,AG;TA>+d"W*g[@,AG H $M;P'@r> @'H*d"a]; D AW*>/NGH0@,FHA$> @,U;PG@1A H;%UTV A;K> @,WA X TBO
(231) W ]HKZGH =+l@r>7@^d"@1A> H =+H$d2>2@,A*E>2V;k>>2VH ZG;=8@';k>2@'WAE@,AC>2VH0a ; GA@r>^MFH0Wg/>2VjHCd+@
(232) A@'g?@'U;A$> ;$dd+WG U@,;k> @,WA
(233) dd+Vj W tHFEGH AFGH ="F@,g?g H =+HAU%HjdTYW= OWa]HAl
(234) @,A UW*MGA$> = @,H*d OVGH =+H `*z @d";d(d+WGU@';k> H!F E@¢>2V xGWW=[VH%;TP¢>2V] z A*GP;AjFl y Hk>2VH=8PR;TAjF d ; AF] H =+a;A*D+l*>2VH =H ];$d ;6=+H P,;k> @ZGH0VW
(235) atWGH AjH@r>?DtW
(236) g/>2VH . 7.
(237) HAL author manuscript inserm-00108382, version 1. ?d >2=H A**>2V]Wg/>2VH0;$dd+WGU @';k>2@,WA/B]W
(238) tHkZGH =lg2W=a]HAC>2VHCd >2=H A**>2VOWg7;$dd+WGU@;K>2@,WA/d d+VW
(239) ]HFEa]W=+H Z; =+@;% >2@,WA/ q A];FF@r> @,WAl*>2VH6=+H$d2MGPr>+d=+HKZGH;P
(240) @,A$> H=+H$d?> @,A*]AG;k>2@,WA;PF@,g g H =+HAjUH*do@,AC>2VjH6GH AFH=+HFExG;k>^> H = AOWg ;$dd+WGUT@R;k> @RWA/d q A> H =+H$d^>2@,A*GP1D AjHT@¢> VjH =oPR W `jz @,A]UV@P'FVWGW
(241) FCAjW=@,A];%F$M/Pr>2VjW
(242) WGF t;$d";$dd+WGU@,;k> H!F ]@r>2V xGWW=[VH%;TP¢>2V g2W= tWa]HA]@,AC>2VH Y =+HAUVd+;a]xGPHTBt W OHKZGH =[>2V@^d"@^do@,A]P,@,AGH ]@r> V]W$>2VH ==H$d+H;=+U V ;a]WA* ]WGa]HA @,AC>2VjH0 z n d2>^MFjD X (V@^d"UW*MGP,Fl
(243) @,AExG; =2> ljNH0F$MHv>2W0>2VH0g2;Uk>/>2Vj;k>/>2VH OWa HA @,AC>2VH6Y =+HAjUTV d?>^MF*D]; =H0F*=+ ; OA g^=Wa ;A]WGUUkMGxG;k>2@RWAj;TPUWVW=> OV@,Pd2>/>2VW/d+H6@,AC>2VjH0W$>2VH ="U%WjMGA>^=?D d?>^MF*@RHjd ; =+H6GH AjH =+;PxGWx*MP';k>2@,WAd+;a]xGPH*d MH >2W>2VjH6A;k>^MG=H6Wg >2VjHCd?>^MF$Djl*>2VH =+H0;=+Hv> OW]a]Hk>2VWGFWP,WG@,U;PUWA
(244) d+@'FH =+;k> @,WA
(245) d[>2Vj;k>7AHH%F >2WCNH > ; LGH A]@,A$> W];UUW*MGA$> VjH =+H0; =H6@dKd?MH*d[>2Vj;k> ;k=+H0UWa atW
(246) AC>2W ; P,P
(247) P'@g HUW*MG=(d+HCd2>^MF*@,H*d"; AjF W*>2VH= @^dKd?MH$d7>2V;k> ; =+H0UWa atW
(248) AC>2W ; P,PGU =+W/d(dAj;k> @,WAj;Pd2>^MF*@H*d*\6MG=a]H;$d2MG=+H*d"Wg[UV@,P'FVjW
(249) WGF `$z =+H P,@'HF MGxGWAE=+H(>2= W/d xGHUK>2@rZH6=+HU;P,P ]V@'UTV]a]; D]NGH0@,a]x/H =+g2HUK>[X q >7@d=+H;d(d?MG=+@,AGl*>2VH Ajlj>2Vj;k>"d>^MF*@RH$d"UWA F$MUk> HFE@,AC>2VjH mEA@r> H%FOpO@,AGFW
(250) a ;AF]@1A >2VH mOA@r> HF ` > ;k> H$dd V
(251) W >2Vj;k>7a]Ha]W=8@RHjd Wg xG;$d2>odW
(252) U@,W
(253) H%UW
(254) AWGa @'U0U@=+UKM/a3d?> ;AjUH*d[> H AFC>WONH6=+H P,@'; NGPH _ _ I y WAHk>2VjHP,H*d(d+lxG; =?>2@RUT@,xG;A$>+d ]@r>2VC>2VjHa]W/d?>F*@d;F ZG;A> ; GHF]U@=+UkMa3d?> ; AjU$Hdoa ; D]Vj;%ZH0g2;@P'HFC>2WE=+HxGW*=>/>'VjHT@,="g2;k>2VH= ?d"WGUUkMGxG;k>2@RWA jg2W=@,A
(255) d2> ; AUH > H A xGH ="UHA$>7Wg/>2VH Y =+HAGUTV d+;a]x
(256) P'H0F@,F AjW$>[@,AjF@'U;k> H >2VjH@=g2;k>2VH= ^d +WNl
(257) ; AjFd+@1AGU%H >2VH !D tH =+H0a]W=+H P@,LGHP1D > WE=+H xGW*=^>7xWW*=VH%;TP¢>2V] F;k> ;0;kZ;@1P'; NGP'H0WAO=+ H $MH$d2>2>2V*@^d"F;K> ; ];$d x= W*NG;kNGP,D AW$>7a]@dKd+@,A ;k> =+; AjFW
(258) a3\iZH =+;PPRl
(259) ;A*D]a @dUP';$dKd+@,g @'U;k> @,WA]Wg[UV@'PFVWGWF `*z @d"P'@1LGHP,DC> W]V;kZHiNG@';$dHF]WjMG==+Hd?MGPr>+d >2
(260) W t; =+F
(261) d >2VH6A$MP,P2 AW*>2VH =xjW$> H A$>2@R;TPP@,a@r> ;K> @,WA]@^d[>2V;k>WjMG="d+;aExGPHd ]H=+H0F*@,g g H =+HA>%>2V=+HH tH =+H NG;d+HF]WAC>2VH GH AjH =+;P
(262) xGWx*MGP';k>2@,WA] z A*GP';TAjFl y Hk>2VjH =+P,;AF/d"; AF] H =+a ;TA*Dj EV@'P'H0WAjH@,AGUPrMFGHF]WAPD tW= L@1A a HA];A!F ]Wa]HA]Y =+;AUH K V=+HHsWg7W*MG=d>^MF*@RH$d tHT=H6A;k>2@,WA;P z A*GP;AjFl
(263) H =+a];A*D ;AF Y =+;AjUH +
(264) l EV@'P'H0WAjH ];$d7NG;*d+HF]@,AC>2VH0; =H;0Wg7;0P,; = GH U@r>^Dt y HK>2VH =+P';AF
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(282) UUKMGxG; >2@,WA;PP,DENG;*dHF a H;$d2MG=+H*d"Wg `*z -NHUWa]H tH; LGH =_ _ B]
(283) W ]HKZGH =g2 H d?>^MF@,H*d"@1g7;A*D UWGP1P'HUK>[=H>2= W. . . 8.
(284) HAL author manuscript inserm-00108382, version 1. d xGH%Uk> @ZH0F;k> ;6WAExG; =+HA$> ;P
(285) @,AjUW
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(402) g^MAUk> @,WA@1A q A> H = A;K>2@,WAj;P JKW*MG= Aj;TPGWg z xG@,FHa@RW
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(404) ?G 2G* n ; ]PRW= l z N=+;V@a ` l ;kZH%D ` a@¢>2V] F*ZGH =(dHCdW
(405) U@,WGHUWAWa]@'U6xGW d+@r>2@RWA];%U =+W/d(d[>2VjH P@,g HUWjMG=d+H6@,AGU =+H;d+H*d"UW= WA;=DOVGH; =2>F*@'d+H;$d+H6=+@^d L UkMGaEMP';k> @ZHTP,D7*g2@1AGF@,A/d"g^=+W
(406) a>2VH hs=+@r>2@^d+V tWa]HA dVH; =?> ; AjFEVH;Pr>2Vd2>^MFjDJKW*MG= A;PGW
(407) g z x@,FGHTa]@,WGP,WDt;TAjF f WGa aEMA@r>2DCB H%;TP¢> V G
(408) ,G r~
(409) } ~ 2 K h0PR;TAGH l*B]; =^> fon l ` a]@r> V] lGC@,P,P@^d f w0l*BtWP,H JKl*Bt ; C>2VjW= AH 0: Ed(d+WGU@,;k> @,WA]Wg U; =F@,W*ZG;*dUkM/P'; ="F@dH$;d+H6=+@^d Lg2;%Uk> W=d E@¢>2Vd+WGU@,W
(410) H%UWAjW*a@'U6xGW/d+@r> @RWA]F$MG=+@,A* U V@'P'FVjW
(411) WGF]; AF F$MG=+@,A* ;F$MPr>2VWGW
(412) FGThs= @¢> @d+V :<HF@'U;P
(413) JWjMG= Aj;P | , ~~* K G( K }j 2 p0MV l*Bt; =+F*DCwil n ; A*GHA*NH = f l*w6@RUTVG;=+F
(414) d[:<l*b;F d ]W=^>2VC: z J: W=^> ; P,@r>2D]@,A;%F$M/Pr>+d ; GHFEG|8EDjH; =d=+HP';k> HF>Wd W
(415) U@,W
(416) H%UWAjW
(417) a]@'U0UWAjF@¢> @'WA
(418) d"@,A]UV@1P'FVWGW
(419) F]; AjF];F$M/P¢>2VWWGF xGW/d> t; =NG@ =?>2V]UWVW=> d?>^MF$DThs=+@r>2@^d+VC:HF@'U;PGJKW*MG= A;PG* , / ~ ~* ~|(
(420) }/ 2 Bt; =?> f n ljBOWP,H JKl ` a]@r>2V] q Ag2PMHTAjUH0Wg dW
(421) U@,WGHUWAWa @'U0U@=UkMa3d?> ; AjUH*do@,A]H%; =+P1Dt;TAjF P';k> H =P,@g H0WAd?>2= WLGH5= @^d L ;a]WA*a HA]@,A]; ` UW$>>2@d+VtUWVjW=2>d^>^MF$D/ ` >2= WLGH G , G G~/ 2 :<;=8atWj> :<l ` V@xGP'H DE:<l*hs=?MGAAH = z l*B]H a]@,A
(422) t;%DOB3wiHTPR;k> @ZH0UWA>2= @N*M> @,WA]Wg7H;=8PD P@,g H ; AjF ;%F$M/Pr>"dW
(423) U@,WGHUWAWa]@U0g2;Uk>2W=(d >2W];F$MGPr> a]W=?NG@,F@r>?D @,AC>2VjHib V@¢> HTVj;PP q q d2>^MF$D/JKW*MG= Aj;TP Wg z xG@,FHa@,W
(424) PRWD];AjF f W
(425) a]aEMA@r>?D BtH;Pr> VOG *,G8 ~
(426) 2/ F;a3doJljbV@r> H :<l* H; =+UH : ` l$ ; = LGH = n n @,g H0UW*MG=(dHa]H%;jd2MG=+H$d"Wgd+WGU@,W
(427) H%UWAjWa]@'U xGW/d @r> @,WA];AFd+HP,g[=+HxGW=^> HFEVH;Pr>2Vt;k> ; GHC Tx= W/d xGHUk>2@ZH0UWVjW=^>"d^>^MF$D/JKW*MG= Aj;TPGWg z xG@, FHa]@,W
(428) P,WD ;TAjF f Wa]aEM/A@r>2D B H;Pr> VEG* ,
(429) } */}( *G/ 2G|* z Pd2> ;FEJ q f V@,PFVWGWGFE;F$ZGH=(d+@r> @,H*d";AFEVH;Pr> VEZG; =+@';k>2@,WA
(430) d ;TatW
(431) A* a @'FFP'H ; GHF]a HTA *;6=+Hk> =+W/d xGHU(>2@ZGH0P@,g H$U%WjMG=(dHCd?>^MF$D z MG= WxGH%; AEJKW*MG= Aj;TPGWg/[MNGP'@U BtH;Pr> VEG
(432) , ( KR +}G 11.
(433) HAL author manuscript inserm-00108382, version 1. 2G~* q FP,H = z n ljhiH A*D;a @,AG@ ` HP,g2?=+;K> HFEVH;Pr> V]; AjF a]W=?>2;P,@r>2D7* =+H ZG@'H Wg/> tH A$>2Dj8d+H ZGHA UWa]atMA@r>2D3d?>^MF*@'H$d$JWjMG= A;PGWg/BtH;Pr> V];AF ` W
(434) U @R;TPh HV; ZG@,W=+~ , }(Kk ~/ 2/} :<WP,P'H = n ljp =+@^d?> HA/d+HA] ` l*BOWP1P,AG; GHP*B ` HP,g =+;k> HFEVGH;Pr>2V];d";6x=+HF@,Uk> W=7Wg7UW= WA;=D VH%; =?> F*@^d+H;*d+H0@,A f WxGHAV; HAl H Aa ; = L $JWjMG= Aj;PGWg z x@,F
(435) Ha]@,W
(436) PRWD ;AF f W
(437) a]aEM/A@r>2D BtH;Pr>2V | ,
(438) ?k ?/}j 2G* :<@,@PMA*xG;P,W ` l MW*= @ q l
(439) \ +; l*;d+; AGHAC:ljmO= xWAHAtB ` H P,g 2=+;k> HFEVH%;TP¢>2Vd?> ;k>^M d ;$d"; VH%;TP¢> V]a H;$d2MG=+H*VH6x=+H%F@'Uk>2@ZH ZG;PMH0W
(440) gd+HP,g ?=+H xGW=>HFEVH;Pr> Vd2> ;k>^M dWA0>2VH M d+H0Wg xV*D/d+@' U@,;Ad+H=ZG@'UH*d";AF]WA]a]W=?> ; P,@r>2D]@,AE>2VH tW= L@1AG ; GH6xGWx*MGP,;k> @,WA/JKW*MG= A;PGWg f P@,AG@U%;TP z xG@, FHa]@,W
(441) P,WD ~ ,
(442) 8kR ~8/}G * :<;=8atWj> : 0l*hsW*NG; LE: q A> Hk= Aj;k>2@,WAG;PGUW
(443) aExG; =;k> W=d7Wg xGW*ZGH =?>^Dt;AF]VH;Pr> V]@1A z MG=+WxGH hs=+@r> @'d+VC:<HF@'U;TPJWjMG= A;P
(444) G , KG K/}G K f ; ZGHP';; =(d z J8:<l*p0MA/d?> z lG HkMG=>+d7J(J+:<l*B]HP,a H =?>/mtl n MGAF*NGH = \ lj: @'HTP'U L cHk> ; P^ :<W=?NG@,F@r>2D]F@g2g H =+HAGUH$dNDtW
(445) UUKMGxG;k> @RWAj;TPGUP';*d(d";a]WGA a HA]@,Ad+H ZGHA z MG=+WxGH; A]U%WjMGA>2= @,H$dk ; A];xx
(446) P'@U%;k> @RWA]Wg/>2VH z = @L d+WA WP,F$>2VW= xGHCd+WGU @,;PUP;*ddd+UVHa H* q A$> H= A;k> @,WA;PGJKW*MG= A;PGW
(447) g z x@,F
(448) Ha]@,W
(449) PRWD
(450) } ,*G~?k G? G ";%DjP,W=[w0l f W*A t; D n l f ;P,FH = ]WGW
(451) F n l n H$dd+Wg f :<H >2VjW
(452) FWP,WD/:<;=8atWj>/:ljhi; AL/dJKl h0P¢M/AjFHTP'Pwil n H$dKd+Wg f l y ; u =+WW]JKlHF*@¢> W=(d0G n W*AFWAl q Y ` B]H%;TP¢>2!V ]H%;TP¢>2V];AF P,@'g H d?>^DjP'Hjd Wg/>2VH0WP,FH =xGWx*MGP,;k> @,WA]@1A z A*GP';TAjF/*VH6G* z A*GP,@d+V n WA
(453) @r>^MF@,AG;P ` >^MF$DtWg 0GH@,A hiWAjHAg2;TA> ` l f MG=H> H P,P@'UH =[:l
(454) WPRFjNH = E:<l*pO;A@ H 3d LG@ y l n HUP'H =++U l
(455) \ u *MP,H = cHk> ;P^ n ;0UWVjW=^> H0 ; u H PGFH$d Gl1CZW
(456) P,WA$> ;@=+H$d* AA H K 0G* ; = @dl q y `*z w :{mEA@r> }}G Bt;T@^d LGHTAj H y H Jo l*Y =+@,U L]JowO H$d L*>2WxUWaExG;A@,W
(457) AC>WO>2VjH0CH= a];A ` W
(458) U@,WG z U WAWa]@'U ; AHP ` >^MF$D/ G ThiH = P1@,Ajl ` \ z :<;%U LGHA*NG;UVEJ+l O; AFGHa VGH%HTA B]l ` >2= WAL/d[p * x=+W
(459) d xGHUk> @ZGH0UWVW=>"d^>^MF$D]@,A*ZGH*d2> @G;K> @,A* >2VH0 H xGP;Aj;k> @RWA]Wgd+WGU@,W
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