Oxidative and energetic stresses mediate beta-cell dysfunction induced by PGC-1α

L’implication de PGC-1 et de ses différents variants dans le développement musculaire chez l’homme et chez la souris ont orienté mes travaux de thèse sur l’étude

O 2 flux control ratio (ratio of oxygen consumption dedicated to ATP synthesis and proton leak over routine respiration) reaches 60 % for mitochondrial ATP synthesis and 40 % for

Ecris 4 mots contenant [ɔ̃] en remettant les lettres dans l’ordre... Complète les phrases avec des mots

1) To set up a reproducible in vitro model of lipotoxicity in pancreatic beta cells, by comparing the effects of different FFA preparations on beta cell viability and

In this study, we found that BHV-1 infection of MDBK cells dramatically increased the production of cellular ROS, which is essen- tial for virus replication (Figures 1 and 2)..

Dopa- minergic specific expression of srl-EY causes a more severe decrease, however, srl-RNAi expressing flies live longer and climb slightly worse than UAS-lacZ controls indicating

Irrespective of the glutamate levels measured in glucose- stimulated cells, the principal observation is that glutamate directly stimulates insulin exocytosis in permeabilised cells

Cells overexpressing GAD follow- ing AdCA-GAD65 infection and stimulation with high glucose could therefore theoretically release significant amounts of GABA with a possible