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Fragrance allergy: the limits of testing; the interaction with atopy and future
legislative direction
1. Summary – Résumé – Samenvatting ………..………..1
2. Overview and Glossary………..…………..4
3. Introduction……….…….8
4. Epidemiology in non-dermatology patients……….….18
a. White JM, Gilmour NJ, Jeffries D, Duangdeeden I, Kullavanijaya P, Basketter DA, McFadden JP. A general population from Thailand: incidence of common allergens with emphasis on para-phenylenediamine. Clin. Exp. Allergy 2007; 37: 1848-53.
5. Could fragrance mix I cause active sensitization?...27
a. White JM, McFadden JP, White IR. A review of 241 subjects who were patch tested twice: could fragrance mix I cause active sensitization? Br J Dermatol 2008; 158: 518-21.
6. The interaction of atopy with fragrance allergy……….34
a. White JM, White IR, Kimber I, Basketter DA, Buckley DA, McFadden JP. Atopic dermatitis and allergic reactions to individual fragrance chemicals. Allergy 2009; 64: 312-6.
b. McFadden JP, White JM, Basketter DA, Kimber I. Reduced allergy rates in atopic eczema to contact allergens used in both skin products and foods: atopy and the ‘hapten-atopy hypothesis’. Contact Dermatitis 2008; 58: 156-8.
c. McFadden JP, White JM. Reduced frequency of atopic dermatitis in quinolone-allergic patients: the ‘hapten-atopy hypothesis’. Contact Dermatitis 2008; 58: 291-5.
d. White JM, McFadden JP. Contact allergens in food ingredients and additives: atopy and the hapten-atopy hypothesis. Contact Dermatitis 2008; 58: 245-6.
e. White JM, McFadden JP. Exposure to haptens/contact allergens in baby cosmetic products. Contact Dermatitis 2008; 59: 176-7.
f. McFadden JP, White JM, Basketter DA, Kimber I. Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis. Trends Immunol 2009; 30: 67-74. g. McFadden JP, Dearman RJ, White JM, Basketter DA, Kimber I. The Hapten-Atopy
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7. Oral tolerance to fragrance chemicals?...72
a. White JM, Goon AT, Jowsey IR, Basketter DA, Mak RK, Kimber I, McFadden JP. Oral tolerance to contact allergens: a common occurrence? A review. Contact
Dermatitis 2007; 56: 247-54.
8. Fragrance update on individual sensitization……….……….81
a. Mann J, McFadden JP, White JM, White IR, Banerjee P. Baseline series markers failto predict contact allergy. Contact Dermatitis 2014; 70: 276-81.
b. Ung CY, White JM, White IR, Banerjee P, McFadden JP. Patch testing with the European baseline series fragrance markers: a 2016 update. Br J Dermatol 2018; 178: 776-80.
9. Legislation and increase in isoeugenol allergy despite legislation………93
a. White JM, White IR, Glendinning A, Fleming J, Jefferies D, Basketter DA, McFaddenJP. Frequency of allergic contact dermatitis to isoeugenol is increasing: a review of 3636 patients tested from 2001 to 2005. Br J Dermatol 2007; 157: 580-2.
b. Pink AE, White JM, White IR. A call for full ingredients labelling and uniform nomenclature on medicaments. Br J Dermatol 2009; 161: 470-92.