1
Figure 5. Section of the NOESY spectrum of 19-epi-DTX2 showing the correlation between
H18 and H23 (A) and of DTX2 showing the absence of a correlation (B). Geometrical optimizations of 3D chemicals structures for 19-epi-DTX2 (C) and DTX2 (D).
16 17 18 19 20 21 22 23 24 25 26 16 17 18 19 2021 22 23 24 25 26 H23 H18 H23 H18
A
B
C
D
2
Figure 6. Stability study results for CRM-OA showing stability when stored at recommended
conditions of -12○C and degradation at the stress condition of +37°C (A). Increase in an isomeric degradation product (19-epi-DTX2) detected at temperatures >-12°C in CRM-DTX2 (B).
Time (days) 0 150 300 450 600 750 C on c . N o rm al iz e d t o -80 °C m e a n 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 Average -80°C ± 2 × SD -80°C -12°C +4°C +18°C +37°C Time (days) 0 150 300 450 600 750 C on c . N o rm al iz e d t o -80 °C m e a n 0 2 4 6 8 10 12 14
