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Supplemental Table S4. Features of the 7 Day Model (Males vs. Females).Featurep-valueCoefficient

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Supplemental Table S4. Features of the 7 Day Model (Males vs. Females).

Feature p-value Coefficient

CD4Tmem_p-p38 0.0001554 -0.002063077 pDCs_pCREB 0.0001554 -0.002361383 CD4Tmem_pERK 0.0001554 -0.108933164 CD19+IgM+B_CD62L 0.000621601 -0.024117698 cMCs 0.000621601 -0.038030371 CD19-IgM-B 0.001087801 -0.002900917 pDCs_p-p38 0.001087801 -0.018820384 CD4Tmem_pNFkB 0.001087801 -0.030154287 CD19+IgM-B_CD62L 0.001087801 -0.077235968 CD4Tmem_pMAPKAPK2 0.001087801 -0.113517802 pDCs_pMAPKAPK2 0.001864802 -0.020908603 mDCs_p-p38 0.002952603 -0.006323731 CD19-IgM-B_pCREB 0.006993007 -0.000206239 CD19+IgM+B 0.01041181 0.002095558 CD4Tmem_CD62L 0.014763015 0.003257027 CD19-IgM-B_p-p38 0.028127428 -0.000413348 Neutrophils_pSTAT3 0.037917638 -0.01743663 Neutrophils_pNFkB 0.04988345 0.001006339 intMCs_pCREB 0.04988345 -0.003460887 CD19-IgM-B_pMAPKAPK2 0.04988345 -0.021692609 intMCs_pERK 0.064957265 -0.000408527 mDCs_pSTAT3 0.064957265 -0.001036695 NKT_pSTAT3 0.064957265 -0.004167777 CD49+NK11-NK_CD62L 0.082983683 -0.025183045 Neutrophils_IkB 0.104895105 1.17E-05 CD19+IgM-B 0.13038073 -0.014593982 pDCs_pNFkB 0.160528361 -0.000113069 CD49+NK11+NK_pSTAT3 0.194871795 -0.001708863 mDCs_pStat6 0.234498834 0.029862721

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mDCs_pERK 0.234498834 -0.000662805 Neutrophils_pStat6 0.234498834 -0.00189813 Tregs_pCREB 0.278632479 0.000895249 mDCs_pSTAT1 0.278632479 0.000250629 CD19-IgM-B_pERK 0.278632479 -0.000263927 intMCs_CD62L 0.328205128 0.02637797 pDCs_pStat6 0.328205128 -0.022774089 CD8T_pSTAT1 0.382284382 0.007084423 CD8Tnaive_pSTAT1 0.382284382 0.006378636 NKT_pS6 0.382284382 0.000920123 CD4Tnaive_pMAPKAPK2 0.382284382 -7.33E-05 CD8T_pSTAT5 0.441802642 0.00376361 CD8Tnaive_pSTAT5 0.441802642 0.001331191 ncMCs_CD62L 0.441802642 0.000903966 mDCs 0.560041003 0.050842007 pDCs_IkB 0.573737374 0.00131485 NKT_pStat6 0.573737374 -0.001273032 CD49+NK11+NK_pSTAT5 0.645376845 -0.001559655 NKT_CD62L 0.720901321 -0.001337705 CD8T_pNFkB 0.878477078 0.000590954 CD49+NK11-NK_pCREB 0.959129759 0.000847755 CD49+NK11+NK_IkB 0.959129759 0.000340646 CD49+NK11+NK_pStat6 0.959129759 -0.00504225

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