• Aucun résultat trouvé

Low stress weekends promote adaptation to stressful weeks: The design principles of the biological response to stress


Academic year: 2021

Partager "Low stress weekends promote adaptation to stressful weeks: The design principles of the biological response to stress"

En savoir plus ( Page)

Texte intégral


Low stress weekends cannot promote adaptation to stressful weeks: The design principles of the biological response to stress.

Nilgun Yilmaz, Amsterdam, The Netherlands; Alexey Kolodkin, Seattle, USA/

Luxembourg, EU; Nick Plant, Surrey, UK; Hans Westerhoff, Manchester, UK

Robustness is a fundamental and essential property of evolvable biological systems. It provides system to conserve its functionalities against internal/external perturbations and uncertainties. Product inhibition, feed-forward and feed-back inhibition and stimulation, and regulatory loops within signal transduction networks are a few of the approaches generated by biological systems to maintain both their robustness and adaptability. In this study, we are able to show the interaction of the stress hormone cortisol with its two nuclear receptors, the high affinity glucocorticoid receptor (GR) and the low affinity pregnane X-receptor (PXR) by using a mathematical model based on realistic kinetic parameters. We checked the importance of regulatory loops, within this network, in terms of pharmacodynamic and pharmacokinetic responses. Then, we demonstrate the alterations in the system response with respect to variable cortisol perturbations, such as initial single peak in cortisol, and repeated stimuli of cortisol with differing frequencies and time frames. As a conclusion, we reveal that the network is robust towards low frequency perturbations, shows adaptation at moderate stress frequencies, but transitions to an altered steady state at high frequency stimulation, which we believe is a predisposing factor towards stress-induced pathologies.


Documents relatifs

The purpose of the present study was to determine the in-vitro activity of fleroxacin in comparison with ciprofloxacin and norfloxacin against selected strains of susceptible and

Also, the representation of the density of detected AE signals on the gauge length of the specimen versus the time of test (Figure 7) allowed locating the

There is a stress relaxation with each pore fluid (Figure 3), the attenuation peaks are all narrow and have approximately the same center frequency, but the magnitudes.. of

mutans, l’expression du gène dnaK et la quantité de protéine DnaK sont plus élevées dans les cellules adaptées à l’acide que dans les cellules non adaptées, et augmentent

Strain differences in hypothalamic-pituitary-adrenal (HPA) axis cross- sensitization were determined by plasma corticosterone (CORT) levels and hippocampal gene expression

Participants receiving positive feedback (i.e., High Expectancy group) showed a more positive anticipatory cognitive stress appraisal (i.e., they anticipated the

De plus leur composition intéressante en protéines et en acides aminés indispensables, les légumineuses sont très riches en fibres (entre 12 et 31 % contre 2% seulement pour les

probantes L’activité physique ou les exercices de respiration pratiqués pendant la journée scolaire aident les élèves à mieux se concentrer et à rester attentifs tout au long de

Hannart (2011), Inferring change points and nonlinear trends in multivariate time series: Application to West African monsoon onset timings estimation,

The vibroacoustic response of the fluid filled cylindrical shell coupled to two ring stiffeners and excited by deterministic (force/monopole) or stochastic (TBL)

ﻲﻣﯾھﺎﻔﻣ لﺧدﻣ : ىرﺧأ ﻰﻟإ ﺔﻓﺎﻘﺛ نﻣ تﻔﻠﺗﺧا مﯾھﺎﻔﻣ نﯾﺑ نورﻗ ىدﻣ ﻰﻠﻋ ﺔﻏﻼﺑﻟا موﮭﻔﻣ ﺢﺟرﺄﺗ ، بﺎطﺧﻟاو مﻼﻛﻟا فﺻو ﻲﻓ ضﯾرﻋ مﮭﺳﺑ مﮭﻟ اوﺑرﺿ نّﻣﻣ ﺔﱠﯾﺑرﻌﻟا ءﺎﻣﻠﻋ

Because the expansion of brickwork was much greater in the vertical direction than horizontally, however, and because the expansion was inhibited greatly by a

Through chapter 2, some possible explanation was given for the temperature profile around gold particles in water under alternating magnetic field.. But there is a

In this regard, systemic LPS insult causes a profound transcriptional activation of the gene encoding IL-6 in the sensorial circumventricular organs (CVO) and the choroid plexus,

In the endocrine stress response, ILPs have been shown to play a crucial role together with biogenic amines (5-HT, OA, and DA), 20-hydroxyecdysone and juvenile hormone (JH) – hormone

In the absence of telomerase, defects in telomere replication can lead to premature senescence, caused by the occurrence of at least one critically short telomere (Abdallah et

Egg-to-adult viability, developmental time and adult body size were assayed after 29 generations of selection, pupal lipid content after 32 generations, larval tolerance to heat

Antoine Stier, Quentin Schull, Pierre Bize, Emilie Lefol, Mark Haussmann, et al.. Oxidative stress and mitochondrial responses to stress exposure suggest that king penguins

Louis XIV renonce à la scène s’inscrit d’ailleurs dans la période où s’imposent les danseurs professionnels et où la vieille tradition du ballet de cour disparaît au profit

Cambridge-London-New York-New Rochelle-Melbourne- Sydney, Cambridge University Press, 1984, xv+189p., bibl., index (“Cambridge Studies in Cultural Systems

The degree of functional enrichment for a given cluster and category was quantitatively assessed (p value) by hypergeometric distribution and a multiple test correction was

Adaptative responses of Bacillus cereus ATCC14579 cells upon exposure to acid conditions involve ATPase activity to maintain their internal pH. Amino acids improve acid tolerance