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Ecdysone Biosynthetic Pathway

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OH OH O H H OH OH O H H 2-Deoxyecdysone (2dE) OH

nvd log2FC -5.69, pval *** phm log2FC -5.69, pval ***

dib log2FC -2.26, pval *

sad log2FC -5.96, pval *** shd ns

spo log2FC -5.99, pval *** sro log2FC -2.5, pval ***

7-DehydroxyCholesterol (7dC) Cholesterol (C) OH OH OH H H O OH OH

Ecdysone Biosynthetic Pathway

Ketodiol (2,22,25dE) Ketotriol (2,22dE)

H H O OH OH OH Ecdysone (E) OH OH H HO OH OH OH 20-Hydroxyecdysone (20HE) OH OH H H O OH OH OH OH

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